Occupational asthma and allergy in snow crab processing in Newfoundland and Labrador

Gautrin, Denyse; Cartier, André; Howse, Dana; Horth-Susin, Lise; Jong, Michael; Swanson, Mark C.; Lehrer, Samuel B.; Fox, George A; Neis, Barbara

doi:10.1136/oem.2008.039578

Cited by 67 publications

(66 citation statements)

References 26 publications

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“…We did not have adequate research funds to measure specific IgE antibodies in this study. Previous studies have found that immunological sensitization to snow crab allergens was significantly associated with asthma among snow crab processing workers (8,10,34). Although this study was unable to estimate immunological sensitization to snow crab allergens, it can be said that this type of sensitization may be significantly associated with asthma among Japanese snow crab processing workers.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of asthma and wheezes among snow crab workers in western Japan: a cross-sectional study

et al. 2016

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: Objectives : Few reports are available concerning the prevalence of asthma among snow crab workers in Japan. The object of this study was to estimate the prevalence of asthma and wheezes among Japanese snow crab workers and their associations with exhaled nitric oxide (FeNO) and YKL-40. Methods : Forty-nine snow crab workers enrolled in this study, which was cross -sectional by design and was conducted using a translated version of the European Community Respiratory Health Survey questionnaire. The levels of FeNO and serum YKL-40 were measured between September and October 2014. Results : The prevalences of current asthma and wheezes were 10.2% % (95% % CI, 3.4 to 22.2) and 12.2% % (95% % CI, 4.6 to 24.8), respectively. There was no association between these prevalences and the duration of snow crab employment. Six subjects' FeNO levels exceeded 50 ppb, and nine subjects' levels exceeded 25 ppb. Twelve subjects' (25.5% %) serum YKL-40 levels exceeded 77.2 ng/mL, which was 2 standard deviations above the mean for healthy subjects. However, there were no significant relationships among the prevalences for asthma and wheezes, FeNO, and serum YKL-40. Conclusions : This study provides information concerning the prevalences of asthma and wheezes among Japanese snow crab processing workers.

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Section: Discussionmentioning

confidence: 99%

Prevalence of asthma and wheezes among snow crab workers in western Japan: a cross-sectional study

et al. 2016

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“…Several studies report a high incident of occupational asthma in workers processing snow crab (Chionoecetes opilio) and king crab (Paralithodes camtschaticus), but other symptoms as rhinitis, conjunctivitis, and skin rash are also registered (Orford and Wilson, 1985;Cartier et al, 1986;Ortega et al, 2001;Howse et al, 2006;Gautrin et al, 2009). Although a majority of the literature point to an IgE-mediated mechanism for the development of respiratory disease among crab processing workers, there are reports that fail to show a clear correlation between crab specific IgE and new incidents of asthma-like and bronchitis cases (Ortega et al, 2001).…”

Section: Introductionmentioning

confidence: 99%

Purified sardine and king crab trypsin display individual differences in PAR-2-, NF-κB-, and IL-8 signaling

Larsen

Seternes

Bang

2011

Toxicological & Environmental Chemistry

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Respiratory symptoms are present in workers processing a great variety of seafood, including the salmon, sardine, and king crab industry. We have previously shown that salmon trypsin is able to generate DNA-binding of NF-κB and induce secretion of IL-8 from airway epithelial cells by activating PAR-2. In this study we explore if purified trypsins from king crab (Paralithodes camtschaticus) and sardine (Sardinops melanostictus) is able to induce similar effects in cell stimulation assays. Different types of seafood seem to display dissimilar irritant/allergic potencies in human airways and molecular modelling has identified divergent positions in the king crab trypsin compared to salmon trypsin that might influence upon the binding to the N-terminal end of PAR-2, which is a prerequisite for proteolytic activation of the receptor. This knowledge inspired us to investigate if we could detect differences in intracellular signalling pathways coupled to IL-8 in human airway epithelial cells (A549) following stimulation with purified king crab and sardine trypsin. Both sardine and king crab trypsin induce secretion of IL-8 from human airway epithelial cells in a concentration-dependent manner and generate DNA-binding of activated NF-κB. By the use of siRNA we can conclude that these effects are both mediated, at lest partly, through the activation of PAR-2. The king crab and sardine trypsin displays individual differences in transformation of the NF-κB signal, as high enzyme concentrations of king crab trypsin yields high levels of NF-κB that does not translate into increased secretion of IL-8 in the cell stimulation assays. The contribution of MEK/ERK, p38 and NF-κB to the secretion of IL-8 following stimulation with purified sardine and king crab trypsins were explored by the use of specificinhibitors. The results demonstrate that MEK/ERK and NF-κB are both required for purified sardine and king crab trypsin-induced secretion of IL-8 but via separate pathways. P38 was also found to contribute to the secretion of IL-8 by seemingly NF-kB-dependent processes.The data presented indicate that small structural variations in agonists may lead to differences in receptor activation and subsequent intracellular signalling.

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“…Adverse health effects from bioaerosol exposure (Eduard et al 2012;Shiryaeva et al 2013;Watanabe et al 2016;Gautrin et al 2010;Jeebhay et al 2008) such as immunological sensitisation, respiratory symptoms, bronchial hyper-responsiveness and occupational asthma have been found in exposed seafood workers. Sensitisation is documented in workers processing fish, mussels, prawns and crabs.…”

Section: Introductionmentioning

confidence: 99%

“…Adverse health effects or a dose-response relationship between levels of different components of bioaerosols and respiratory symptoms, allergy, and asthma are found in seafood workers, including snow crab workers (Lopata and Jeebhay 2013;Jeebhay 2011;Jeebhay et al 2001;Gautrin et al 2010). …”

Section: Introductionmentioning

confidence: 99%

Occupational Exposure to Bioaerosols in Norwegian Crab Processing Plants

Thomassen¹,

Kamath²,

Lopata³

et al. 2016

ANNHYG

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Occupational asthma and allergy in snow crab processing in Newfoundland and Labrador

Abstract: The prevalences of OA and OAl are high in snow crab-processing workers of Canada's East Coast. Cumulative exposure to snow crab allergens was related to the prevalences of OA and OAl in a dose-response manner taking into account atopy, gender and smoking.

Cited by 67 publications

References 26 publications

Prevalence of asthma and wheezes among snow crab workers in western Japan: a cross-sectional study

Prevalence of asthma and wheezes among snow crab workers in western Japan: a cross-sectional study

Purified sardine and king crab trypsin display individual differences in PAR-2-, NF-κB-, and IL-8 signaling

Occupational Exposure to Bioaerosols in Norwegian Crab Processing Plants

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