Oesophageal mucosal intercellular space diameter and reflux pattern in childhood erosive and non-erosive reflux disease

Mancini, Valentina; Ribolsi, Mentore; Gentile, Massimo; de’Angelis, G.L.; Bizzarri, Barbara; Lindley, Keith; Cucchiara, Salvatore; Cicala, Michele; Borrelli, Osvaldo

doi:10.1016/j.dld.2012.08.001

Cited by 15 publications

(16 citation statements)

References 30 publications

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“…In contrast to the ex vivo findings, in vivo mucosal impedance values in that and many other studies showed a remarkable downward gradient from healthy controls to NERD to EE [21,22,26,27,28]. This discrepancy between in vivo and ex vivo measurements in NERD patients may be explained by the possible influence of inflammatory mediators released from sensory nerve endings (SP and CGRP) and resident immune cells in the lamina propria of the mucosa [29,30].…”

Section: Discussioncontrasting

confidence: 69%

Exploration of the Esophageal Mucosal Barrier in Non-Erosive Reflux Disease

Rinsma

Farré

Troost

et al. 2017

IJMS

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In the absence of visible mucosal damage, it is hypothesized that the esophageal mucosal barrier is functionally impaired in patients with non-erosive reflux disease (NERD). The aim of the present study was to perform an exploratory analysis of the mucosal barrier in NERD compared to erosive esophagitis (EE) and controls. A second aim was to explore TRPV1 gene transcription in relation to the mucosal barrier function and heartburn symptoms. In this prospective study, 10 NERD patients, 11 patients with active erosive esophagitis and 10 healthy volunteers were included. Biopsies from non-eroded mucosa were obtained for (1) ex vivo analyses (Ussing chamber) of transepithelial electrical resistance (TEER) and permeability (2) gene transcription of tight-junction proteins and transient receptor potential vanilloid subfamily member 1 (TRPV1). No differences in TEER or permeability were found between NERD and healthy volunteers, whereas TEER was lower in patients with erosive esophagitis. TRPV1 gene transcription was not significantly different between EE, NERD and controls. Conclusions: esophageal mucosal barrier function and TRPV1 transcription is not significantly altered in NERD patients. Future research is needed to explore other potential mechanisms that may account for the high symptom burden in these patients.

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Section: Discussioncontrasting

confidence: 69%

Exploration of the Esophageal Mucosal Barrier in Non-Erosive Reflux Disease

Rinsma

Farré

Troost

et al. 2017

IJMS

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“…Last, another study looking at mean intercellular space diameter values (biopsies taken at 2–3 cm above the Z‐line) found significant higher values in both children with erosive and non‐erosive reflux disease when compared to controls, but not between children with erosive and non‐erosive reflux disease. Additionally, no correlation was found between any reflux parameter and intracellular space diameter values …”

Section: Ph‐impedance As a Diagnostic Tool For Esophagitismentioning

confidence: 86%

Reflux monitoring in children

Singendonk

Benninga

Wijk

2016

Neurogastroenterology Motil

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Recently, multichannel intraluminal impedance (MII) monitoring was added to the repertoire of tests to evaluate the (patho)physiology of gastroesophageal reflux (GER) in children. Its advantage above the sole monitoring of the esophageal pH lies in the ability of the detection of both acid and nonacid GER and to discern between liquid and gas GER. Currently, combined 24 h pH-MII monitoring is recommended for evaluation of gastro-esophageal reflux disease (GERD) and its relation to symptoms in infants and children, despite the lack of reference values in these age groups. There is new evidence in the current issue of this Journal supporting the role of pH-MII monitoring for the evaluation of children presenting with gastrointestinal symptoms suggestive of GERD and the prediction of the presence of reflux esophagitis. However, several issues should be taken into account when performing pH-MII clinically.

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“…Unfortunately, large well-designed studies evaluating upper endoscopy and esophageal pH impedance findings in children with dyspepsia and GERD symptoms are lacking. Mancini et al reported increased EEIC space in children with NERD, but the increase in EEIC space was similar in subjects with or without increased distal esophageal acid exposure (24). Mancini et al reported increased EEIC space in children with NERD, but the increase in EEIC space was similar in subjects with or without increased distal esophageal acid exposure (24).…”

Section: Discussionmentioning

confidence: 99%