Ocular immunosuppressive microenvironment and novel drug delivery for control of uveitis

Teabagy, Sean; Wood, Emma; Bilsbury, Evan; Doherty, Sean; Janardhana, Priya; Lee, Darren J.

doi:10.1016/j.addr.2023.114869

Cited by 7 publications

(1 citation statement)

References 111 publications

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“…[31] Although Adalimumab confers greater advantages than corticosteroids, systemic treatment or intravitreal injection of the drug carries significant risks such as immunosuppression or retinal detachment. [52] In addition, patients are often reluctant to receive such invasive treatment to the eye, resulting in low treatment efficacy. In the present study, the researchers aimed to provide a non-invasive therapy that can achieve a high Adalimumab permeation rate.…”

Section: Uveitismentioning

confidence: 99%

Smart molecules in ophthalmology: Hydrogels as responsive systems for ophthalmic applications

Kulbay,

Wu,

Truong

et al. 2024

Smart Molecules

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This comprehensive review delves into a unique intersection of hydrogels as smart molecules and their transformative applications in ophthalmology. Beginning with the foundational definition, properties, and classification of hydrogels, the review explores their synthesis and responsive capabilities. Specific applications examined encompass topical drug delivery, contact lenses, intravitreal drug delivery, ocular adhesives, vitreous substitutes, and cell‐based therapy. A methodical analysis, including an overview of relevant ocular structures and a comparative evaluation of hydrogel‐based solutions against traditional treatments, is conducted. Additionally, potential constraints, translation challenges, knowledge gaps, and research areas are identified. Our methodical approach, guided by an extensive literature review from 2017 to 2023, illuminates the unprecedented opportunities offered by hydrogels, along with pinpointing areas for further inquiry to facilitate their transition into clinical practice.

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Section: Uveitismentioning

confidence: 99%

Smart molecules in ophthalmology: Hydrogels as responsive systems for ophthalmic applications

Kulbay,

Wu,

Truong

et al. 2024

Smart Molecules

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Liposome‐Based Permeable Eyedrops for Effective Posterior Segment Drug Delivery

Wang,

Hu,

et al. 2024

Adv Funct Materials

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Topical eyedrop administration is identified as an ideal non‐invasive strategy for ocular drug delivery. However, multiple complex ocular barriers greatly restrict their effectiveness in the treatment of posterior ocular disease. Herein, a liposome‐based permeable eyedrops (pDrops) capable of overcoming multiple ocular barriers and achieving efficient posterior drug delivery is presented. pDrops have a core‐shell structure in which drugs are encapsulated inside the liposome core with a chitosan shell. This chitosan coating significantly enhances the pDrops’ binding to mucin in tears and facilitates the temporary opening of tight junctions in cornea/conjunctive epithelial cells, thereby achieving prolonged preocular retention and enhanced posterior segment drug delivery. In this study, hydrophilic ganciclovir (GCV) and hydrophobic curcumin (CUR) are employed as model drugs. Upon topical instillation, pDrops effectively overcome ocular barriers and delivered GCV to the posterior segment in both rat and rabbit eyes. Notably, CUR delivery by pDrops demonstrates significantly enhanced therapeutic efficacy in light‐damaged retina of mice. Considering that pDrops can deliver both hydrophobic and hydrophilic drugs to the posterior segment of the eye, it can potentially become a feasible platform for the non‐invasive delivery of various drug molecules and improve the treatment efficiency of posterior ocular diseases.

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Blood-Retinal Barrier

Fernandes,

Cunha-Vaz

2024

Reference Module in Neuroscience and Biobehavioral Psychology

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Ocular immunosuppressive microenvironment and novel drug delivery for control of uveitis

Cited by 7 publications

References 111 publications

Smart molecules in ophthalmology: Hydrogels as responsive systems for ophthalmic applications

Smart molecules in ophthalmology: Hydrogels as responsive systems for ophthalmic applications

Liposome‐Based Permeable Eyedrops for Effective Posterior Segment Drug Delivery

Blood-Retinal Barrier

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