Occurrence of fumonisins in food – An interdisciplinary approach to the problem

Waśkiewicz, Agnieszka; Beszterda, Monika; Goliński, Piotr

doi:10.1016/j.foodcont.2012.02.007

Cited by 75 publications

(44 citation statements)

References 90 publications

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“…FB 1 is the most prevalent and toxic among the fumonisins (EFSA, 2005). It is mainly found in maize and maize-based animal feeds (Soriano and Dragacci, 2004;Waskiewicz et al, 2012) and it was present in all rabbit feed samples analysed by Greco et al (2012). Fumonisins inhibit ceramide synthase leading to the accumulation of free sphinganine and sphingosine in the cellular membranes (Riley, 1996).…”

Section: Introductionmentioning

confidence: 99%

Individual and combined effects of feed artificially contaminated with with fumonisin B1 and T-2 toxin in weaned rabbits

Hafner

Szabó

D’Costa

et al. 2016

WMJ

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Co-contamination of feed and feed raw materials with two or more mycotoxins is frequently reported, however, only a few studies have investigated the combined effects of low doses of multiple mycotoxins. In the present study the individual and combined effects of 10 mg/kg fumonisin B 1 and 2 mg/kg T-2 toxin (n=12/group) were investigated in weaned rabbits. Mycotoxin contaminated feed was produced by adding fungal cultures of Fusarium verticillioides and Fusarium sporotrichioides, and fed to 40 days old rabbits during 28 days. Feed intake and body weight were measured weekly, serum biochemistry and antioxidant parameters on day 0, 14 and 28, while histopathological examination and comet assay were performed at the end of the experiment. T-2 exposure both alone and in combination resulted in 15-18% less final body weight compared to the control and FB 1 treatment. There was a significant increase in the concentration of plasma total protein, albumin, fructosamine and creatinine in the group treated with FB 1 compared to the control. The liver and the kidney of most animals treated with T-2 toxin, FB 1 and their combination showed pathological changes, occurring more frequent in animals exposed to both toxins. T-2 resulted in depletion of lymphocytes in the spleen. FB 1 and T-2 exerted synergistic effect on the antioxidant/oxidative parameters after 2 weeks of exposure, manifesting in less glutathione and glutathione peroxidase, while more malondialdehyde was produced. Both toxins caused DNA damage in the lymphocytes, which was more pronounced in the group fed T-2 toxin and T-2 combined with FB 1 , without additive or synergistic effects.

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Section: Introductionmentioning

confidence: 99%

Individual and combined effects of feed artificially contaminated with with fumonisin B1 and T-2 toxin in weaned rabbits

Hafner

Szabó

D’Costa

et al. 2016

WMJ

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“…Consequently, when cereal plants are infected with fungi, there is a risk of the contamination of the grain with mycotoxins and subsequent transfer to feed and food. From a global perspective, three classes of Fusarium mycotoxins are of particular importance in agricultural environments: zearalenone, fumonisins and a range of trichothecenes [13][14][15][16]. Within the trichothecene group, deoxynivalenol (DON) is associated with growth inhibition.…”

Section: Introductionmentioning

confidence: 99%

Toxigenic Fusarium species infecting wheat heads in Poland

et al. 2013

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Toxigenic Fusarium species are common pathogens of wheat and other cereals worldwide. In total, 449 wheat heads from six localities in Poland, heavily infected with Fusarium during 2009 season, were examined for Fusarium species identification. F. culmorum was the most common species (72.1% on average) with F. graminearum and F. avenaceum the next most commonly observed, but much less frequent (13.4 and 12.5% respectively). F. cerealis was found in 1.8% of all samples, and F. tricinctum was found only in one sample (0.2%). Subsequent quantification of the three major mycotoxins (deoxynivalenol, zearalenone and moniliformin) in grain and chaff fractions with respect to associated prevailing pathogen species uncovered the following patterns. Moniliformin (MON) was found in low amounts in all samples with F. avenaceum present. In contrast, deoxynivalenol (DON) and zearalenone (ZEA) were the contaminants of F. culmorum- and F. graminearum-infected heads. The highest concentration of DON was recorded in grain sample collected in Radzików (77 µg g−1). High temperatures in Central Poland during July and August accompanied with high rainfall in July were responsible for this high DON accumulation. Trichothecene, zearalenone, enniatin and beauvericin chemotypes were identified among 21 purified isolates using gene-specific PCR markers.

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“…Among these, toxicologically the most important are FB analogues, which are mainly produced by Fusarium verticillioides and F. proliferatum. More new fumonisins (19)(20)(21) have been detected using liquid chromatography/electrospray ionisation ion-trap multistage mass spectrometry (MS) but only three of them [fumonisin B 1 (FB 1 ), B 2 (FB 2 ), and B 3 (FB 3 )] seem to occur more frequently (22). Fumonisins (FBs) are structurally similar to sphinganine and they disrupt sphingolipid metabolism by inhibiting ceramide synthase -a process underlying the mechanism of toxicity and the pathogenesis of fumonisin-related diseases (23).…”

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Mycotoxins Biosynthesized by Plant-Derived Fusarium Isolates / Tvorba Mikotoksina U Vrstama Roda Fusarium Izoliranim Iz Biljaka

Waśkiewicz

Stępień

2012

Archives of Industrial Hygiene and Toxicology

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There is little information on secondary metabolites produced by Fusaria infecting crop plants other than cereals. Many members of Fusarium genus have the ability to colonise perennial crops with only scarce infection or disease symptoms or with no symptoms at all while still being detectable. Even in case of such asymptomatic infection, significant mycotoxin contamination of the plant tissues is possible. The aim of this study was to characterise the spectrum of Fusarium species isolates obtained from different plant hosts (like asparagus, garlic, pineapple, banana, rhubarb, peppers, rice, maize, wheat, and oncidium) and evaluate their ability to biosynthesize the most common mycotoxins in vitro. Among the F.proliferatum isolates, up to 57 % of them biosynthesized fumonisins at very high mass fractions, amounting to above 1000 μg g-1, while other Fusarium species such as F. verticillioides, F. lactis, F. polyphialydicum, F. concentricum, F. temperatum, and F. fujikuroi formed fumonisins mostly at much lower level. Only F.ananatum and F. oxysporum did not produce these toxins. Co-occurrence of FBs with other mycotoxins [moniliformin (MON) and beauvericin (BEA)] was often observed and it was mainly F. proliferatum species that formed both mycotoxins (0.4 μg g-1 to 41.1 μg g-1 BEA and 0.1 μg g-1 to 158.5 μg g-1 MON).

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Occurrence of fumonisins in food – An interdisciplinary approach to the problem

Cited by 75 publications

References 90 publications

Individual and combined effects of feed artificially contaminated with with fumonisin B1 and T-2 toxin in weaned rabbits

Individual and combined effects of feed artificially contaminated with with fumonisin B1 and T-2 toxin in weaned rabbits

Toxigenic Fusarium species infecting wheat heads in Poland

Mycotoxins Biosynthesized by Plant-Derived Fusarium Isolates / Tvorba Mikotoksina U Vrstama Roda Fusarium Izoliranim Iz Biljaka

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