Occupational exposure to anticancer drugs — Potential and real hazards

Sorsa, Marja; Hemminki, Kari; Vainio, Harri

doi:10.1016/0165-1110(85)90024-7

Cited by 135 publications

(59 citation statements)

References 43 publications

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“…The increased frequency of sister chromatid exchanges and urinary mutagenicity indicated that the nurses handling cytostatic drugs had an increased exposure to potentially genotoxic substances. The health impact of this exposure is unknown (20), but some studies indicate that nurses exposed to cytostatic drugs have an excess frequency of fetal loss and of malformations in their offspring (21,22). Although the matching was good in terms of smoking habits and age between the nurses handling cytostatic drugs and the referents, we cannot entirely exclude the possibility that the differences in sister chromatid exchanges and urinary mutagenicity were attributable to factors other than exposure to cytostatic drugs.…”

Section: Discussionmentioning

confidence: 78%

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Comparison of methods for the biomonitoring of nurses handling antitumor drugs.

Thiringer¹,

Granung²,

Holmén³

et al. 1991

Scand J Work Environ Health

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Section: Discussionmentioning

confidence: 78%

“…The possibility of using urinary mutagenicity or cytogenetic methods for the biomonitoring of occupational exposure to cytostatic drugs has previously been discussed by Sorsa et al (20). However, they did not compare different tests or discuss the optimal design of a study.…”

Section: Discussionmentioning

confidence: 99%

Comparison of methods for the biomonitoring of nurses handling antitumor drugs.

Thiringer¹,

Granung²,

Holmén³

et al. 1991

Scand J Work Environ Health

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“…The conclusions of these studies were often contradictory, probably because of uncertainties concerning exposure level 20) or because effective protective measures were differently adopted 21) . In a follow-up study of genotoxic hazards in pharmacists and nurses handling ANPDs carried out four years after a first study, the frequency of MN in the exposed nurses and control subjects was not found to be statistically different after improving working conditions 11) .…”

mentioning

confidence: 99%

Biological Effect Monitoring in Peripheral Blood Lymphocytes from Subjects Occupationally Exposed to Antineoplastic Drugs: Assessment of Micronuclei Frequency

Villarini

Dominici

Fatigoni

et al. 2012

Journal of Occupational Health

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Biological Effect Monitoring in Peripheral Blood Lymphocytes from Subjects Occupationally Exposed to Antineoplastic Drugs: Assessment of Micronuclei Frequency: Milena VILLARINI, et al. Department of Medical‐Surgical Specialties and Public Health (Section of Public Health), University of Perugia, Italy— Objectives Antineoplastic drugs (ANPDs) are widely used in the treatment of cancer and some nonneoplastic diseases. However, most if not all of these chemical agents are generally nonselective and, along with tumor cells, normal cells may undergo cytotoxic/genotoxic damage. Italian pharmacists and nurses occupationally exposed to ANPDs during their normal work routines were monitored to evaluate biological effects (i.e., cytogenetic damage) eventually associated with exposure. The subjects were also monitored for primary, oxidative and excision repaired DNA damage as evaluated by comet assay (published data). In the present paper, we present the results obtained with the cytokinesis‐block micronucleus (CBMN) test. Methods The CBMN test in peripheral blood lymphocytes was applied because of its ability to detect both clastogenic and aneugenic effects, and because it has recently been reported that micronuclei (MNs) are predictive of cancer risk in human populations. In this study, the evaluation of MN frequency was carried out using the CBMN test in the absence or in the presence of the DNA repair inhibitor Ara‐C (cytosine arabinoside). Results No significant difference was observed for MN frequency comparing nurses handling ANPDs (exposed subjects) and controls; no correlations were found between job seniority, age, smoking habits and MN rates. Conclusions Concerning the aim of this study to evaluate the genotoxic risk arising from occupational exposure to ANPDs, statistically significant differences in MN rates in the subjects under study could not be determined.

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“…However, it is known that many anticancer drugs have been found to be mutagenic, teratogenic, and carcinogenic in in vitro and in vivo test systems, and secondary malignancies are known to be associated with several therapeutic treatments (11). Although CP has been shown to induce genotoxic effects in a number of assay systems, limited experimental data are available on their clastogenic potential in human lymphocytes in vitro.…”

Section: Introductionmentioning

confidence: 99%

Protective effect of thymoquinone against cyclophosphamide-induced genotoxic damage in human lymphocytes

Yüksel¹,

Taşdemir²,

Korkmaz³

2017

BLL

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OBJECTIVE: Protective effect of thymoquinone (TQ) against the cytotoxic and genotoxic effects of cyclophosphamide (CP) was assessed in human peripheral blood lymphocyte culture. METHODS: Mitotic indices were determined as endpoints of cytotoxicity, while sister chromatid exchanges (SCE) served as endpoints of genotoxicity. Firstly, the genotoxic effect of 0.16 μg/ml of CP was tested and CP was detected as genotoxic. In the second set, CP group was treated with 20 μM and 40 μM TQ. RESULTS: TQ reduced the SCE frequencies, suggesting its protective action on human lymphocytes in vitro against the CP induced genotoxic damage. CONCLUSIONS: Our results suggest that TQ produces a protective mechanism against CP-induced genetic damage, and suggest a role of DNA strand breaks in the genotoxicity (Tab. 1, Fig. 1, Ref. 19). Text in PDF www.elis.sk.

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Occupational exposure to anticancer drugs — Potential and real hazards

Cited by 135 publications

References 43 publications

Comparison of methods for the biomonitoring of nurses handling antitumor drugs.

Comparison of methods for the biomonitoring of nurses handling antitumor drugs.

Biological Effect Monitoring in Peripheral Blood Lymphocytes from Subjects Occupationally Exposed to Antineoplastic Drugs: Assessment of Micronuclei Frequency

Protective effect of thymoquinone against cyclophosphamide-induced genotoxic damage in human lymphocytes

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