Occupational asthma and rhinitis caused by multiple herbal agents in a pharmacist

A case of occupational asthma and rhinitis caused by Sanyak and Korean ginseng dusts

“…There have been few reports of occupational asthma induced by herb materials (1)(2)(3)(4)(5)(6). Until now there has been no account of occupational asthma caused by Korean ginseng.…”

Anti-inflammatory activity of 6-hydroxy-2,7-dimethoxy-1,4-henanthraquinone from tuberous roots of Yam (Dioscorea batatas) through inhibition of prostaglandin D2 and leukotriene C4 production in mouse bone marrow-derived mast cells

“…5, PAQ caused the dose-dependent inhibition of β-Hex release with an IC 50 of 2.7 µM. Other groups have previously reported the harmful effects of Yam, which may act as an inhalant allergen, inducing allergies and bronchial asthma in a typical IgE-mediated response (Park et al, 1994;Kim et al, 2001;Lee et al, 2001Lee et al, , 2006Hur et al, 2008). Quite recently, we reported the anti-inflammatory activity of the bark of Yam (D. batatas) associated with the inhibition of COX-2 and iNOS expression in LPS-induced murine RAW264.7 macrophages via the inhibition of NF-κB activation and ERK phosphorylation (Jin et al, 2010).…”

Occupational Asthma Related to Mouse Allergen Exposure and Rhinoconjunctivitis due to Collagenase Inhalation in a Laboratory Technician

“…The possibility of presenting double or multiple sensitivity against unrelated antigens is rarely cited. Santaolalla et al [20] described a case of double sensitization to fungal α-amylase and egg lysozyme in a baker, and Lee et al [21] reported a case of OA and rhinitis caused by multiple herbal agents in a pharmacist. The double sensitization in our patient was probably not due to an atopic state, because the levels of total IgE were low and skin prick tests to common pneumoallergens were negative.…”