Ocular Rosacea

Akpek, Esen K.; Merchant, Amyna; Pinar, Vakur; Foster, C S

doi:10.1016/s0161-6420(97)30015-3

Cited by 165 publications

(35 citation statements)

References 17 publications

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“…Ocular rosacea 3,137 Some scarring is common Dermatitis herpetiformis 128 Rarely causes scarring Lichen planus 138,139 Rarely causes scarring Systemic lupus and discoid lupus 140 Rarely causes scarring…”

Section: Dermal Diseases With Variable Ocular Involvementmentioning

confidence: 99%

The 2016 Bowman Lecture Conjunctival curses: scarring conjunctivitis 30 years on

Dart

2017

Eye

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This review is in two sections. The first section summarises 35 conditions, both common and infrequent, causing cicatrising conjunctivitis. Guidelines for making a diagnosis are given together with the use of diagnostic tests, including direct and indirect immunofluorescence, and their interpretation. The second section evaluates our knowledge of ocular mucous membrane pemphigoid, which is the commonest cause of cicatrizing conjunctivitis in most developed countries. The clinical characteristics, demographics, and clinical signs of the disease are described. This is followed by a review and re-evaluation of the pathogenesis of conjunctival inflammation in mucous membrane pemphigoid (MMP), resulting in a revised hypothesis of the autoimmune mechanisms causing inflammation in ocular MMP. The relationship between inflammation and scarring in MMP conjunctiva is described. Recent research, describing the role of aldehyde dehydrogenase (ALDH) and retinoic acid (RA) in both the initiation and perpetuation of profibrotic activity in MMP conjunctival fibroblasts is summarised and the potential for antifibrotic therapy, using ALDH inhibition, is discussed. The importance of the management of the ocular surface in MMP is briefly summarised. This is followed with the rationale for the use of systemic immunomodulatory therapy, currently the standard of care for patients with active ocular MMP. The evidence for the use of these drugs is summarised and guidelines given for their use. Finally, the areas for research and innovation in the next decade are reviewed including the need for better diagnostics, markers of disease activity, and the potential for biological and topical therapies for both inflammation and scarring.

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Section: Dermal Diseases With Variable Ocular Involvementmentioning

confidence: 99%

The 2016 Bowman Lecture Conjunctival curses: scarring conjunctivitis 30 years on

Dart

2017

Eye

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“…In one report, 81% of patients presented with lid margin telangiectasia, 78% with meibomian gland dysfunction, and 65% with blepharitis [12]. …”

Section: Discussionmentioning

confidence: 99%

“…In one study, 33% of patients with ocular rosacea had corneal involvement [10]. The most common presentation was punctate epithelial erosions occurring in 13.6% [12, 14]. Wise reported that 67% of patients presenting with corneal complaints to the ophthalmology clinic had corneal neovessels and infiltrates [15].…”

Section: Discussionmentioning

confidence: 99%

“…Additionally, tetracycline in subantimicrobial levels has been proven to be effective in rosacea for many decades [26–28]. In particular, doxycycline and its derivatives were found to improve ocular signs and symptoms of rosacea [12, 29–35]. In fact, doxycycline 100 mg daily has been shown to improve ocular disease and increase the tear break-up time [36].…”

Section: Discussionmentioning

confidence: 99%

“…They range from mild blepharoconjunctivitis with injection, tearing, and burning sensation to sight-threatening corneal neovascularization, scarring, thinning, and perforation [12]. …”

Section: Rosaceamentioning

confidence: 99%

See 2 more Smart Citations

Ocular Rosacea Causing Corneal Melt in an African American Patient and a Hispanic Patient

Saade

Abiad

Jan

et al. 2017

Case Reports in Ophthalmological Medicine

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Purpose To discuss two rare presentations of ocular rosacea in a Hispanic patient and an African American patient with unusual ocular manifestations. Case Report Case 1: a 43-year-old Hispanic woman presented with right eye corneal perforation. Her prior medical history was significant for rosacea only, diagnosed clinically by a dermatologist. Her eye exam showed signs of bilateral ocular rosacea. An emergent full thickness tectonic corneal patch graft was done. The patient's bilateral eye symptoms improved one month after initiating rosacea treatment. Case 2: a 51-year-old African American man with long standing history of untreated rosacea presented with bilateral peripheral corneal thinning with neovascularization that led to right eye corneal perforation. Glue and bandage contact lens were applied. The patient did well 4 weeks after starting antibacterial, oral steroids, and rosacea treatment. Discussion Ocular rosacea can present in Hispanic and African American patients with severe manifestations such as corneal perforation.

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Rosacea, Perioral Dermatitis and Similar Dermatoses, Flushing and Flushing Syndromes

Berth-Jones¹

2004

Rook's Textbook of Dermatology

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Ocular Rosacea

Cited by 165 publications

References 17 publications

The 2016 Bowman Lecture Conjunctival curses: scarring conjunctivitis 30 years on

The 2016 Bowman Lecture Conjunctival curses: scarring conjunctivitis 30 years on

Ocular Rosacea Causing Corneal Melt in an African American Patient and a Hispanic Patient

Rosacea, Perioral Dermatitis and Similar Dermatoses, Flushing and Flushing Syndromes

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