Occupational contact dermatitis caused by polyurethane foam: 6 cases

Allergic contact dermatitis caused by a polyurethane catheter

“…In 1976, Rothe observed that MDA can be formed by hydrolysis of 4,4 0 -diphenylmethane diisocyanate, and considered positive patch test reactions to MDA to constitute an important marker for isocyanate sensitivity. 1,2 This conclusion was confirmed by Goosens et al, who diagnosed 9 of 22 patients with occupation-related allergic contact dermatitis caused by isocyanates and/or polyurethanes who reacted only to MDA. 1 More recently, in a workshop handling polyurethane foams, 6 of 8 workers showed positive patch test reactions to MDA.…”

“…101‐77‐9) is an aromatic diamine that is used in the production of plastics, polyurethanes, rubber, epoxy resins, insecticides, and germicides. In 1976, Rothe observed that MDA can be formed by hydrolysis of 4,4′‐diphenylmethane diisocyanate, and considered positive patch test reactions to MDA to constitute an important marker for isocyanate sensitivity . This conclusion was confirmed by Goosens et al, who diagnosed 9 of 22 patients with occupation‐related allergic contact dermatitis caused by isocyanates and/or polyurethanes who reacted only to MDA .…”

“…This conclusion was confirmed by Goosens et al, who diagnosed 9 of 22 patients with occupation‐related allergic contact dermatitis caused by isocyanates and/or polyurethanes who reacted only to MDA . More recently, in a workshop handling polyurethane foams, 6 of 8 workers showed positive patch test reactions to MDA . To our knowledge, only 2 cases of contact dermatitis caused by a similar polyurethane central catheter have been published so far, and the causative allergens were not identified .…”

“…1 More recently, in a workshop handling polyurethane foams, 6 of 8 workers showed positive patch test reactions to MDA. 2 To our knowledge, only 2 cases of contact dermatitis caused by a similar polyurethane central catheter have been published so far, and the causative allergens were not identified. 3,4 Even though MDA was not listed in the composition of the PICC, clinical relevance was confirmed by positive reactions to the catheter and by subsequent clearance of the dermatitis through avoidance of exposure.…”

Contact Allergy—Emerging Allergens and Public Health Impact

“…Accidental spills may expose a worker to high concentrations of reactive monomers, which may lead to immediate sensitisation by such a single exposure to diisocyanates [171]. It has repeatedly been noted that, while diisocyanates are too unstable to be patch tested, the corresponding amines are a valuable screening tool, for instance, diaminodiphenyl methane, as in a recent case series with occupational ACD related to polyurethane foam from France [172]. p-tert-Butylphenol formaldehyde resin exists in a number of varieties; the resin included in the (European) baseline series is one of these and is of importance.…”