Ocular Blood Flow Analysis Detects Microvascular Abnormalities in Impaired Glucose Tolerance

Quinn, Cathy E.; Hamilton, Paul; McCann, Aaron; Agnew, Christina; Millar, Auleen; Lockhart, Christopher; Harbinson, Mark; McVeigh, Gary E.

doi:10.1111/j.1549-8719.2011.00110.x

Cited by 4 publications

(5 citation statements)

References 41 publications

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“…This finding is in contrast to other studies demonstrating that WT analysis is superior in detecting microvascular abnormalities in other vascular beds such as the retinal circulation [16,20]. This finding may be the consequence of the post-processing process required to undertake WT analysis in the current work.…”

Section: Discussioncontrasting

confidence: 55%

“…This approach yields information such as RI, PI, notches, troughs and peaks which does not permit a comprehensive analysis of Doppler flow velocities over the entire cardiac cycle. This approach fails to identify significant changes in the waveform contour that may be indicative of structural or functional changes in downstream vascular beds [14,19,20]. The precise physiological origin of these features on waveforms has proved difficult to elucidate, but it is widely appreciated that such approaches ignore the vast majority of information contained in the signal.…”

Section: Discussionmentioning

confidence: 99%

“…Time-frequency domain analysis such as the WT reported in this paper describes the component frequencies that make up any particular waveform. There is no direct correlation between certain frequencies and obvious features such as notches on the waveform [14,15,16,19,20]. …”

Section: Discussionmentioning

confidence: 99%

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Comparison of Wavelet Transform and Time-Domain Analysis of Second Trimester Uterine Artery Doppler Waveforms in Screening for Pre-Eclampsia

D’Antonio

Hamilton²,

Pinnock³

et al. 2013

Fetal Diagn Ther

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The aim of this study was to compare time-domain waveform analysis of second-trimester uterine artery Doppler using the resistance index (RI) with waveform analysis using a mathematical tool known as wavelet transform for the prediction of pre-eclampsia (PE). This was a retrospective, nested case-cohort study of 336 women, 37 of whom subsequently developed PE. Uterine artery Doppler waveforms were analysed using both RI and waveform analysis. The utility of these indices in screening for PE was then evaluated using receiver operating characteristic curves. There were significant differences in uterine artery RI between the PE women and those with normal pregnancy outcome. After wavelet analysis, significant difference in the mean amplitude in wavelet frequency band 4 was noted between the 2 groups. The sensitivity for both Doppler RI and frequency band 4 for the detection of PE at a 10% false-positive rate was 45%. This small study demonstrates the application of wavelet transform analysis of uterine artery Doppler waveforms in screening for PE. Further prospective studies are needed in order to clearly define if this analytical approach to waveform analysis may have the potential to improve the detection of PE by uterine artery Doppler screening.

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Section: Discussioncontrasting

confidence: 55%

Section: Discussionmentioning

confidence: 99%

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Comparison of Wavelet Transform and Time-Domain Analysis of Second Trimester Uterine Artery Doppler Waveforms in Screening for Pre-Eclampsia

D’Antonio

Hamilton²,

Pinnock³

et al. 2013

Fetal Diagn Ther

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“…They were included as comparators in this study as they are widely quoted and understood, being often displayed directly on ultrasound scanner screens now. These measures have been used extensively in the analysis of Doppler blood flow waveforms and yet their limitations have been equally well documented [ 12 , 15 - 19 ]. As single domain methods, it has been suggested that they lack the necessary flexibility to adequately assess an entity as variable as the blood flow waveform.…”

Section: Discussionmentioning

confidence: 99%

Ultrasound entropy may be a new non-invasive measure of pre-clinical vascular damage in young hypertensive patients

