Ocular Components Measured by Keratometry, Phakometry, and Ultrasonography in Emmetropic and Myopic Optometry Students

Goss, David A.; Veen, Heleen; Rainey, Bill B.; Feng, Bo

doi:10.1097/00006324-199707000-00015

Cited by 77 publications

(54 citation statements)

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“…Also, several studies [56][57][58][59][60] have shown the tendency for females to have steeper corneas than males due to their shorter axial length. Goh and Lam 53 found that Hong Kong Chinese men aged 19-39 years had flatter corneal curvature than women of a similar age range in the same study.…”

Section: Gendermentioning

confidence: 99%

A review of corneal diameter, curvature and thickness values and influencing factors*

Mashige

2013

African Vision and Eye Health

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The cornea is an important ocular structure involved in the mediation of visual perception. It is the principal refractive surface of the eye and vision can be significantly affected by relatively small changes in its structure and parameters. Measurement of corneal parameters is important in the diagnosis and management of ocular diseases such as keratoconus and glaucoma, and also in the fitting of contact lenses or with refractive surgery such as Laser-Assisted in situ Keratomileusis (LASIK) and photorefractive keratectomy (PRK). The human corneal diameter, anterior curvature and centre thickness as well as factors influencing them are reviewed in this article. This review will be useful to eye care professionals who routinely measure these parameters when fitting contact lenses and assessing, diagnosing as well as managing corneal and other ocular conditions. (S Afr Optom 2013 72(4) [185][186][187][188][189][190][191][192][193][194]

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Section: Gendermentioning

confidence: 99%

A review of corneal diameter, curvature and thickness values and influencing factors*

Mashige

2013

African Vision and Eye Health

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“…Therefore, the clinical assessment of high myopia is crucial for minimizing the disease heterogeneity which may confound the association study. High myopia is mainly due to the elongation of axial length, which is the primary ocular component found to be under genetic control (Goss et al, 1997). The strong correlation between axial length and refractive error in diopters demonstrates that the major ocular component for our myopic subjects is axial length, not other ocular refractive components such as corneal power (Han et al, 2006).…”

Section: Discussionmentioning

confidence: 86%

Investigation of the association between all-trans-retinol dehydrogenase (RDH8) polymorphisms and high myopia in Chinese

Wang

Shen

et al. 2010

J. Zhejiang Univ. Sci. B

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Retinoic acid level in the retina/choroid is altered in induced myopia models. All-trans-retinol dehydrogenase (RDH8) is an important enzyme of retinoic acid metabolism. This study aimed to investigate the association of the RDH8 gene with high myopia. Three single nucleotide polymorphisms (SNPs) [RDH851 (rs2233789), RDH8E5a (rs1644731), and RDH855b (rs3760753)] were selected, based on the linkage disequilibrium pattern of RDH8 from a previous study, and genotyped for 160 Han Chinese nuclear families with highly myopic (−10 diopters or worse) offspring as well as in an independent group with 166 highly myopic cases (−10 diopters or worse) and 211 controls. Family-based association analysis was performed using the family-based association test (FBAT) package, and genotype relative risk (GRR) was calculated using the GenAssoc program. Population-based association analysis was performed using Chi-square test. These SNPs were in linkage equilibrium with each other. SNPs RDH851 (rs2233789) and RDH8E5a (rs1644731) both did not show association with high myopia. SNP RDH855b (rs3760753) demonstrated significant association (P=0.0269) with a GRR of 0.543 (95% confidence interval=0. 304-0.968, P=0.038). The association became statistically insignificant, however, after multiple comparison correction. Haplotype analysis did not show a significant association either. Population-based association analysis also showed no significant association (P>0.05). Our family-and population-based data both suggest that the RDH8 gene is unlikely to be associated with high myopia in Chinese.

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“…These confounding factors may compromise the statistical efficiency of the association test and be responsible for the equivocal results observed in different myopia genetic studies (Farbrother et al, 2004;Hysi et al, 2014). It is well known that the elongation of AXL is the primary ocular component contributing to high myopia and has the strongest genetic component (Goss et al, 1997). The strongest correlation between AXL and SE for our subjects could also provide a strong and homogeneous genetic background for the cases in this study (Han et al, 2009).…”

Section: Entry Criteria and Phenotypingmentioning

confidence: 78%

Controversial opinion: evaluation of EGR1 and LAMA2 loci for high myopia in Chinese populations

Lin

Huang

Lü

et al. 2016

J. Zhejiang Univ. Sci. B

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Abstract:Functional studies have suggested the important role of early growth response 1 (EGR1) and Laminin α2-chain (LAMA2) in human eye development. Genetic studies have reported a significant association of the single nucleotide polymorphism (SNP) in the LAMA2 gene with myopia. This study aimed to evaluate the association of the tagging SNPs (tSNPs) in the EGR1 and LAMA2 genes with high myopia in two independent Han Chinese populations. Four tSNPs (rs11743810 in the EGR1 gene; rs2571575, rs9321170, and rs1889891 in the LAMA2 gene) were selected, according to the HapMap database (http://hapmap.ncbi.nlm.nih.gov), and were genotyped using the ligase detection reaction (LDR) approach for 167 Han Chinese nuclear families with extremely highly myopic offspring (<−10.0 diopters) and an independent group with 485 extremely highly myopic cases (<−10.0 diopters) and 499 controls. Direct sequencing was used to confirm the LDR results in twenty randomly selected subjects. Family-based association analysis was performed using the family-based association test (FBAT) software package (Version 1.5.5). Population-based association analysis was performed using the Chi-square test. The association analysis power was estimated using online software (http://design.cs.ucla.edu). The FBAT demonstrated that all four tSNPs tested did not show association with high myopia (P>0.05). Haplotype analysis of tSNPs in the LAMA2 genes also did not show a significant association (P>0.05). Meanwhile, population-based association analysis also showed no significant association results with high myopia (P>0.05). On the basis of our family-and population-based analyses for the Han Chinese population, we did not find positive association signals of the four SNPs in the LAMA2 and EGR1 genes with high myopia.

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Ocular Components Measured by Keratometry, Phakometry, and Ultrasonography in Emmetropic and Myopic Optometry Students

Cited by 77 publications

References 0 publications

A review of corneal diameter, curvature and thickness values and influencing factors*

A review of corneal diameter, curvature and thickness values and influencing factors*

Investigation of the association between all-trans-retinol dehydrogenase (RDH8) polymorphisms and high myopia in Chinese

Controversial opinion: evaluation of EGR1 and LAMA2 loci for high myopia in Chinese populations

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