Octreotide Long-Acting Repeatable for the Treatment of Chronic Macular Edema in Uveitis

Missotten, Tom; Laar, Jan A. M. van; Loos, T L van der; Daele, Paul L A van; Kuijpers, Robert W A M; Baarsma, G. S.; Hagen, P. Martin van

doi:10.1016/j.ajo.2007.07.039

Cited by 28 publications

(13 citation statements)

References 39 publications

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“…A few studies have shown that the use of octreotide or other somatostatin analogs can lead to a reduction in macular edema. This is often associated with a reduction in the need for adjunctive anti-inflammatory medication (Missotten et al, 2007;Papadaki et al, 2005;Kuijpers et al, 1998) [77][78][79] . The mechanism of action is through an enhanced apical-basal fluid transport through the RPE.…”

Section: Rpe Pump Stimulatorsmentioning

confidence: 98%

“…The mechanism of action is through an enhanced apical-basal fluid transport through the RPE. The initial response is observed within a mean of about 3 months of continuous treatment (Missotten et al, 2007) 77 . The medication can be discontinued in some patients after several months of use (12-24 months), but recurrences are frequent.…”

Section: Rpe Pump Stimulatorsmentioning

confidence: 99%

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Cystoid Macular Edema in Uveitis

Smet¹,

Okada²

2010

Developments in Ophthalmology

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Macular edema is a major cause of morbidity in uveitis patients. Inflammatory mediators act on the integrity of the blood ocular barrier and on the function of the RPE pump. Chronicity leads to irreversible changes and is reported to cause up to 30% of permanent visual loss in uveitis patients. Assessing the presence and severity of edema with appropriate investigational techniques (Spectral domain OCT, and angiography) help to determine its reversibility and define a therapeutic strategy wherein intraocular steroids play a key role while RPE pump stimulators and surgery are restricted to more severe disease or the presence of tractional syndromes.

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Section: Rpe Pump Stimulatorsmentioning

confidence: 98%

Section: Rpe Pump Stimulatorsmentioning

confidence: 99%

Cystoid Macular Edema in Uveitis

Smet¹,

Okada²

2010

Developments in Ophthalmology

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“…Missoten et al 4 SST may also have a role in retinal physiology. Kouvidi et al 24 reported that SST causes an increase in dopamine release in rat retinal explants.…”

Section: Discussionmentioning

confidence: 99%

“…3 SST and its receptors are expressed in the uvea, retinal pigment epithelium (RPE) and neuroretina, and the receptors are expressed in the vascular endothelium. [4][5][6] A role for SST in the maintenance of blood-retinal barrier integrity has been suggested based on its positive effect on apical-to-basal fluid transport across RPE cells. 4 In a previous study, we found lower vitreous levels and lower intraocular production of SST in patients with diabetic macular oedema, suggesting that SST deficit may contribute to oedema formation.…”

Section: Introductionmentioning

confidence: 99%

“…[4][5][6] A role for SST in the maintenance of blood-retinal barrier integrity has been suggested based on its positive effect on apical-to-basal fluid transport across RPE cells. 4 In a previous study, we found lower vitreous levels and lower intraocular production of SST in patients with diabetic macular oedema, suggesting that SST deficit may contribute to oedema formation. 7 In addition, we showed that retinal neurodegeneration, which occurs before vascular alterations develop, could be responsible for the decreased SST production in diabetic patients.…”

Section: Introductionmentioning

confidence: 99%

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Vitreous levels of somatostatin in patients with chronic uveitic macular oedema

Fonollosa

Coronado

Catalán

et al. 2012

Eye

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Purpose Intravitreal somatostatin (SST) levels are decreased in patients with diabetic macular oedema. This deficit may be involved in the pathogenesis of this condition. The aim of the present study was to determine SST concentration in the vitreous fluid of patients with chronic uveitic macular oedema (CUMO) and quiescent intraocular inflammation. Methods Plasma and vitreous fluid samples were obtained during vitrectomy from 11 eyes of patients with CUMO and from 42 eyes of control subjects (idiopathic epiretinal membrane, macular hole). SST concentration was measured by radioimmunoassay. Statistics: w 2 -square test, Mann-Whitney U-test, Wilcoxon test, Spearman's rank correlation coefficient, and multivariant linear regression models. Results Plasma SST concentrations were similar in uveitic patients and controls (28.25 pg/ml (21.3-31) vs 28.7 pg/ml (22-29.5); P ¼ 0.869). A higher vitreous concentration of proteins was found in uveitic patients (1.59 ± 0.38 mg/ml vs 0.73 ± 0.32 mg/ml, Po0.0001). Vitreous SST was markedly lower in uveitic patients, both in absolute terms and after adjusting for total intravitreous protein concentration (39.37 pg/ml (6.16-172) vs 486.73 pg/ml (4.7-1833), Po0.0001; 33.1 pg/mg (3.9-215.74) vs 629.75 pg/mg (6.91-2024), Po0.0001). No correlations were found between plasma and vitreous concentration of SST in either group (r ¼ 0.191, P ¼ 0.57 and r ¼ 0.49, P ¼ 0.66). There were no correlations between vitreous SST concentration and visual acuity or macular thickness in uveitic patients (r ¼ 0.302, P ¼ 0.31 and r ¼ 0.45, P ¼ 0.13). Conclusions Intravitreous SST is decreased in patients with CUMO and quiescent intraocular inflammation. The deficit of SST may have a role in the pathogenesis of this condition.

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Œdème maculaire cystoïde dans les uvéites

Smet

Okada

2011

Œdèmes Maculaires

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Octreotide Long-Acting Repeatable for the Treatment of Chronic Macular Edema in Uveitis

Cited by 28 publications

References 39 publications

Cystoid Macular Edema in Uveitis

Cystoid Macular Edema in Uveitis

Vitreous levels of somatostatin in patients with chronic uveitic macular oedema

Œdème maculaire cystoïde dans les uvéites

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