Bleakley

McCann²,

McClenaghan³

et al. 2015

Cardiovasc Ultrasound

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BackgroundThe identification of pre-clinical microvascular damage in hypertension by non-invasive techniques has proved frustrating for clinicians. This proof of concept study investigated whether entropy, a novel summary measure for characterizing blood velocity waveforms, is altered in participants with hypertension and may therefore be useful in risk stratification.MethodsDoppler ultrasound waveforms were obtained from the carotid and retrobulbar circulation in 42 participants with uncomplicated grade 1 hypertension (mean systolic/diastolic blood pressure (BP) 142/92 mmHg), and 26 healthy controls (mean systolic/diastolic BP 116/69 mmHg). Mean wavelet entropy was derived from flow-velocity data and compared with traditional haemodynamic measures of microvascular function, namely the resistive and pulsatility indices.ResultsEntropy, was significantly higher in control participants in the central retinal artery (CRA) (differential mean 0.11 (standard error 0.05 cms−1), CI 0.009 to 0.219, p 0.017) and ophthalmic artery (0.12 (0.05), CI 0.004 to 0.215, p 0.04). In comparison, the resistive index (0.12 (0.05), CI 0.005 to 0.226, p 0.029) and pulsatility index (0.96 (0.38), CI 0.19 to 1.72, p 0.015) showed significant differences between groups in the CRA alone. Regression analysis indicated that entropy was significantly influenced by age and systolic blood pressure (r values 0.4-0.6). None of the measures were significantly altered in the larger conduit vessel.ConclusionThis is the first application of entropy to human blood velocity waveform analysis and shows that this new technique has the ability to discriminate health from early hypertensive disease, thereby promoting the early identification of cardiovascular disease in a young hypertensive population.Clinical trial registrationClinical Trials.gov, NCT01047423

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“…1,2 Interventions on the life of people with IGT could delay the onset of type 2 diabetes, reduce microvascular complications, the incidence of cardiovascular and all-cause mortality, and extend life expectancy. 3,4 It was known that IGT could cause changes in renal microcirculation, [5][6][7] retinal microcirculation, 8 myocardial microcirculation 9 and skeletal muscle perfusion. 9,10 However, as far as the authors were concerned, there was no relevant report on foot microcirculation of IGT patients.…”

Section: Introductionmentioning

confidence: 99%

Assessment of Microcirculation in the Type 2 Diabetic and Impaired Glucose Tolerance Feet of Elderly Men by CEUS

Li¹,

Wu²,

Yang³

et al. 2021

DMSO

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Objective To evaluate the foot microcirculation in type 2 diabetes mellitus (T2DM) and impaired glucose tolerance patients (IGT) with contrast-enhanced ultrasound (CEUS). Methods The study included 37 patients with T2DM but without diabetic foot (DM group), 15 patients with impaired glucose tolerance (IGT group) and 10 elderly males with normal fasting blood glucose (FBS) and negative glucose tolerance tests (control group). Color Doppler flow imaging (CDFI) and CEUS were performed on the right foot great toes for detecting the blood perfusion performance. CEUS images were recorded and parameters of CDFI and flow time-intensity curves (TICs) were analyzed by the Student’s t -test. Results There was no significant difference in CDFI parameters pulse index and peak systolic blood flow velocity (PSV) among the three groups (P >0.05). Compared with control group, CEUS images of IGT and DM groups showed lower microvascular density and were pale. Peak intensity (PI) and area under time-intensity curve (AUC) in control, IGT and DM groups were decreased gradually (PI 46.36±10.96 vs 35.26±11.65 vs 28.15±7.94, P = 0.001, AUC 5.12±1.02 vs 3.25±1.60 vs 2.81±1.20, P = 0.001). The arrival times (AT) and time to peak (TTP) tended to be increased with the extension of DM course, but the difference was not statistically significant (AT, P = 0.260, TTP, P = 0.481). Conclusion CEUS, as a noninvasive and valuable technique, could detect the alterations in foot microcirculation of DM and IGT patients.

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Ocular Blood Flow Analysis Detects Microvascular Abnormalities in Impaired Glucose Tolerance

Abstract: Analysis of ocular Doppler flow waveforms using the discrete wavelet transform identified microvascular abnormalities that were not apparent using RI. Pioglitazone improved glucose, insulin sensitivity, and triglycerides without influencing the contour of the waveforms.

Cited by 4 publications

References 41 publications

Comparison of Wavelet Transform and Time-Domain Analysis of Second Trimester Uterine Artery Doppler Waveforms in Screening for Pre-Eclampsia

Comparison of Wavelet Transform and Time-Domain Analysis of Second Trimester Uterine Artery Doppler Waveforms in Screening for Pre-Eclampsia

Ultrasound entropy may be a new non-invasive measure of pre-clinical vascular damage in young hypertensive patients

Assessment of Microcirculation in the Type 2 Diabetic and Impaired Glucose Tolerance Feet of Elderly Men by CEUS

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