Ocular Mucosal Immunity

O’Sullivan, Nancy L.; Montgomery, P.C.

doi:10.1016/b978-0-12-415847-4.00099-9

Cited by 28 publications

(18 citation statements)

References 286 publications

(354 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…As SARS-CoV-2 first mainly infects the upper respiratory tract (URT), mucosal immune responses are expected to be induced in the nasopharynx, both across the nasal epithelium and via the tonsils and adenoids, which are collectively referred to as nasopharynx-associated lymphoid tissue (NALT) that serve as inductive sites for the mucosal immune system (6,7). It is possible that responses might also be induced through mucosal inductive sites in the lacrimal duct (8) or the oral cavity (9), although the quantitative contribution of such sites to mucosal immune responses in humans is uncertain. Bronchus-associated lymphoid tissue (BALT) is not normally present in adult humans, but can be found in children and adolescents, and may be induced to form by infections (10).…”

Section: The Role Of Mucosal Immune Responsesmentioning

confidence: 99%

Mucosal Immunity in COVID-19: A Neglected but Critical Aspect of SARS-CoV-2 Infection

et al. 2020

View full text Add to dashboard Cite

The mucosal immune system is the largest component of the entire immune system, having evolved to provide protection at the main sites of infectious threat: the mucosae. As SARS-CoV-2 initially infects the upper respiratory tract, its first interactions with the immune system must occur predominantly at the respiratory mucosal surfaces, during both inductive and effector phases of the response. However, almost all studies of the immune response in COVID-19 have focused exclusively on serum antibodies and systemic cell-mediated immunity including innate responses. This article proposes that there is a significant role for mucosal immunity and for secretory as well as circulating IgA antibodies in COVID-19, and that it is important to elucidate this in order to comprehend especially the asymptomatic and mild states of the infection, which appear to account for the majority of cases. Moreover, it is possible that mucosal immunity can be exploited for beneficial diagnostic, therapeutic, or prophylactic purposes.

show abstract

Section: The Role Of Mucosal Immune Responsesmentioning

confidence: 99%

Mucosal Immunity in COVID-19: A Neglected but Critical Aspect of SARS-CoV-2 Infection

et al. 2020

View full text Add to dashboard Cite

show abstract

“…The cornea is located at the anterior aspect of the eye and passes light to the lens. The immune response in the cornea is unreactive compared to that in the conjunctiva, because inflammation of the cornea can affect its transparency 104 . FPR2 is expressed on the corneal endothelium and epithelium, and the functional activity of FPR2 in those regions has been indirectly confirmed by effects of the FPR2 antagonist WRW4 94,95 .…”

Section: Fprs In the Eyementioning

confidence: 99%

Formyl peptide receptors in the mucosal immune system

Jeong

Bae

2020

Exp Mol Med

View full text Add to dashboard Cite

Formyl peptide receptors (FPRs) belong to the G protein-coupled receptor (GPCR) family and are well known as chemotactic receptors and pattern recognition receptors (PRRs) that recognize bacterial and mitochondria-derived formylated peptides. FPRs are also known to detect a wide range of ligands, including host-derived peptides and lipids. FPRs are highly expressed not only in phagocytes such as neutrophils, monocytes, and macrophages but also in nonhematopoietic cells such as epithelial cells and endothelial cells. Mucosal surfaces, including the gastrointestinal tract, the respiratory tract, the oral cavity, the eye, and the reproductive tract, separate the external environment from the host system. In mucosal surfaces, the interaction between the microbiota and host cells needs to be strictly regulated to maintain homeostasis. By sharing the same FPRs, immune cells and epithelial cells may coordinate pathophysiological responses to various stimuli, including microbial molecules derived from the normal flora. Accumulating evidence shows that FPRs play important roles in maintaining mucosal homeostasis. In this review, we summarize the roles of FPRs at mucosal surfaces.

show abstract

“…La producción de la respuesta inmune ocular mediado por Igs se produce luego de una exposición a antígenos que pueden ser a nivel ocular o extraocular (30) . Para que el LGALT logre tener una respuesta inmune mediante IgA se sabe que An Fac med.…”

Section: Sistema Inmunológico Ocularunclassified

“…Para que el LGALT logre tener una respuesta inmune mediante IgA se sabe que An Fac med. 2020;81(2):224-9 esta no puede ser generada por un flujo a contracorriente de antígenos desde la conjuntiva, sino que el estímulo para la migración de linfoblastos puede venir desde el NALT o MALT gastrointestinal, usando la vía linfática del conductor torácico desde los ganglios mesentéricos/ cervicales (30) . El CALT es capaz de captar y procesar antígenos para una adecuada respuesta inmune adaptativa (27) .…”

Section: Sistema Inmunológico Ocularunclassified

“…Los síntomas clínicos se podrían desarrollar de manera secundaria a una disminución ACE-2 local o por activación inicial de citosinas (16,18) . A diferencia de la clínica sistémica de algunos pacientes por la tormenta de citocinas, en el sistema ocular encontramos una serie de procesos que van a regular una actividad inflamatoria autolimitada, la cual estaría brindada por el privilegio inmune, mediado por un aumento de los LTreg así como la secreción de IgA (25,27,29,30) . Figura 3.…”

Section: Conclusión De Respuesta Inmunitaria Ocular Y Covid 19unclassified

See 1 more Smart Citation

COVID-19 y oftalmología: rol del sistema inmunitario

et al. 2020

View full text Add to dashboard Cite

El COVID-19 ocasiona manifestaciones clínicas diversas, las manifestaciones oftalmológicas se presentan como conjuntivitis virales. Luego del ingreso del virus, se producen complejas rutas de respuesta inmunológica. Se hallan receptores para el virus en células de la superficie ocular, con predisposición a infección local. Es probable que luego del ingreso del virus se presente una respuesta limitada de la inflamación ocular, el cual podría estar mediado por el enfoque de privilegio inmune.

show abstract

Ocular Mucosal Immunity

Cited by 28 publications

References 286 publications

Mucosal Immunity in COVID-19: A Neglected but Critical Aspect of SARS-CoV-2 Infection

Mucosal Immunity in COVID-19: A Neglected but Critical Aspect of SARS-CoV-2 Infection

Formyl peptide receptors in the mucosal immune system

COVID-19 y oftalmología: rol del sistema inmunitario

Contact Info

Product

Resources

About