Ocular Rosacea

Jenkins, Mark S.; Brown, Stuart I.; Lempert, Steven L.; Weinberg, Richard J.

doi:10.1016/0002-9394(79)90525-7

Cited by 87 publications

(54 citation statements)

References 7 publications

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“…Recurrent corneal epithelial erosions have been reported in patients with ocular rosacea (67,74,75) . Other uncommon corneal findings include pseudodendritic ulcer and pseudokeratoconus, presenting with inferior corneal thinning and high astigmatism (76)(77)(78) .…”

Section: Corneamentioning

confidence: 99%

Ocular rosacea: a review

Vieira¹,

Höfling-Lima²,

Mannis³

2012

Arq. Bras. Oftalmol.

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Section: Corneamentioning

confidence: 99%

Ocular rosacea: a review

Vieira¹,

Höfling-Lima²,

Mannis³

2012

Arq. Bras. Oftalmol.

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“…5 Table 1 lists other causes conditions associated with RCE. 2,[6][7][8][9] The conditions that are associated with RCE can be classified as either primary or secondary depending on whether the BM complex abnormality is intrinsic or acquired (Table 1). Primary types tend to be bilateral, symmetrical and develop into multiple corneal locations.…”

Section: Aetiologymentioning

confidence: 99%

Pathogenesis, clinical features and management of recurrent corneal erosions

Ramamurthi

Rahman

Dutton

et al. 2005

Eye

113

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Recurrent corneal erosions (RCE) are common. They are characterised by repeated episodes of pain, difficulty in opening the eyes, watering, and photophobia resulting from poor epithelial adhesion. In the majority of patients with RCE, trauma is the initiating factor. Epithelial, stromal, and endothelial corneal dystrophies have all been described in association with RCE. Other causes that may lead to RCE include chemical and thermal injuries, previous herpetic keratitis, meibomian gland dysfunction, ocular rosacea, diabetes mellitus, Salzmann's nodular degeneration, band keratopathy, previous bacterial ulceration, kerato-conjunctivitis sicca, and epidermolysis bullosa. The conditions that are associated with RCE can be either primary or secondary depending on whether the basement membrane complex abnormality is intrinsic or acquired. Primary types tend to be bilateral, symmetrical and develop in multiple corneal locations. The pathogenetic mechanism of this disorder is related to poor adhesion of the corneal epithelium to the underlying stroma. Excessive matrix metalloproteinase (MMP) activity may play a role in the pathogenesis. Although the majority of patients will respond to simple measures such as padding and antibiotic ointment, RCE resistant to simple measures require approaches that are more elaborate. The common goal of these approaches is to encourage proper formation of adhesion complexes between the epithelium and the stroma. The use of longterm contact lenses, autologous serum eye drops, botulinum toxin, induced ptosis, oral MMP inhibitors, diamond burr polishing of Bowman's membrane have been reported with varying degree of success in treating RCE. Anterior stromal puncture with insulin needles or Neodymium : aluminium-yttriumgarnet may enhance the epithelial adhesion to the basement membrane by scar formation and success rates of up to 80% have been reported in the treatment of recalcitrant RCE. Excimer laser photo-therapeutic keratectomy (PTK) is now a well-established treatment modality for RCE and is being used both safely and effectively. Partial ablation of Bowman's layer with PTK gives a smooth surface for the newly generating epithelium to migrate and form adhesion complexes. The pathogenesis, clinical features, and management options of this common disorder are discussed in this review article.

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“…According to Jenkins et al 6 it is characterised by bulbar and palpebral conjunctival hyperaemia, telangiectasia of the lid margins, chalazia, and blepharitis. There are also punctate epithelial erosions, usually in the inferior half of the cornea, and there may be dystrophic epithelial signs.…”

Section: Differential Diagnosismentioning

confidence: 99%

The questionably dry eye.

Mackie¹,

Seal²

1981

British Journal of Ophthalmology

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From 1Moorfields Eye Hospital, City Road, London EC], and the 2Public Health Laboratory, General Hospital, Tremona Road, Southampton S09 4XY SUMMARY This paper is concerned with the recognition of the dry eye when the clinical diagnosis is in doubt and other external eye diseases may be present. Papillary conjunctivitis is common to the dry eye as well as other pathological conditions and confuses the diagnosis. We have correlated the factors involved in the assessment for dryness. We have shown that particulate matter in the unstained tear film is associated with low tear lysozyme concentration. Tear flow and tear lysozyme are not necessarily interrelated, but a low lysozyme concentration (tear lysozyme ratio <1 0) is associated with keratoconjunctivitis sicca. The Schirmer I test can produce false positive results, and we have suggested a modification to overcome this. This modified test will detect the eye with severely depleted lysozyme secretion, but it is unreliable for detecting the eye with moderately depleted secretion. We find that its lowest normal limit should be considered as 6 mm.

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Ocular Rosacea

Cited by 87 publications

References 7 publications

Ocular rosacea: a review

Ocular rosacea: a review

Pathogenesis, clinical features and management of recurrent corneal erosions

The questionably dry eye.

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