OECD Series on Testing and Assessment

doi:10.1787/20777876

Cited by 21 publications

(15 citation statements)

References 40 publications

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“…Knowledge from clinical research on neurodevelopmental disorders with genetic alterations as basis for disease are also helpful in determining human-relevant, cell-based endpoints. Here, for example, diverse receptor tyrosine kinase (RTK) mutations, leading to activation of protein kinase B (AKT, PKB), can cause for skin sensitization (OECD 2016b;Delrue et al, 2016;Adeleye et al, 2015;Urbisch et al, 2015). Transferring this concept to DNT, where currently only a few relevant AOPs are available, and where many more pathways might underlie toxicity for the developing brain (Bal-Price et al, 2015b, 2017Bal-Price and Meek, 2017), a similar procedure is not yet feasible.…”

Section: Making Alternative Methodologies For Dnt Testing Acceptable For Regulatory Purposesmentioning

confidence: 99%

“…The US EPA Office of Pesticide Programs recommends following this guidance to describe non-guideline in vitro methods for acute toxicity (EPA, 2016). According to this guidance (OECD, 2014b), the method description should include purpose and scope of the assay, method components including protocol and reference chemicals, the stage of development of the assay, the quality/acceptance criteria, data interpretation and prediction model(s), and performance metrics including sensitivity and predictivity (i.e., proportion of false negatives for positive controls, and of false positives for negative controls).…”

Section: Making Alternative Methodologies For Dnt Testing Acceptable For Regulatory Purposesmentioning

confidence: 99%

See 1 more Smart Citation

Recommendation on test readiness criteria for new approach methods in toxicology: Exemplified for developmental neurotoxicity

Bal‐Price

Högberg

Crofton

et al. 2018

ALTEX

139

117

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Multiple non-animal-based test methods have never been formally validated. In order to use such new approach methods (NAMs) in a regulatory context, criteria to define their readiness are necessary. The field of developmental neurotoxicity (DNT) testing is used to exemplify the application of readiness criteria. The costs and number of untested chemicals are overwhelming for in vivo DNT testing. Thus, there is a need for inexpensive, high-throughput NAMs to obtain initial information on potential hazards, and to allow prioritization for further testing. A background on the regulatory and scientific status of DNT testing is provided showing different types of test readiness levels, depending on the intended use of data from NAMs. Readiness criteria, compiled during a stakeholder workshop that united scientists from academia, industry and regulatory authorities, are presented. An important step beyond the listing of criteria was the suggestion of a preliminary scoring scheme. On this basis a (semi)-quantitative analysis process was assembled on test readiness of 17 NAMs with respect to various uses (e.g., prioritization/screening, risk assessment). The scoring results suggest that several assays are currently at high readiness levels. Therefore, suggestions are made on how DNT NAMs may be assembled into an integrated approach to testing and assessment (IATA). In parallel, the testing state in these assays was compiled for more than 1000 compounds. Finally, a vision is presented on how further NAM development may be guided by knowledge of signaling pathways necessary for brain development, DNT pathophysiology, and relevant adverse outcome pathways (AOP).

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Section: Making Alternative Methodologies For Dnt Testing Acceptable For Regulatory Purposesmentioning

confidence: 99%

Section: Making Alternative Methodologies For Dnt Testing Acceptable For Regulatory Purposesmentioning

confidence: 99%

Recommendation on test readiness criteria for new approach methods in toxicology: Exemplified for developmental neurotoxicity

Bal‐Price

Högberg

Crofton

et al. 2018

ALTEX

139

117

View full text Add to dashboard Cite

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“…There are no approved OECD or EPA guideline study protocols for measurement of TPO inhibition.. However, there is an OECD scoping document on identification of chemicals that modulate TH signaling that provides details on a TPO assay (OECD, 2017).…”

Section: How It Is Measured or Detectedmentioning

confidence: 99%

Adverse Outcome Pathway on inhibition of Thyroperoxidase and subsequent adverse neurodevelopmental outcomes in mammals

Crofton¹,

Gilbert²,

Friedman³

et al. 2019

OECD Series on Adverse Outcome Pathways

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This Adverse Outcome Pathway (AOP) on Inhibition of Thyroperoxidase and Subsequent Adverse Neurodevelopmental Outcomes in Mammals, has been developed under the auspices of the OECD AOP Development Programme, overseen by the Extended Advisory Group on Molecular Screening and Toxicogenomics (EAGMST), which is an advisory group under the Working Group of the National Coordinators for the Test Guidelines Programme (WNT). The AOP has been reviewed internally by the EAGMST, externally by experts nominated by the WNT, and has been endorsed by the WNT and the Working Party on Hazard Assessment (WPHA) in May 2019. Through endorsement of this AOP, the WNT and the WPHA express confidence in the scientific review process that the AOP has undergone and accept the recommendation of the EAGMST that the AOP be disseminated publicly. Endorsement does not necessarily indicate that the AOP is now considered a tool for direct regulatory application. The Joint Meeting of the Chemicals Committee and the Working Party on Chemicals, Pesticides and Biotechnology agreed to declassification of this AOP on 26 June 2019. This document is being published under the responsibility of the Joint Meeting of the Chemicals Committee and the Working Party on Chemicals, Pesticides and Biotechnology. The outcome of the internal and external reviews are publicly available respectively in the AOP Wiki and the eAOP Portal of the AOP Knowledge Base at the following links: [internal review] [external review].

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“…Therefore, the problem of defining the AD of a model is closely related to the problem of assessing the reliability of its predictions. According to the Organization of Economic Co-operation and Development (OECD) principles, QSAR/QSPR models should have "defined an applicability domain" [7].…”

Section: Introductionmentioning

confidence: 99%

Comprehensive Analysis of Applicability Domains of QSPR Models for Chemical Reactions

Rakhimbekova

Madzhidov

Nugmanov

et al. 2020

IJMS

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Nowadays, the problem of the model’s applicability domain (AD) definition is an active research topic in chemoinformatics. Although many various AD definitions for the models predicting properties of molecules (Quantitative Structure-Activity/Property Relationship (QSAR/QSPR) models) were described in the literature, no one for chemical reactions (Quantitative Reaction-Property Relationships (QRPR)) has been reported to date. The point is that a chemical reaction is a much more complex object than an individual molecule, and its yield, thermodynamic and kinetic characteristics depend not only on the structures of reactants and products but also on experimental conditions. The QRPR models’ performance largely depends on the way that chemical transformation is encoded. In this study, various AD definition methods extensively used in QSAR/QSPR studies of individual molecules, as well as several novel approaches suggested in this work for reactions, were benchmarked on several reaction datasets. The ability to exclude wrong reaction types, increase coverage, improve the model performance and detect Y-outliers were tested. As a result, several “best” AD definitions for the QRPR models predicting reaction characteristics have been revealed and tested on a previously published external dataset with a clear AD definition problem.

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OECD Series on Testing and Assessment

Cited by 21 publications

References 40 publications

Recommendation on test readiness criteria for new approach methods in toxicology: Exemplified for developmental neurotoxicity

Recommendation on test readiness criteria for new approach methods in toxicology: Exemplified for developmental neurotoxicity

Adverse Outcome Pathway on inhibition of Thyroperoxidase and subsequent adverse neurodevelopmental outcomes in mammals

Comprehensive Analysis of Applicability Domains of QSPR Models for Chemical Reactions

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