Ocular Involvement by a Peripheral T-Cell Lymphoma

Saga, T.; Ohno, Shigeaki; Matsuda, Hidehiko; Ogasawara, Minoru; Kikuchi, Kokichi

doi:10.1001/archopht.1984.01040030317027

Cited by 47 publications

(19 citation statements)

References 29 publications

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“…In general, metastases to the eye and ocular adnexa from T-cell lymphomas are uncommon compared to B-cell lymphomas [11, 26-28]. Orbital/ocular adnexal involvement in the nasal type of ENKTCL is usually secondary to invasion from the adjacent nasopharynx [4, 10-13].…”

Section: Discussionmentioning

confidence: 39%

Beneath the Retinal Pigment Epithelium: Histopathologic Findings in Metastatic Extranodal Natural Killer/T-Cell Lymphoma, Nasal Type

McCall

Proia

2018

Ocul Oncol Pathol

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Purpose: To report a case of extranodal natural killer/T-cell lymphoma (ENKTCL), nasal type metastatic to the space beneath the retinal pigment epithelium (RPE) with coincident paraneoplastic lymphoma-associated retinopathy. Methods: Findings of clinical and histopathologic examination are presented with differential diagnoses and a literature review. Case Report: A 53-year-old man presented with bilateral blindness and had exudative retinal detachments overlying subretinal masses in both eyes. Flow cytometry of pericardial fluid revealed malignant T lymphocytes. After two cycles of chemotherapy, the patient was hospitalized and quickly expired. Autopsy revealed lymphoma involving the eyes, heart, right lung, and two subcarinal lymph nodes focally. Histopathologic examination of the eyes revealed intraocular metastases from ENKTCL, nasal type. Expression of CD3 and CD56, along with expression of Epstein-Barr virus by in situ hybridization, confirmed the diagnosis. Lymphomatous infiltrates were confined to the space beneath the neurosensory retina and between the RPE and the Bruch membrane, sparing the uveal tissue, similar to other metastatic T-cell lymphomas. Extensive RPE and photoreceptor loss in regions with and without underlying tumor was typical of a concurrent paraneoplastic lymphoma-associated retinopathy. Conclusion: Patients diagnosed with ENKTCL should be evaluated by an ophthalmologist, as ophthalmic involvement portends a poor prognosis.

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Section: Discussionmentioning

confidence: 39%

Beneath the Retinal Pigment Epithelium: Histopathologic Findings in Metastatic Extranodal Natural Killer/T-Cell Lymphoma, Nasal Type

McCall

Proia

2018

Ocul Oncol Pathol

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“…An aggressive course of primary testicular T-cell lymphoma has been reported by other studies too (2,3,5,6). Despite of aggressive treatment with high-dose chemotherapy and autologous stem cell transplantation as salvage therapy in this patient, the patient experienced a short-term relapse in the leptomeninges.…”

Section: Discussionsupporting

confidence: 45%

Orbital Infiltration as the First Site of Relapse of Primary Testicular T-cell Lymphoma

et al. 2007

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“…The typical fun dus pattern shows a yellowish-white chorioretinal infiltra tion with vitreous opacity [1,2,13,14]. Hypopyon and hy phema are very rare in association with PIL [21,22], Clin ically, PIL presents as a 'masquerade' syndrome and should be differentiated from primary uveitis [12]. Most patients with primary uveitis are treated with corticosteroids.…”

Section: Discussionsupporting

confidence: 42%

Primary Intraocular Lymphoma Mimicking Late Postoperative Endophthalmitis

et al. 1995

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We treated a 65-year old woman with diffuse uveitis and an intraocular mass. The diffuse uveitis resolved with the administration of corticosteroids, but the intraocular mass did not respond to treatment. A transscleral biopsy of the lesion was performed. Histophathological study revealed non-Hodgkin’s large-cell lymphoma. Immunohistochemical analysis showed that the tumor cells were derived from B-cells. The intraocular mass diminished after radiation therapy. The transscleral biopsy proved useful in establishing the correct diagnosis.

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Ocular Involvement by a Peripheral T-Cell Lymphoma

Cited by 47 publications

References 29 publications

Beneath the Retinal Pigment Epithelium: Histopathologic Findings in Metastatic Extranodal Natural Killer/T-Cell Lymphoma, Nasal Type

Beneath the Retinal Pigment Epithelium: Histopathologic Findings in Metastatic Extranodal Natural Killer/T-Cell Lymphoma, Nasal Type

Orbital Infiltration as the First Site of Relapse of Primary Testicular T-cell Lymphoma

Primary Intraocular Lymphoma Mimicking Late Postoperative Endophthalmitis

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