Ochratoxin A as an alarming health threat for livestock and human: A review on molecular interactions, mechanism of toxicity, detection, detoxification, and dietary prophylaxis

Li, Wenchao; Pushparaj, Karthika; Meyyazhagan, Arun; Arumugam, Vijaya Anand; Pappuswamy, Manikantan; Bhotla, Haripriya Kuchi; Baskaran, Rathinasamy; Issara, Utthapon; Balasubramanian, Balamuralikrishnan; Khaneghah, Amin Mousavi

doi:10.1016/j.toxicon.2022.04.012

Cited by 45 publications

(22 citation statements)

References 169 publications

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“…Naturally occurring in all major cereal grains, cocoa, and other foods, unfortunately, OTA can pose severe toxicity to many animal species upon ingestion, including kidney damage, liver necrosis, and enteritis. 1,2 Insights from metabolism also argue that OTA exhibits genotoxic activity via oxidative damage and can induce carcinogenesis (IARC Group 2B). 3 According to a survey of OTA exposure in the European diet, cereals and cereal derivatives represent the food groups contributing the most to OTA exposure.…”

Section: Introductionmentioning

confidence: 99%

Suppressed DNA base pair stacking assembly of gold nanoparticles in an alcoholic solvent for enhanced ochratoxin A detection in Baijiu

Chen

Ding

et al. 2023

Analyst

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Section: Introductionmentioning

confidence: 99%

Suppressed DNA base pair stacking assembly of gold nanoparticles in an alcoholic solvent for enhanced ochratoxin A detection in Baijiu

Chen

Ding

et al. 2023

Analyst

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“…The TK of OTA in laboratory animals, humans and some target species has been recently detailed in the EFSA 2020 Opinion, based on the reviews by Ringot et al (2006), Vettorazzi et al (2014), Heussner and Bingle (2015) and K € oszegi and Poor (2016). For more recent reviews see Tao et al (2018) and Liu et al (2022). The main steps of OTA kinetics are summarised in the following paragraphs.…”

Section: Hazard Identification and Characterisationmentioning

confidence: 99%

Risks for animal health related to the presence of ochratoxin A (OTA) in feed

Schrenk,

Bignami,

Bodin

et al. 2023

EFS2

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In 2004, the EFSA Panel on Contaminants in the Food Chain (CONTAM) adopted a Scientific Opinion on the risks to animal health and transfer from feed to food of animal origin related to the presence of ochratoxin A (OTA) in feed. The European Commission requested EFSA to assess newly available scientific information and to update the 2004 Scientific Opinion. OTA is produced by several fungi of the genera Aspergillus and Penicillium. In most animal species it is rapidly and extensively absorbed in the gastro-intestinal tract, binds strongly to plasma albumins and is mainly detoxified to ochratoxin alpha (OTalpha) by ruminal microbiota. In pigs, OTA has been found mainly in liver and kidney. Transfer of OTA from feed to milk in ruminants and donkeys as well as to eggs from poultry is confirmed but low. Overall, OTA impairs function and structure of kidneys and liver, causes immunosuppression and affects the zootechnical performance (e.g. body weight gain, feed/gain ratio, etc.), with monogastric species being more susceptible than ruminants because of limited detoxification to OTalpha. The CONTAM Panel considered as reference point (RP) for adverse animal health effects: for pigs and rabbits 0.01 mg OTA/kg feed, for chickens for fattening and hens 0.03 mg OTA/kg feed. A total of 9,184 analytical results on OTA in feed, expressed in dry matter, were available. Dietary exposure was assessed using different scenarios based on either model diets or compound feed (complete feed or complementary feed plus forage). Risk characterisation was made for the animals for which an RP could be identified. The CONTAM Panel considers that the risk related to OTA in feed for adverse health effects for pigs, chickens for fattening, hens and rabbits is low.

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“…Ochratoxin A (OTA) is a fungal toxin widely present in various foods and feeds and is able to lead to multiple organ toxicity (Khoi et al, 2021). The mechanism of OTA toxicity involves metabolic dysfunction, exacerbation of membrane lipid peroxidation, cessation of mitochondrial respiration, and induction of DNA damage, thereby producing ROS and inducing oxidative stress (Liu et al, 2022). H 2 O 2 has been used as a positive control in the current investigation.…”

Section: Pharmacological Manipulation Of Quercetin On Rosmentioning

confidence: 99%

Advance in the pharmacological effects of quercetin in modulating oxidative stress and inflammation related disorders

Zhou

Qian

Tang

et al. 2023

Phytotherapy Research

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Numerous pharmacological effects of quercetin have been illustrated, including antiinflammation, antioxidation, and anticancer properties. In recent years, the antioxidant activity of quercetin has been extensively reported, in particular, its impacts on glutathione, enzyme activity, signaling transduction pathways, and reactive oxygen species (ROS). Quercetin has also been demonstrated to exert a striking antiinflammatory effect mainly by inhibiting the production of cytokines, reducing the expression of cyclooxygenase and lipoxygenase, and preserving the integrity of mast cells. By regulating oxidative stress and inflammation, which are regarded as two critical processes involved in the defense and regular physiological operation of biological systems, quercetin has been validated to be effective in treating a variety of disorders. Symptoms of these reactions have been linked to degenerative processes and metabolic disorders, including metabolic syndrome, cardiovascular, neurodegeneration, cancer, and nonalcoholic fatty liver disease. Despite that evidence demonstrates that antioxidants are employed to prevent excessive oxidative and inflammatory processes, there are still concerns regarding the expense, accessibility, and side effects of agents. Notably, natural products, especially those derived from plants, are widely accessible, affordable, and generally safe. In this review, the antioxidant and antiinflammatory abilities of the active ingredient quercetin and its application in oxidative stress‐related disorders have been outlined in detail.

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Ochratoxin A as an alarming health threat for livestock and human: A review on molecular interactions, mechanism of toxicity, detection, detoxification, and dietary prophylaxis

Cited by 45 publications

References 169 publications

Suppressed DNA base pair stacking assembly of gold nanoparticles in an alcoholic solvent for enhanced ochratoxin A detection in Baijiu

Suppressed DNA base pair stacking assembly of gold nanoparticles in an alcoholic solvent for enhanced ochratoxin A detection in Baijiu

Risks for animal health related to the presence of ochratoxin A (OTA) in feed

Advance in the pharmacological effects of quercetin in modulating oxidative stress and inflammation related disorders

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