Ocular lubricants: what is the best choice?

Araújo, Daniela Macedo Lins de; Galera, Paula Diniz

doi:10.1590/0103-8478cr20160020

Cited by 6 publications

(11 citation statements)

References 43 publications

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“…A variety of ocular lubricating polymers, such as sodium hyaluronan (hyaluronic acid, HA), methylcellulose, poly(vinyl alcohol) (PVA), polyvinylpyrrolidone (PVP), poly(acrylic acid) (PAAc), have been used in artificial tears [ 70 ]. As a natural polysaccharide found in vitreous and aqueous humor, tears, lacrimal glands, conjunctiva, and corneal epithelium [ 71 ], HA has attracted considerable attraction due to its good biocompatibility and biodegradability.…”

Section: Hydrogel Eye Drops For Dry Eye Treatmentmentioning

confidence: 99%

Recent Advances in Hydrogels for the Diagnosis and Treatment of Dry Eye Disease

Cao

Wang

2022

Gels

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Dry eye disease (DED) is the most common clinical ocular surface disease. Given its multifactorial etiology, no consensus has been reached on the diagnosis criteria for dry eye disease. Topical drug administration remains the mainstay of treatment but is limited to the rapid clearance from the eye surface. To address these problems, hydrogel-based materials were designed to detect biomarkers or act as drug delivery systems by taking advantage of their good biocompatibility, excellent physical and mechanical properties, and long-term implant stability. Biosensors prepared using biocompatible hydrogels can be sensitive in diagnosing DED, and the designed hydrogels can also improve the drug bioavailability and retention time for more effective and long-term treatment. This review summarizes recent advances in the use of hydrogels for diagnosing and treating dry eye, aiming to provide a novel reference for the eventual clinical translation of hydrogels in the context of dry eye disease.

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Section: Hydrogel Eye Drops For Dry Eye Treatmentmentioning

confidence: 99%

Recent Advances in Hydrogels for the Diagnosis and Treatment of Dry Eye Disease

Cao

Wang

2022

Gels

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“…Under the circumstances of the increasing incidence of dry eye disease, especially due to the extensive use of personal computers and other gadget screens, amplified during the Covid-19 pandemic, and associated with global warming and pollution, the use of artificial tears has become crucial for the comfort and maintenance of ocular health (1). The signs and symptoms of dry eye are of concern for ophthalmologists because of their diversity and persistence, sometimes despite adequate treatment (2)(3)(4)(5)(6)(7). The requirement of a good adherence of the patients to treatment is a compulsory condition for success (8).…”

Section: Introductionmentioning

confidence: 99%

Comparative antioxidant activity of various ophthalmic product types for artificial tears under different experimental conditions

et al. 2022

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Artificial tears or lubricants is a developing category in pharmaceutical research, due to the permanent increasing incidence of dry eye syndrome caused by the extensive use of personal computers and other gadget screens, associated with global warming and pollution. Considering the role of inflammation in dry eye syndrome, characterized by the production of free radicals, it is imperative to determine which elements are more significant in forming an artificial tear more effectively and more comfortably for the eye state and for the quality of life. Thus, the aim of the present study was to examine the evolution of the total antioxidant capacity of some frequently commercialized artificial tears via the photochemiluminescence method, using an antioxidant capacity of lipid soluble substances procedure, prior and subsequent to the exposure of these therapy agents to some physical agents. This is a preliminary research aiming to evaluate the impact of various environmental factors on these ophthalmic products, to be continued by evaluating whether the effectiveness of these products, in terms of objective examination and patient preference and adherence criteria, is impacted by the conditions of use and storage. Thus, the total antioxidant capacity of the evaluated artificial tear samples after UVC irradiation at 254 nm wavelength was studied, in order to investigate whether their status suffered any change in terms of antioxidant potential. In addition to the findings obtained in the study, some recommendations were also made.

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Section: Introduction mentioning

confidence: 99%

“…Lacrimomimetics are tear film substitutes that attempt to supplement all parts of the tear film, increasing the volume and stability of this layer, and protecting the ocular surface against desiccation (Araujo and Galera, 2016). Sodium hyaluronate (SH) is a glycosaminoglycan, present in natural tears, with excellent viscoelastic, lubricating and water retention properties (Araujo and Galera, 2016). Carboxymethylcellulose (CMC) is the most commonly used agent in commercial formulations, as it has desirable mucoadhesive and viscoelastic properties and a high retention time on the ocular surface (Araujo and Galera, 2016).…”

Section: Introduction mentioning

confidence: 99%

“…Sodium hyaluronate (SH) is a glycosaminoglycan, present in natural tears, with excellent viscoelastic, lubricating and water retention properties (Araujo and Galera, 2016). Carboxymethylcellulose (CMC) is the most commonly used agent in commercial formulations, as it has desirable mucoadhesive and viscoelastic properties and a high retention time on the ocular surface (Araujo and Galera, 2016).…”

Section: Introduction mentioning

confidence: 99%

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Effect of 0.15% sodium hialuronate and 0.5% carboxymethylcellulose on tear film breakup time in healthy dogs and in dogs with keratoconjunctivitis sicca

Madruga

Ribeiro

Magalhães

et al. 2018

Arq. Bras. Med. Vet. Zootec.

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This study aimed to evaluate the effect of the 0.15% sodium hyaluronate (SH) and of 0.5% carboxymethylcellulose (CMC) on tear film breakup time (TFBUT) in 10 healthy dogs and in 32 eyes of dogs with keratoconjunctivis sicca (KCS). In addition, the goblet cell density (GCD) of this population was quantified. TFBUT was assessed at baseline and at different time points following the instillation of SH and CMC. KCS was graded as mild, moderate, and severe. GCD were quantified from conjunctival biopsies. The number of GCD differed significantly between patients with mild and moderate KCS (P<0.01). TFBUT of healthy dogs increased only for 1 minute after treatment with SH (P<0.01). Regarding baseline and treatments, SH significantly increased TFBUT for up to 30 minutes on the ocular surface, in comparison to CMC, in all categories of KCS (P<0.01). TFBUT and GCD correlated positively when the healthy and diseased eyes were grouped (r=0.41, P=0.006). It can be concluded that in dogs with KCS, SH lasts longer periods on the ocular surface than CMC, but such agents does not increase TFBUT in healthy dogs. Additionally, tear film stability tends to reduce in a linear fashion from the mild to severe form of KCS.

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Ocular lubricants: what is the best choice?

Abstract: ABSTRACT

Cited by 6 publications

References 43 publications

Recent Advances in Hydrogels for the Diagnosis and Treatment of Dry Eye Disease

Recent Advances in Hydrogels for the Diagnosis and Treatment of Dry Eye Disease

Comparative antioxidant activity of various ophthalmic product types for artificial tears under different experimental conditions

Effect of 0.15% sodium hialuronate and 0.5% carboxymethylcellulose on tear film breakup time in healthy dogs and in dogs with keratoconjunctivitis sicca

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