Occupational exposure to chlorinated aliphatic hydrocarbons and risk of astrocytic brain cancer

Heineman, Ellen F.; Cocco, Pierluigi; Gómez, Manuel R.; Dosemeci, Mustafa; Stewart, Patricia A.; Hayes, Richard B.; Zahm, Shelia Hoar; Thomas, Terry L.; Blair, Aaron

doi:10.1002/ajim.4700260203

Cited by 76 publications

(65 citation statements)

References 32 publications

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“…These include studies of bladder cancer (12,(42)(43)(44)(45), brain cancer (46,47), buccal and oral cancers (48,49), childhood brain cancer (47), childhood leukemia (50) …”

Section: Case-control Studiesmentioning

confidence: 99%

Trichloroethylene and cancer: epidemiologic evidence.

Wartenberg

Reyner

Scott

2000

Environ Health Perspect

203

156

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Trichloroethylene is an organic chemical that has been used in dry cleaning, for metal degreasing, and as a solvent for oils and resins. It has been shown to cause liver and kidney cancer in experimental animals. This article reviews over 80 published papers and letters on the cancer epidemiology of people exposed to trichloroethylene. Evidence of excess cancer incidence among occupational cohorts with the most rigorous exposure assessment is found for kidney cancer (relative risk lRR] = 1.7, 95% confidence interval [Cl] 1.1-2.7), liver cancer (RR = 1.9, 95% Cl 1.0-3.4), and non-Hodgkin's lymphoma (RR = 1.5, 95% Cl 0.9-2.3) as well as for cervical cancer, Hodgkin's disease, and multiple myeloma. However, since few studies isolate trichloroethylene exposure, results are likely confounded by exposure to other solvents and other risk factors. Although we believe that solvent exposure causes cancer in humans and that trichloroethylene likely is one of the active agents, we recommend further study to better specify the specific agents that confer this risk and to estimate the magnitude of that risk.

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“…These include studies of bladder cancer (12,(42)(43)(44)(45), brain cancer (46,47), buccal and oral cancers (48,49), childhood brain cancer (47), childhood leukemia (50) …”

Section: Case-control Studiesmentioning

confidence: 99%

Trichloroethylene and cancer: epidemiologic evidence.

Wartenberg

Reyner

Scott

2000

Environ Health Perspect

203

156

View full text Add to dashboard Cite

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“…Several studies have observed an increased risk of brain tumors in association with work in the textile industry (2-7), although no specific causative agents have been identified. Studies of other industries have found associations between brain tumors and several exposures commonly encountered in the textile industry, including electromagnetic fields (EMF) [see Kheifets (8) and Ahlbom (9) for reviews], solvents (10)(11)(12), metals (10,13,14), and lubricants (15)(16)(17).…”

mentioning

confidence: 99%

Brain tumors and occupational exposures in a cohort of female textile workers in Shanghai, China

Gold¹,

Roos²,

Ray³

et al. 2006

Scand J Work Environ Health

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“…The solvents derived from chlorinated aliphatic hydrocarbons such as tetrachloroethylene, trichloroethylene, carbon tetrachloride, monochloromethane, trichloroethane and dichloromethane are carcinogenic agents 8,9,27,29,30 . In the case-control study, performed by Heinemann et al 29 , six solvents derived from chlorinated aliphatic hydrocarbons, with mutagenic actions, had shown high significant association among astrocytomas and methyl chloride, in a matrix of occupational exposure.…”

Section: Discussionmentioning

confidence: 99%

Nervous system cancer mortality in an industrialized area of Brazil 1980 - 1993

Medrado-Faria

Almeida

Zanetta

et al. 2000

Arq. Neuro-Psiquiatr.

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-Objectives:The industrialization process and nervous system cancer (NSC) mortality in a urban region of Brazil. Method: From registries of the State System of Data Analysis Foundation (SEADE), 103 males deaths by NSC (ICD-9) in Baixada Santista (BS), from 1980 to 1993 were selected. Mortality ratios were calculated comparing the standardized mortality rate for ages over 10 years old (G1) and for the age group from 35 to 64 years old, in the industrialized and non-industrialized areas in three periods : 1980-1993, 1980-86, 1987-93. Results: A statiscally significant high mortality was observed in the industrialized area, for ages over 10 in all periods and only from 1980 to 1993 for ages from 34 to 64. The highest mortality ratio occurred from 1980-86 for ages over 10 -4.12 (CI 1.79-9.42). Conclusion: High mortality was probably related to the environmental and occupational exposure to many organic and inorganic chemical substances, considered carcinogenics, such as aliphatic and aromatic hydrocarbons, organochlorinated, formaldehyde, nitrogenated compounds and heavy metals, found in the port and industrial complex. We discuss the importance of case-control studies in characterizing the association of these and other risk factors in the determination of NSC.KEY WORDS: occupational cancer, cancer mortality, cancer epidemiology, nervous system cancer; brain cancer. Mortalidade por câncer do sistema nervoso em uma área industrializada do Brasil 1980-1993RESUMO -Objetivo: Estudar o processo de industrialização e a mortalidade por câncer do sistema nervoso (CSN) em uma região urbana do Brasil. Método: Foram selecionados dos registros das Fundação Sistema Estadual de Análise de Dados Estatísticos (SEADE), 103 óbitos por CSN (ICD-9) ocorridos na Baixada Santista, no sexo masculino acima dos 10 anos, de 1980 a 1993. Calcularam-se as razões de mortalidade, padronizadas por idade, comparando as áreas industrializada e não industrializada, nos períodos de 1980-93, 1980-96 e 1987-93. Resultados: Observou-se excesso significante de mortalidade na área industrializada para a população acima de 10 anos, em todos os períodos -3.11 ) e 2.63 . Para o grupo de 35-64 anos o excesso ocorreu apenas no período de 1980-93 -2.46 (CI 1.20-5.11). Conclusão: Supõe-se que esse excesso relaciona-se à exposição ocupacional e ambiental a carcinogênicos presentes no complexo industrialportuário como: hidrocarbonetos aromáticos, órgano-clorados, compostos nitrogenados e metais. Estudos casocontrole são necessários para o estudo desses e de outros fatores de risco na determinação do CSN. PALAVRAS-CHAVE: câncer ocupacional, mortalidade por câncer, epidemiologia do câncer, câncer do sistema nervoso.

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Occupational exposure to chlorinated aliphatic hydrocarbons and risk of astrocytic brain cancer

Cited by 76 publications

References 32 publications

Trichloroethylene and cancer: epidemiologic evidence.

Trichloroethylene and cancer: epidemiologic evidence.

Brain tumors and occupational exposures in a cohort of female textile workers in Shanghai, China

Nervous system cancer mortality in an industrialized area of Brazil 1980 - 1993

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