Occurrence and human health risks of phthalates in indoor air of laboratories

Feng, Yuxi; Feng, Nai-Xian; Zeng, Li-Juan; Chen, Xin; Xiang, Lei; Li, Yanwen; Cai, Quan-Ying

doi:10.1016/j.scitotenv.2019.135609

Cited by 56 publications

(18 citation statements)

References 69 publications

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“…As a vital environmental contaminant, DEHP is used widespread in numerous plastic products, which were found ubiquitously. 39 Many findings provided strong evidence that DEHP hurt the mammalian liver system. Research revealed that DEHP exposure changes glucose intake and transcription of solute carrier family 2 member 2 (GLUT2) in the liver of rats.…”

Section: ■ Discussionmentioning

confidence: 92%

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Lycopene Prevents DEHP-Induced Liver Lipid Metabolism Disorder by Inhibiting the HIF-1α-Induced PPARα/PPARγ/FXR/LXR System

Zhao

Wang³

et al. 2020

J. Agric. Food Chem.

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phthalate (DEHP) is a widespread pollutant that badly affects animals and human health. Lycopene (LYC) has been used as a dietary supplement that has effective antioxidant and antiobesity functions. The present goal was to understand the molecular mechanisms of LYC preventing DEHP-induced lipid metabolism of the liver. The mice were intragastrically administered with LYC (5 mg/kg) and/or DEHP (500 mg/kg or 1000 mg/kg). Here, we found that LYC attenuated DEHP-caused hepatic histopathological lesions including steatosis. Hematological and biochemical analyses revealed that LYC ameliorated DEHP-caused liver function and lipid metabolism disorders. DEHP caused lipid metabolism disorders via activating the peroxisome proliferator activated receptor α/γ (PPARα/γ) signal transducer and Farnesoid X receptor (FXR)/liver X receptor (LXR) signaling pathway. As a major regulator of lipid metabolism, hypoxia-inducible factor-1α (HIF-1α) system was elevated with increased fatty degeneration under DEHP exposure. However, LYC could decrease the levels of HIF-1α/PPARα/PPARγ/FXR/LXR signaling pathway-related factors. Our research indicated that LYC could prevent DEHP-induced lipid metabolism disorders via inhibiting the HIF-1α-mediated PPARα/PPARγ/FXR/LXR system. This study may provide a possible molecular mechanism for fatty liver induced by DEHP.

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Section: ■ Discussionmentioning

confidence: 92%

“…As a vital environmental contaminant, DEHP is used widespread in numerous plastic products, which were found ubiquitously . Many findings provided strong evidence that DEHP hurt the mammalian liver system.…”

Section: Discussionmentioning

confidence: 97%

Lycopene Prevents DEHP-Induced Liver Lipid Metabolism Disorder by Inhibiting the HIF-1α-Induced PPARα/PPARγ/FXR/LXR System

Zhao

Wang³

et al. 2020

J. Agric. Food Chem.

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“…Several studies classified the exposure routes of these EDCs or EEDCs into the human body as ingestion, inhalation, and dermal contact, while several toxic effects, including oxidative stress, disruption in metabolism and energy, translocation, disruption in immune function and neurotoxic and neurodegenerative diseases, were caused [ 17 , 18 , 19 ]. The other findings also showed the exposure routes and mechanism of toxicity through the potential bioaccumulation in human hair, blood, serum, urine, and even in breast milk [ 19 , 20 , 21 , 22 ]. Recent epidemiological studies indicated the effects of PAEs towards gestational diabetes and hypertension among pregnant women and preterm and low birth weight for infants [ 18 , 19 , 20 , 21 , 22 , 23 ].…”

Section: Introductionmentioning

confidence: 99%

“…The other findings also showed the exposure routes and mechanism of toxicity through the potential bioaccumulation in human hair, blood, serum, urine, and even in breast milk [ 19 , 20 , 21 , 22 ]. Recent epidemiological studies indicated the effects of PAEs towards gestational diabetes and hypertension among pregnant women and preterm and low birth weight for infants [ 18 , 19 , 20 , 21 , 22 , 23 ]. Stojanoska et al (2017) revealed that BPA and PAEs were associated with obesity and glucose metabolism disorders [ 24 ].…”

Section: Introductionmentioning

confidence: 99%

Levels of Phthalates, Bisphenol-A, Nonylphenol, and Microplastics in Fish in the Estuaries of Northern Taiwan and the Impact on Human Health

