Occupational rhinitis and asthma due to ranitidine

Henriquez-Santana, Aythamy; Bermejo, Sandra Blanco; Ruíz-Hornillos, Javier; Valverde‐Monge, Marcela; Nieto, M. Fernandez

doi:10.1016/j.anai.2016.04.011

Cited by 6 publications

(2 citation statements)

References 7 publications

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“…Cases are also reported for macrolides (spiramicyn, proved by positive SPT and SIC; erythromycin with positive late asthmatic reaction to SIC), tetracycline, thiamphenicol, vancomycin, and colistin (early asthmatic reaction following SIC) [38][39][40]. Case-reports are also published with OA induced by tafenoquine, an antimalarial drug, confirmed by a dual asthmatic reaction following the SIC [41] and ranitidine, an anti-acid medication, with a late asthmatic response after SIC [42]. Even drugs derived from plants like as psyllium, a laxative from Plantago ovata or escin, an active ingredient with anti-inflammatory and venotonic properties found in the horse chestnut, induced OA documented by positive SIC [43,44].…”

Section: Oa-induced By Lmw Sensitizing Agentsmentioning

confidence: 99%

Progress in Occupational Asthma

Tiotiu

Novakova²,

Labor

et al. 2020

IJERPH

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Occupational asthma (OA) represents one of the major public health problems due to its high prevalence, important social and economic burden. The aim of this review is to summarize current data about clinical phenotypes, biomarkers, diagnosis and management of OA, a subtype of work-related asthma. Most studies have identified two phenotypes of OA. One is sensitizer-induced asthma, occuring after a latency period and caused by hypersensitivity to high- or low-molecular weight agents. The other is irritant-induced asthma, which can occur after one or more exposures to high concentrations of irritants without latency period. More than 400 agents causing OA have been identified and its list is growing fast. The best diagnostic approach for OA is a combination of clinical history and objective tests. An important tool is a specific inhalation challenge. Additional tests include assessments of bronchial hyperresponsiveness to methacholine/histamine in patients without airflow limitations, monitoring peak expiratory flow at- and off-work, sputum eosinophil count, exhaled nitric oxide measurement, skin prick tests with occupational allergens and serum specific IgE. Treatment of OA implies avoidance of exposure, pharmacotherapy and education. OA is a heterogeneous disease. Mechanisms of its different phenotypes, their diagnosis, role of new biomarkers and treatment require further investigation.

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Section: Oa-induced By Lmw Sensitizing Agentsmentioning

confidence: 99%

Progress in Occupational Asthma

Tiotiu

Novakova²,

Labor

et al. 2020

IJERPH

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“…Gastric ulcer treatment or prevention is a challenging medical condition facing the scientific community, with limited treatment options. The available anti-ulcer drugs do not treat or prevent gastric ulcer, but they only alleviate symptoms and are usually associated with severe side effects [4,6,7,23]. Thus, it is crucial to introduce new natural antiulcer agents with potent efficacy and a high ▶ safety profile.…”

Section: Discussionmentioning

confidence: 99%

Protective Role of Casuarinin from Melaleuca leucadendra against Ethanol-Induced Gastric Ulcer in Rats

et al. 2019

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Gastric ulcer is a major health problem. Current treatment options of gastric ulcer, including antagonists of histamine H2 receptor and inhibitors of the proton pump, do not cure gastric ulcers, but only provide temporary relief of symptoms and can be associated with severe side effects. The lack of effective and safe medications for this global health problem urges for the discovery of novel classes of compounds with potent activity and an acceptable safety profile. Ethanol-induced ulceration in rats was used to evaluate the gastroprotective activity of casuarinin, an ellagitannin isolated from Melaleuca leucadendra. Casuarinin (25, 50, and 100 mg/kg) reduced the ulcer area by 45, 78, and 99%, respectively, compared with the ulcer group. Casuarinin (100 mg/kg) increased mucin content by 1.8-fold and reduced acidity by 42%. At the same dose, it also increased the levels of reduced glutathione by 194%, catalase by 586%, and prostaglandin E2 to its normal level. In contrast, it attenuated the ethanol-increased levels of malondialdehyde by 56%, TNF-α by 58%, and caspase-3 by 87%. Histological findings demonstrated that casuarinin exhibited a protective effect against tissue alterations in response to the ethanol-induced ulcer. Casuarinin suppressed the immunoexpression of nuclear factor-kappa B, cyclooxygenase-2, and inducible nitric oxide synthase to their normal values. It also induced the expression of heat shock protein-70, reaching up to 4.9-fold in comparison with the ulcer group. The potent gastroprotective effect of casuarinin was thus attributed to its anti-inflammatory, antioxidant, and antiapoptotic effects. Our results suggest the potential application of casuarinin as an antiulcer agent from natural sources.

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Ranitidine

2017

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Occupational rhinitis and asthma due to ranitidine

Cited by 6 publications

References 7 publications

Progress in Occupational Asthma

Progress in Occupational Asthma

Protective Role of Casuarinin from Melaleuca leucadendra against Ethanol-Induced Gastric Ulcer in Rats

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