Occupational exposure to hexachlorocyclohexane

Tomczak, Simone E.; Baumann, K.; Lehnert, G.

doi:10.1007/bf00405615

Cited by 27 publications

(7 citation statements)

References 15 publications

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“…Exposed workers in factories producing lindane showed a significant increase in LH, a non-significant increase in FSH, and a slight decrease in testosterone 84 .…”

Section: Pesticidesmentioning

confidence: 88%

“…Studies have shown that lindane can accumulate in the testes, damaging the germinal epithelium and the number of spermatids and Sertoli cells in humans 84 .…”

Section: Pesticidesmentioning

confidence: 99%

“…Endosulfan is a xenoestrogen that is capable of increasing prolactin expression and com-peting with estrogens for the estrogen nuclear receptor 84 . According to Saiyed et al 31 , exposure to endosulfan in boys can delay sexual maturity and interfere with hormone synthesis.…”

Section: Pesticidesmentioning

confidence: 99%

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Occupational exposure and effects on the male reproductive system

2006

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A significant increase in the incidence of male infertility has been described in the international literature, raising questions about its causes. Part of this effect may result from synthetic toxic substances acting on the endocrine system (endocrine disruptors), many of which are routinely used in work processes. We provide a critical review of the specialized literature on work-related chemical substances capable of causing male infertility. Pesticides such as DDT, linuron, and others, heavy metals like mercury, lead, cadmium, and copper, and substances from various industrial uses and residues such as dioxins, polychlorinated biphenyls (PCBs), ethylene dibromide (EDB), phthalates, polyvinyl chloride (PVC), and ethanol are among the main endocrine disruptors that can cause male infertility. Based on the literature, gonadal dysfunction and congenital malformation are the main alterations caused by these substances in the male reproductive system. We conclude that despite the relative lack of studies on this issue, the relevance of such risk calls for further studies as well as measures to prevent workers' exposure to the various substances.

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“…Exposed workers in factories producing lindane showed a significant increase in LH, a non-significant increase in FSH, and a slight decrease in testosterone 84 .…”

Section: Pesticidesmentioning

confidence: 88%

“…Studies have shown that lindane can accumulate in the testes, damaging the germinal epithelium and the number of spermatids and Sertoli cells in humans 84 .…”

Section: Pesticidesmentioning

confidence: 99%

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Occupational exposure and effects on the male reproductive system

2006

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“…Dichlorodiphenyldichloroethane (DDE) for example is a potent androgen antagonist [ 152 ] suppressing spermatogenic epithelium in humans [ 153 ]. Lindane increases LH, FSH, and decreases testosterone but also can accumulate in the testes, impairing germinal epithelium and Sertoli cell function [ 154 ]. Exposure to environmental estrogens (Chlordecone) increases the risk of prostate cancer [ 155 ].…”

Section: Endocrine Disruptors—role In Obesity Related Diseasesmentioning

confidence: 99%

Endocrine Disruptors Leading to Obesity and Related Diseases

Petrakis

Vassilopoulou

Mamoulakis

et al. 2017

IJERPH

159

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The review aims to comprehensively present the impact of exposure to endocrine disruptors (EDs) in relation to the clinical manifestation of obesity and related diseases, including diabetes mellitus, metabolic syndrome, cardiovascular diseases, carcinogenesis and infertility. EDs are strong participants in the obesity epidemic scenery by interfering with cellular morphological and biochemical processes; by inducing inflammatory responses; and by presenting transcriptional and oncogenic activity. Obesity and lipotoxicity enhancement occur through reprogramming and/or remodeling of germline epigenome by exposure to EDs. Specific population groups are vulnerable to ED exposure due to current dietary and environmental conditions. Obesity, morbidity and carcinogenicity induced by ED exposure are an evolving reality. Therefore, a new collective strategic approach is deemed essential, for the reappraisal of current global conditions pertaining to energy management.

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“…However, knowledge of its effects on human health is limited and controversial and in many cases the evidence is based only on studies of workers employed in the production and use of lindane [5]. The most frequently reported effects are related to neurological disorders [6,7], endocrine disruption [8,9], reproductive disorders [10,11], cardiovascular effects [12] and cancer [13,14].…”

Section: Introductionmentioning

confidence: 99%

A biomonitoring study on blood levels of beta-hexachlorocyclohexane among people living close to an industrial area

Porta¹,

Fantini

Felip

et al. 2013

Environ Health

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BackgroundA chemical plant manufacturing pesticides has been operating since the 1950’s in the Sacco River Valley (Central Italy). In 2005, high beta-hexachlorocyclohexane (Beta-HCH) concentrations were found in milk of cows raised and fed near the river. We report the results of a biomonitoring study conducted in this region to evaluate the body burden of Beta-HCH and to identify the determinants of the human contamination.MethodsWe defined four residential areas by their distance from the chemical plant and the river, and selected a stratified random sample of 626 people aged 25–64 years. We evaluated the association, in terms of the geometric mean ratio (GMR), between several potential determinants and Beta-HCH serum concentrations using multivariate linear regression analysis.ResultsTwo hundred forty-six serum samples were analysed to assess Beta-HCH levels (mean concentration: 99 ng/g lipid; Standard Deviation: 121; Geometric Mean: 60.6; Geometric Standard Deviation: 2.65). We found a strong association between Beta-HCH and living in the area close to the river (GMR: 2.00; 95%CI: 1.36-2.94). Beta-HCH levels were also associated with age, level of education, use of private wells and consumption of local food.ConclusionsThe results suggest that people living close to the river may have been contaminated by Beta-HCH, most likely through water from private wells and privately grown food. A programme of epidemiological and clinical surveillance is on-going on this population.

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Occupational exposure to hexachlorocyclohexane

Cited by 27 publications

References 15 publications

Occupational exposure and effects on the male reproductive system

Occupational exposure and effects on the male reproductive system

Endocrine Disruptors Leading to Obesity and Related Diseases

A biomonitoring study on blood levels of beta-hexachlorocyclohexane among people living close to an industrial area

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