Chao

Mansor

et al. 2021

Toxics

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Due to the sparsity in knowledge, we investigated the presence of various estrogenic endocrine-disrupting chemicals (EEDCs), including phthalates (PAEs), bisphenol-A (BPA), and nonylphenol (NP), as well as microplastics (MPs) in samples of the most widely consumed fish collected from different estuaries in northern Taiwan. We then proceeded to determine the likely contribution that this exposure has on the potential for health impacts in humans following consumption of the fish. Six hundred fish caught from five river estuaries (producing 130 pooled samples) were analyzed to determine how different factors (such as the river, benthic, pelagic, and migratory species) influence EEDCs’ contamination and the possible impacts on human health following typical consumption patterns. The predominant EEDCs was diethyl phthalates (DEP), bis (2-ethylhexyl) phthalates (DEHP), and di-iso-nonylphthalate (DINP) in fish, present at 52.9 ± 77.3, 45.3 ± 79.8, and 42.5 ± 79.3 ng/g dry weight (d.w.), respectively. Residual levels of NP, BPA, and MPs in the fish were 17.4 ± 29.1 and 1.50 ± 2.20 ng/g d.w. and 0.185 ± 0.338 mg/g d.w., respectively. EEDCs and MPs levels varied widely among the five river estuaries sampled due, in part, to differences in habitat types and the associated diversity of fish species sampled. For DEP, the Lao-Jie River and pelagic environments produced the most severely contaminated fish species, respectively. DEP residues were also associated with the burden of MPs in the fish. Based on our analysis, we predict no substantial direct human health risk by EEDCs based on typical consumption rates of estuarine fish by the Taiwanese people. However, other sources of EEDC exposure cannot be ignored.

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“…However, there is still not an air quality strict regulation and their presence in urban air is mostly produced by common anthropogenic sources like intense traffic emissions, and recent studies have demonstrated that car tires wear contribute to release PAHs and other compounds to the ambient air [8][9][10]. Different procedures, based on passive [11,12] as well as active [13][14][15] air sampling, have been proposed for the extraction of different organic pollutants, including PAHs, polychlorinated biphenyls, plasticizers, or flame retardants in air. In most cases, the analytes are trapped onto an appropriate sorbent such as polyurethane foam, XADresin, or carbon-based materials as well as mixtures of different sorbents, followed by thermic or solvent desorption [15][16][17].…”

Section: Introductionmentioning

confidence: 99%

Miniaturized active air sampling method for the analysis of tire rubber pollutants from indoor and outdoor places

Armada

Celeiro

Martinez-Fernandez

et al. 2021

J of Separation Science

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An effective, quick, and sustainable air analysis method was developed to analyze 41 volatiles and semivolatile organic compounds present in tire rubber and crumb rubber materials. The proposed method, based on active sampling using a sorbent material followed by an ultrasound assisted extraction, was developed with the aim of obtaining a fast and simple procedure to determine polycyclic aromatic hydrocarbons, plasticizers, antioxidants, and vulcanization agents in air. A small amount of sorbent (25 mg) was used, and the analytes were recovered in only 1 mL of solvent. An experimental design was applied to study the influence of main factors such as type of sorbent and type of solvent, extraction technique (ultrasound-assisted extraction and vortex extraction), extraction time, as well as the factor interactions. Under optimal conditions, no breakthrough occurs in the studied interval (up to 4 m 3 ). Linearity was demonstrated in a wide concentration range. Accuracy of the total sampling-extraction analysis was evaluated obtaining satisfactory recoveries as well as good precision. The method was successfully applied to different outdoor and indoor air environments, including a recycled rubber synthetic turf football pitch.

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Occurrence and human health risks of phthalates in indoor air of laboratories

Cited by 56 publications

References 69 publications

Lycopene Prevents DEHP-Induced Liver Lipid Metabolism Disorder by Inhibiting the HIF-1α-Induced PPARα/PPARγ/FXR/LXR System

Lycopene Prevents DEHP-Induced Liver Lipid Metabolism Disorder by Inhibiting the HIF-1α-Induced PPARα/PPARγ/FXR/LXR System

Levels of Phthalates, Bisphenol-A, Nonylphenol, and Microplastics in Fish in the Estuaries of Northern Taiwan and the Impact on Human Health

Miniaturized active air sampling method for the analysis of tire rubber pollutants from indoor and outdoor places

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