Ocular surface squamous neoplasia in a renal transplant recipient on immunosuppressive therapy

Shome, Debraj; Honavar, Santosh G; Manderwad, Guru Prasad; Vemuganti, Geeta K.

doi:10.1038/sj.eye.6702270

Cited by 9 publications

(8 citation statements)

References 6 publications

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“…To date, most published studies of the association between HIV seropositivity and OSSN have taken place in Africa, Asia and North America (USA). Other potential risk factors or associations include human papilloma virus (HPV) infection; [17,24,26] sunlight exposure [23,24,27], which can lead to mutations in the tumour suppressor gene p53; [28] p63, a homologue of p53; [29,30] smoking; [24,31] immunosuppression; [32][33][34] and xeroderma pigmentosa [35,36]. There have also been suggestions of a possible association between OSSN and atopic keratoconjunctivitis [23,32,[37][38][39].…”

Section: Introductionmentioning

confidence: 99%

A prospective study of the incidence, associations and outcomes of ocular surface squamous neoplasia in the United Kingdom

Kiire

Stewart

Srinivasan

et al. 2018

Eye

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Section: Introductionmentioning

confidence: 99%

A prospective study of the incidence, associations and outcomes of ocular surface squamous neoplasia in the United Kingdom

Kiire

Stewart

Srinivasan

et al. 2018

Eye

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“…1 However, the present case is the first isolated OSSN without skin carcinoma in KT recipients after long-term tacrolimus treatment. [1][2][3]6 In this male patient, there is no skin cancer after three years follow-up. OSSN, which is considered to be a low-grade malignancy, usually tends to recur within 2 years.…”

Section: Discussionmentioning

confidence: 61%

“…The development of OSSN after KT is rare. [1][2][3] The major causative factor for OSSN is exposure to solar ultraviolet radiation. 1 The increased risk of OSSN in our case was likely related to the immunosuppressive drugs he was taking and to ultraviolet radiation.…”

Section: Discussionmentioning

confidence: 99%

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Isolated Ocular Surface Squamous Neoplasia in a Renal Transplant Recipient

Aktaş¹,

Yazıcı²,

Kilic³

et al. 2012

Exp Clin Transplant

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Ocular surface squamous neoplasia is a rare complication after a kidney transplant, related with increased risk and poor prognosis. Generally, ocular surface squamous neoplasia in kidney transplant patients is associated with skin lesions. We report a case of ocular surface squamous neoplasia without skin lesions in a kidney transplant recipient. Systematic periodic ophthalmic evaluation of recipients may help ensure the early diagnosis of subtle ocular surface squamous neoplasia.

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“…Additional risks have also been reported in immunosuppressed cancer patients and organ transplant patients. (Shelil et al 2003;Shome et al 2006) As well, there have been reports of OSSN after corneal grafts, which may partly be related to local immunosuppression, HPV, or possibly that neoplastic cells had been in the donor corneal epithelia at the time of transplantation. (Ramasubramanian et al 2010) …”

Section: Immunosuppressionmentioning

confidence: 99%