Odontoblast-like MDPC-23 cells function as odontoclasts with RANKL/M-CSF induction

Duan, Xiaohong; Yang, Ting; Wen, Xuan; Xue, Yan; Zhou, Mi

doi:10.1016/j.archoralbio.2012.05.014

Cited by 14 publications

(20 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…One study found that MDPC‐23 cells could generate TRAP‐positive multinucleated cells able to resorb dentine following induction by RANKL/M‐CSF (Duan et al . ). Thus, the present study induced MDPC‐23 cells with LPS to observe the influence of this treatment on odontoclastogenesis.…”

Section: Discussionmentioning

confidence: 97%

“…A recent study confirmed that RANKL/M‐CSF might induce odontoblast‐like MDPC‐23 cells to generate odontoclast‐like cells or to function as odontoclasts (Duan et al . ). Thus, the MDPC‐23 cell line can be regarded as a good cell model to study the possibility of generating odontoclasts directly from dental pulp/papilla cells.…”

Section: Introductionmentioning

confidence: 97%

“…Dental papilla cells derived from the ectomesenchyme are precursor cells with strong proliferation and differentiation abilities; they can further form odontoblasts or be mineralized into dentine (Tziafas & Kodonas 2010). A recent study confirmed that RANKL/M-CSF might induce odontoblast-like MDPC-23 cells to generate odontoclast-like cells or to function as odontoclasts (Duan et al 2013). Thus, the MDPC-23 cell line can be regarded as a good cell model to study the possibility of generating odontoclasts directly from dental pulp/papilla cells.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Odontoclastogenesis of mouse papilla‐derived MDPC‐23 cells induced by lipopolysaccharide

Jiang

2017

Int Endodontic J

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Odontoclastogenesis of mouse papilla‐derived MDPC‐23 cells induced by lipopolysaccharide

Jiang

2017

Int Endodontic J

View full text Add to dashboard Cite

show abstract

“…The authors suggested that RANKL is directly involved in inducing odontoblast-like cells to differentiate into odontoclast-like cells or to function as odontoclasts. [38] Other predisposing genetic markers have been found in the vitamin D receptor gene. [39] These variants have been associated with homeostatic imbalances of bone that could affect the pathological process of root resorption.…”

Section: Genetic Influence In Earr and Its Biological Scenariomentioning

confidence: 99%

Bone Density and Dental External Apical Root Resorption

Iglesias-Linares

Morford

Hartsfield

2016

Curr Osteoporos Rep

View full text Add to dashboard Cite

When orthodontic patients desire shorter treatment times with aesthetic results and long-term stability, it is important for the orthodontist to understand the potential limitations and problems that may arise during standard and/or technology-assisted accelerated treatment. Bone density plays an important role in facilitating orthodontic tooth movement (OTM), such that reductions in bone density can significantly increase movement velocity. Lifestyle, genetic background, environmental factors and disease status all can influence a patients’ overall health and bone density. In some individuals, these factors may create specific conditions that influence systemic-wide bone metabolism. Both genetic variation and the onset of a bone-related disease can influence systemic bone density and local bone density, such as is observed in the mandible and maxilla. These types of localized density changes can affect the rate of OTM and may also influence the risk of unwanted outcomes, i.e., the occurrence of dental external apical root resorption (EARR).

show abstract

“…No processo de erupção dental, que requer reabsorção do osso alveolar e da raiz do dente decíduo correspondente, os osteoclastos e odontoclastos participam como células ativas e responsáveis pelas reabsorções óssea e radicular, respectivamente 7,8 . Enquanto os osteoclastos são células amplas multinucleadas, derivadas da fusão de células de origem hematopoiética, da linhagem mielóide 9,10 , os odontoclastos apresentam-se como células similares 11,12 , de mesma origem, porém menores 12 , embora não esteja esclarecido se somente células hematopoiéticas e monócitos do sangue sejam os únicos precursores dos odontoclastos 13 . Mas ambos tipos celulares, osteoclastos e odontoclastos, são necessários para erupção e consequente irrupção dos dentes permanentes 14 , sendo que a reabsorção radicular decídua é regulada de forma similar à remodelação óssea 1,15 .…”

Section: Mecanismos Envolvidos Na Erupção Dentalunclassified

Retenção prolongada de dentes decíduos: possíveis fatores etiológicos locais e sistêmicos

Xavier¹

View full text Add to dashboard Cite

Root resorption is a physiological event for primary teeth. However, there are cases where these teeth are maintained beyond the normal exfoliation time, even when the corresponding permanent teeth is present. Since there are few data concerning the real cause of prolonged retention of primary teeth, the exact reasons must be investigated. The aim of this study was to assess if local factors like RANKL, RANK, OPG, MCP-1, RUNX2, or systemic factors such as vitamin D, PTH and IGF-I could to be involve in the bone and root biology, in cases of persistent primary teeth, with the corresponding permanent teeth in situ. Patients with persistent primary teeth (n=14, group R) and patients without persistent primary teeth (n=14, group C), but with orthodontic indication of tooth extraction, were selected. After the teeth extractions, remaining periodontal ligament around the roots and blood samples were collected and assessed by qPCR and chemiluminescence, respectively. The present study found significant lower level of RANKL in the group R compared to group C (p=0,023). Although it was not significantly different, the level of RANK was also reduced in group R compared to group C. The expression of others local factors was similar between group R and C. Concernig systemic factors, the serum level of vitamin D were reduced in the group R compared to group C (p=0,0572) although it was not statistically significant. There were no significant differences between both groups for the others systemic studied factors. It is possible that a lower RANKL and RANK expression is involved in prolonged retention of primary teeth and our data also suggest that low serum levels of vitamin D could also be involved in the etiology of the retention.

show abstract

Odontoblast-like MDPC-23 cells function as odontoclasts with RANKL/M-CSF induction

Cited by 14 publications

References 25 publications

Odontoclastogenesis of mouse papilla‐derived MDPC‐23 cells induced by lipopolysaccharide

Odontoclastogenesis of mouse papilla‐derived MDPC‐23 cells induced by lipopolysaccharide

Bone Density and Dental External Apical Root Resorption

Retenção prolongada de dentes decíduos: possíveis fatores etiológicos locais e sistêmicos

Contact Info

Product

Resources

About