Occupational Asthma: Classification and Clinical Aspects

Davies, Robert; Blainey, A. D.

doi:10.1055/s-2007-1011457

Cited by 16 publications

(6 citation statements)

References 42 publications

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“…More than 200 substances can cause occupational asthma 8 ) , but metal asthma is a rare phenomenon. Metals that are known to cause asthma are nickel 9 – 12 ) , platinum 13 ) , chromium 11 , 14 ) , cobalt 15 , 16 ) , vanadium 17 ) and zinc 8 ) . In 1985, Simonsson et al 5 ) .…”

Section: Discussionmentioning

confidence: 99%

Increased Neutrophil Chemotactic Activity is Noted in Alminum-induced Occupational Asthma

Park

1996

Korean J Intern Med

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A worker with occupational exposure to aluminum powder developed asthmatic symptoms three years and six months after starting work. Skin tests (prick and intradermal) to aluminum chloride (AlCl3) were negative. Inhalation challenge test with 10 mg of aluminum powder and 10 mg/ml of AlCl3 solution induced an early asthmatic response. Sodium cromoglycate pre-treatment reduced AlCl3-induced bronchoconstriction. Neutrophil chemotactic activity was markedly increased one and seven hours after the challenge procedure, which was lessened with sodium cromoglycate pre-treatment. Aluminum can induce occupational asthma in exposed worker, which may be mediated by a non-immunologic mechanism and the possible role of neutrophils was suggested.

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Section: Discussionmentioning

confidence: 99%

Increased Neutrophil Chemotactic Activity is Noted in Alminum-induced Occupational Asthma

Park

1996

Korean J Intern Med

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“…More than 200 substances are known to cause occupational asthma [27], but metal asthma is a rare phenomenon. Metals that can cause it are platinum (Pt) [25], r. Shirakawa et al chromium (Cr) [24], nickel (Ni) [20][21][22][23], vanadium (V) [28], zinc (Zn) [29], cobalt (Co) [13] and aluminium (Al) [30].…”

Section: Discussionmentioning

confidence: 99%

The existence of specific antibodies to cobalt in hard metal asthma

Shirakawa

Kusaka

Fujimura

et al. 1988

Clin Experimental Allergy

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Summary Twelve workers with hard metal asthma diagnosed on the basis of peak flow diaries and positive bronchial reactions to cobalt chloride (CoCl2) were studied for sensitization by detection of specific antibodies to radioactive cobalt (57Co), cobalt‐conjugated human serum albumin (Co‐HSA) and cobalt‐conjugated exchange resin (Co‐resin). Their IgE titres ranged from 73 to 1500 IU/ml and eight were atopic individuals. Sixty serum samples from asthmatic patients with IgE titres of 14–4300 IU/ml were studied as controls in all tests. Eleven of twelve subject sera that selectively bound to 57Co after incubation with saturated ammonium sulphate (>232 c.p.m., P<0.01) were divided into three groups: (1) six sera showing evidence of specific IgE antibodies to Co‐HSA (>673 c.p.m., P<0.01) without those to Co‐resin; (2) one serum giving a positive radio‐allergosorbent test (RAST) only to Co‐resin (>417 c.p.m., P<0.01), and (3) four sera that were negative for two antigenic agents (Co‐HSA, Co‐resin). These results suggest that the subjects had occupational asthma due to hard metal exposure from cobalt sensitivity. An immuno‐allergic mechanism mediated by specific IgE antibodies to cobalt was confirmed to be responsible for the development of hard metal asthma, with the possibility of some role of the reaction without reagins.

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“…Agents capable of inducing occupational asthma can be vapors, gases, aerosols, or particulates and can range from very low molecular weight inorganic chemicals to complex organic macromolecules. [11][12][13][14] These agents include a wide range of animal-and plant-derived proteins, insect and plant dusts, organic and inorganic chemicals, pharmaceutical agents, and bacterial enzymes. Tables I through III list many natural organic environmental agents, organic chemicals, and inorganic chemicals that have been reported to induce occupational asthma plus the likely mechanism of disease production.…”

Section: Nature and Properties Of The Etiologic Agentsmentioning

confidence: 99%

“…These mechanisms may be important in bronchospasm induced by agents such as ozone, nitrogen dioxide, and sulfur dioxide at toxic concentrations. 2,12,17 Upper respiratory tract viral infections may also alter the integrity of tight junctions, allowing ingress of offending agents and facilitation of antigen absorption with enhanced potential for sensitization.…”

Section: Host and Environmental Risk Factorsmentioning

confidence: 99%

“…More effective are positive-pressure air hoods that prevent inhalation of contaminated air from the factory floor and a helmet type of positive-pressure respirator that protects against dusts. 12 Preemployment, regular immunologic screening, or both, may be used to identify workers deemed to be at high risk, such as atopic persons. If positive, these individuals should be advised against working in certain areas or industries in which atopy is known to predispose to occupational asthma, or should be monitored more frequently.…”

Section: Prevention and Therapymentioning

confidence: 99%

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