Occurrence of Cognitive Impairment and Dementia after the Age of 60: A Population-Based Study from Northern Italy

Ronchi, Diana De; Berardi, Domenico; Menchetti, Marco; Ferrari, Giuseppe; Serretti, Alessandro; Dalmonte, E.; Fratiglioni, Laura

doi:10.1159/000082660

Cited by 90 publications

(78 citation statements)

References 94 publications

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“…In accordance with previous studies, the overall prevalence of CI decreased in individuals with higher levels of education [34,35,36]. In our study, 75.2% of participants aged 80 years or more who had <5 years of formal education had CI and 78.5% of illiterate participants had CI.…”

Section: Discussionsupporting

confidence: 92%

Prevalence and Clinical Predictors of Cognitive Impairment in Individuals Aged 80 Years and Older in Rural China

Shi

Zhang²,

Yue³

et al. 2013

Dement Geriatr Cogn Disord

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Aims: The aim of this study was to estimate the prevalence of cognitive impairment (CI) in individuals aged 80 years and over in rural China and to analyze the associated risk factors. Methods: We conducted a two-phase door-to-door survey of a population in rural Ji County (China). The reference population consisted of individuals aged 80 years or older. A total of 723 individuals were interviewed in their homes, and demographic variables and comorbidities were recorded. Diagnoses were divided into the following 3 categories: normal cognitive function, cognitive impairment no dementia (CIND), and dementia. The odds ratio for each risk factor was calculated by logistic regression analysis. Results: The prevalence of CI among individuals aged 80 years and older was 73.2% (47.4% CIND and 25.7% dementia). The risk of CI decreased with a higher level of education and a higher level of social involvement. The risk of CI was higher in females than in males and among people with a history of stroke (p < 0.01). Conclusions: The observed raw prevalence of CI was 73.2%. Female gender and a history of a previous stroke increased the risk of CI, while a higher educational level and engagement in social activities reduced the risk of CI.

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Section: Discussionsupporting

confidence: 92%

Prevalence and Clinical Predictors of Cognitive Impairment in Individuals Aged 80 Years and Older in Rural China

Shi

Zhang²,

Yue³

et al. 2013

Dement Geriatr Cogn Disord

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“…131 controls were selected from the general population of Athens. 59 Italian subjects with a diagnosis of LOAD and 170 healthy controls were recruited in Faenza, Emilia Romagna, Italy, as part of an ongoing study on aging [15, 20]. The subjects were assessed through the administration of the Cambridge Examination for Mental Disorders of Elderly Persons – revised (CAMDEX-R) [21].…”

Section: Methodsmentioning

confidence: 99%

Alzheimer’s Disease and Neurotransmission Gene Variants: Focus on Their Effects on Psychiatric Comorbidities and Inflammatory Parameters

et al. 2019

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Background: Alzheimer’s disease (AD) is a neurodegenerative disorder accounting for 60–70% of dementia cases. Genetic origin accounts for 49–79% of disease risk. This paper aims to investigate the association of 17 polymorphisms within 7 genes involved in neurotransmission (COMT, HTR2A, PPP3CC, RORA, SIGMAR1, SIRT1, and SORBS3) and AD. Methods: A Greek and an Italian sample were investigated, for a total of 156 AD subjects and 301 healthy controls. Exploratory analyses on psychosis and depression comorbidities were performed, as well as on other available clinical and serological parameters. Results: AD was associated with rs4680 within the COMT gene in the total sample. Trends of association were found in the 2 subsamples. Some nominal associations were found for the depressive phenotype. rs10997871 and rs10997875 within SIRT1 were nominally associated with depression in the total sample and in the Greek subsample. rs174696 within COMT was associated with depression comorbidity in the Italian subsample. Discussion: Our data support the role of COMT, and particularly of rs4680, in the pathogenesis of AD. Furthermore, the SIRT1 gene seems to modulate depressive symptomatology in the AD population.

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“…Individuals older than 75 years represent the fastest growing group in developed countries and, in the meantime, the group at the highest risk of dementia [1]. …”

Section: Introductionmentioning

confidence: 99%

Validation Study of the Italian Addenbrooke’s Cognitive Examination Revised in a Young-Old and Old-Old Population

Pigliautile

Ricci

Mioshi

et al. 2011

Dement Geriatr Cogn Disord

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Aims: The main aims of the study were the translation and the subsequent validation in Italian of the Addenbrooke’s Cognitive Examination Revised (ACE-R), and the evaluation of its usefulness in discriminating cognitively normal subjects from patients with mild dementia in an elderly population. Methods: The ACE-R was translated and adapted into Italian. The Italian ACE-R was administered to a group of 179 elderly subjects (72 cognitively healthy and 107 subjects with mild dementia, mean age 75.4 ± 6.4 years). The group was stratified into two subsamples according to age, i.e. a young-old (<75 years) and an old-old (≧75 years) group, in order to evaluate the sensitivity and specificity of the test in detecting dementia in different age strata of elderly subjects. Results: The reliability of the Italian ACE-R was extremely good (α-coefficient = 0.85). Two different cutoffs were identified for young-old (cutoff 79; sensitivity 90% and specificity 80%) and old-old subjects (cutoff 60; sensitivity 82% and specificity 100%). Conclusions: The Italian ACE-R is a valid screening tool to detect dementia, especially in the old-old population, which represents not only the fastest growing age group but also the group at the highest risk of dementia in Western countries.

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Occurrence of Cognitive Impairment and Dementia after the Age of 60: A Population-Based Study from Northern Italy

Cited by 90 publications

References 94 publications

Prevalence and Clinical Predictors of Cognitive Impairment in Individuals Aged 80 Years and Older in Rural China

Prevalence and Clinical Predictors of Cognitive Impairment in Individuals Aged 80 Years and Older in Rural China

Alzheimer’s Disease and Neurotransmission Gene Variants: Focus on Their Effects on Psychiatric Comorbidities and Inflammatory Parameters

Validation Study of the Italian Addenbrooke’s Cognitive Examination Revised in a Young-Old and Old-Old Population

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