Occupational Mortality Matrix: A Tool for Epidemiological Assessment of Work-Related Risk Based on Current Data Sources

Massari, Stefania; Malpassuti, Vittoria; Binazzi, Alessandra; Paris, Lorena; Gariazzo, Claudio; Marinaccio, Alessandro

doi:10.3390/ijerph19095652

Cited by 8 publications

(13 citation statements)

References 36 publications

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“…In Italy, numerous studies have used record linkage methods to estimate the risk of cancer diagnosis and the permanence in a particular economic sector, considering the employment histories acquired from current data sources as a measure of exposure (21,50,51). The use of such type of "electronic data linkage" has been demonstrated as a powerful tool in epidemiological studies such as case-control studies (50), mortality studies (51) and cohort studies (21).…”

Section: Discussionmentioning

confidence: 99%

Cancer mortality and sectors of employment: a cohort study in Italy, 2011-2019

Massari,

Bauleo,

Gariazzo

et al. 2024

Preprint

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Background Cancer is known to be a multifactorial disease, i.e. a combination of multiple factors, such as genetic, environmental, and lifestyle factors influences its development (1, 2). The large impact of occupational exposures on the burden of cancer continues to be a paramount public health concern that deserves more attention. Methods The study aims at evaluating cancer-specific mortality risk in relation to sectors of employment by by using the cohort of Rome Longitudinal Study (ROLs) that has been linked with the National Social Insurance Agency (INPS) database to enrich it with information on working histories. A Cox regression models was used to examine the association between the cancer specific cause of death and the sector of employment in men and women. A similar analysis was performed considering the length of employment (£ 10 years versus ³ 10 years). Results The study population comprised 910,559 (52% of the total population of the cohort after linkage with INPS) 30+ yr employees (53% men and 47% women) followed for a mean period of about 7 million years. The outcomes confirmed some well-known associations (e.g. lung and pleura in construction, pleura in paper and printing, lung and prostate in wood and leather) and suggested possible high-risk sectors that have not been thoroughly investigated yet. In women, we found excess mortality risk in cleaning activities, chemical industry, transport, health services and agriculture. Conclusions The study concludes that occupational exposure in certain industrial sectors significantly influences cancer mortality rates among workers in Italy, in traditional sectors such as construction and wood and leather products and in unexpected sectors e.g. accommodation services and hairdressing. The adopted method proved to be effective in monitoring occupational risks and activating proper prevention initiatives.

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Section: Discussionmentioning

confidence: 99%

Cancer mortality and sectors of employment: a cohort study in Italy, 2011-2019

Massari,

Bauleo,

Gariazzo

et al. 2024

Preprint

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“…This could underestimate the actual prevalence of occupational asbestos exposure in Italy, and consequently the AF of the related cancers. Another reason why the proportion of mesothelioma classified as occupation-related by the ReNaM [ 10 ] is relatively low is that a role is also played by environmental exposure to asbestos [ 77 , 78 , 79 ]. According to our primary estimate of asbestos-related mesotheliomas, including cases of undefined origin, the AF was 86.6%.…”

Section: Discussionmentioning

confidence: 99%

Attributable Fraction of Cancer Related to Occupational Exposure in Italy

Collatuzzo

Turati

Malvezzi

et al. 2023

Cancers

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Background: Exposure to occupational carcinogens is an important and avoidable cause of cancer. We aimed to provide an evidence-based estimate of the burden of occupation-related cancers in Italy. Methods: The attributable fraction (AF) was calculated based on the counterfactual scenario of no occupational exposure to carcinogens. We included exposures classified as IARC group 1 and with reliable evidence of exposure in Italy. Relative risk estimates for selected cancers and prevalences of exposure were derived from large-scale studies. Except for mesothelioma, a 15–20-year latency period between exposure and cancer was considered. The data on cancer incidence in 2020 and mortality in 2017 in Italy were obtained from the Italian Association of Cancer Registries. Results: The most prevalent exposures were UV radiation (5.8%), diesel exhaust (4.3%), wood dust (2.3%) and silica dust (2.1%). Mesothelioma had the largest AF to occupational carcinogens (86.6%), followed by sinonasal cancer (11.8%) and lung cancer (3.8%). We estimated that 0.9% of cancer cases (N~3500) and 1.6% of cancer deaths (N~2800) were attributable to occupational carcinogens in Italy. Of these, about 60% were attributable to asbestos, 17.5% to diesel exhaust, followed by chromium and silica dust (7% and 5%). Conclusions: Our estimates provide up-to-date quantification of the low, but persistent, burden of occupational cancers in Italy.

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“…We used a case-control study based on countrywide mortality data covering the period 2005-2018 [49]. We selected as cases different causes of death likely associated to main occupational risk factors in agriculture including neuro-degenerative and malignant neoplasm.…”

Section: Methodsmentioning

confidence: 99%

Mortality from nervous system diseases and cancer in agriculture workers: a case-control study in Italy

Gariazzo,

Marinaccio,

Consonni

et al. 2024

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Background Population working or living in agriculture settings may experience important exposure to pesticides and other agents. Some health effects associated with them are well known (e.g. skin cancer due to solar radiation) while for others (e.g., neurological diseases and lymphoid, hematopoietic and related tissue cancers) additional epidemiological evidence is needed. We aim to investigate mortality for neurological diseases and cancer in workers employed in agriculture in Italy. Methods We performed a case-control study based on countrywide Italian mortality data 2005–2018 linked with National Social Insurance data to retrieve information on working histories. Adjusted cancer specific mortality odds ratios (MOR) were calculated. We modelled occupational exposure as “ever/never been employed” in agriculture, using the service sectors as reference. Analysis was stratified for gender and length of employment. Results About 64,000 workers employed in agriculture were analyzed in comparison with a control group of 107,000 workers of the service sector. We found elevated risk in agriculture workers for mortality from spinal muscular atrophy (MOR 1.26, 95% CI: 1.03–1.56; 261 deaths) and Parkinson’s disease (PD) (MOR 1.16, 95% CI:1.00-1.34; 742 deaths). As for cancer mortality, positive associations were found for non-follicular lymphoma (NFL) (MOR 1.59, 95% CI: 1.03–2.46; 82 deaths), multiple myeloma (MM) (MOR 1.42, 95% CI: 1.22–1.65; 546 deaths) and myeloid leukemia (ML) (MOR 1.36, 95% CI:1.16–1.60; 474 deaths), as well as for stomach (MOR 1.30, 95% CI:1.20–1.41; 1,732 deaths), prostate (MOR 2.03, 95% CI:1.85–2.24, 1,582 deaths), and brain and central nervous system cancer (MOR 1.30, 95% CI:1.13–1.50, 601 deaths). PD, NFL and ML, as well as cancers of skin, connective and soft tissue, prostate and brain were found to involve mainly men. Conclusions Long-term employment in agriculture was demonstrated associated with several health risks, some of which could be explained by exposure to pesticides. Although the use of the different agronomic categories of pesticides has been changed over time and some active ingredients were prohibited or limited, their health effects remain of concern for their large use, demanding for further focused investigations and preventive measures.

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Occupational Mortality Matrix: A Tool for Epidemiological Assessment of Work-Related Risk Based on Current Data Sources

Cited by 8 publications

References 36 publications

Cancer mortality and sectors of employment: a cohort study in Italy, 2011-2019

Cancer mortality and sectors of employment: a cohort study in Italy, 2011-2019

Attributable Fraction of Cancer Related to Occupational Exposure in Italy

Mortality from nervous system diseases and cancer in agriculture workers: a case-control study in Italy

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