Oestrogen receptor β expression and depth of myometrial invasion in human endometrial cancer

Takama, Fumiko; Kanuma, Tatsuya; Wang, D; Kagami, Issei; Mizunuma, Hideki

doi:10.1054/bjoc.2000.1589

Cited by 27 publications

(12 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Overall, the inconsistencies observed with MI may be due to differences in stage or grade amongst selected patients and the various definitions of MI; depths of >1/3 (26), >50% (22) and ≥66% (18) are all regarded as cut-off values for deep MI in various studies, indicating that in endometrial cancer, the depth of MI has various roles according to the severity of the disease. In previous studies MI has been associated with certain biochemical indicators, including levels of free insulin-like growth factor-1 plasma (27), nucleoporin (88kDa)-mRNA expression (28) and endoplasmic reticulum-β (29). An association was also demonstrated between tumor-associated macrophages and depth of MI (30).…”

Section: A B Cmentioning

confidence: 87%

Analysis of recurrence and survival rates in grade 3 endometrioid endometrial carcinoma

Wang

Nan

et al. 2016

Oncology Letters

View full text Add to dashboard Cite

Abstract. The aim of the present study was to determine risk factors associated with recurrence and survival in patients with grade 3 endometrioid endometrial carcinoma (G3EEC). A retrospective analysis of 117 patients with G3EEC, who were admitted to the Obstetrics and Gynecology Hospital of Fudan University between January 2000 and December 2011, was performed. The χ 2 test or Fisher's exact test were used for the comparison of categorical variables. Kaplan-Meier method was used for estimating recurrence-free survival (RFS), disease-specific survival (DSS) and overall survival (OS) rates. Univariate and multivariate Cox proportional hazards model were used to assess the prognostic significance of various patient characteristics. In 117 patients, 16 patients (13.7%) had tumor recurrence, of which 6 (37.5%) developed local-regional recurrence and 10 (62.5%) developed distant recurrence. Out of the 16 patients with tumor recurrence, 14 (87.5%) had a recurrence within 3 years of surgery. Statistically significant characteristics affecting RFS, DSS and OS rates were outer half myometrial invasion (MI ≥50%), advanced International Federation of Gynecology and Obstetrics stage, positive lymph node metastasis (PLNM), lymph vascular space invasion, adnexal involvement and characterization as a high-risk group, according to the Gynecologic Oncology Group 99 stratification algorithm. RFS was associated with the depth of cervical mucosa (stromal) involvement. Furthermore, in the multivariate Cox proportional hazards model, significant independent adverse factors for RFS and DSS included MI ≥50% and adnexal involvement. For OS, there were no statistically significant prognostic factors. In conclusion, MI ≥50% and adnexal involvement are independent prognostic factors for RFS and DSS in G3EEC patients.

show abstract

Section: A B Cmentioning

confidence: 87%

Analysis of recurrence and survival rates in grade 3 endometrioid endometrial carcinoma

Wang

Nan

et al. 2016

Oncology Letters

View full text Add to dashboard Cite

show abstract

“…Interestingly, the ER-ß/ER-· mRNA ratio was high in advanced invasive carcinoma. Additionally, Western blot analysis demonstrated that ER-ß was highly expressed in comparison with ER-· in endometrial cancer with severe myometrial invasion, suggesting that ER-ß is important in the progression of myometrial invasion (19).…”

Section: Discussionmentioning

confidence: 97%

“…The loss of ER-ß expression in cancer cells might be a characteristic step in tumor cell dedifferentiation (13). Moreover, an imbalance in the ER-· and ER-ß expression might be of substantial importance in estrogendependent carcinogenesis (13,14,(18)(19)(20).…”

Section: Introductionmentioning

confidence: 99%

Prognostic significance and clinical importance of estrogen receptor α and β in human endometrioid adenocarcinomas

Mylonas¹

2010

Oncol Rep

View full text Add to dashboard Cite

Abstract. Human endometrial cancer expresses both the known estrogen receptors (ER-· and ER-ß). The significance of the relative expression of both ER subtypes in endometrial adenocarcinomas remains to be clarified and the usefulness of the determination of the receptor status in endometrial cancer patients is still controversially discussed. Therefore, the aims of this study were the evaluation of the expression patterns of ER-· and ER-ß with the characterization of the prognostic significance in uterine endometrioid adenocarcinomas. Pathological and surgical records of 214 patients who were diagnosed with an endometrioid adenocarcinoma without other histological types (including mucinous, mixed, squamous or villoglandular differentiation) were reviewed for both estrogen receptors. The expression of both estrogen receptors was demonstrated in malignant endometrioid adenocarcinomas. ER-· was associated with histological differentiation, while ER-ß demonstrated an association with ovarial invasion. The loss of receptor positivity for ER-· resulted in a poorer causespecific survival in endometrial cancer patients, while ER-ß did not affect survival. Interestingly, metastatic patients who expressed ER-· or ER-ß had a better survival outcome than estrogen receptor negative patients. Moreover, when tumor samples of affected patients expressed ER-·, they had a better cause-specific survival compared to negative findings regarding both estrogen receptors. However, ER-· and ER-ß were not independent factors with survival in endometrial adenocarcinoma patients. Therefore, the analysis of both estrogen receptors might be used as a marker to identify highrisk patients only in a subset of patients with endometrioid adenocarcinoma.

show abstract

“…A decreased ERα/ERβ ratio has been found to be associated with ovarian invasion in a large study comprising 214 endometrial carcinoma samples [65]. Low ERα/ERβ ratios have also been suggested to lead to progression of myometrial invasion [57,64,66]. Another study of 315 endometrial adenocarcinoma patients showed a decreased ERα/ERβ ratio to be associated with shorter DFS and OS [63].…”

Section: Erβ In Endometrial Cancermentioning

confidence: 99%

Role of estrogen receptor β in gynecological cancer

Haring

Schüler

Lattrich

et al. 2012

Gynecologic Oncology

View full text Add to dashboard Cite

Oestrogen receptor β expression and depth of myometrial invasion in human endometrial cancer

Cited by 27 publications

References 18 publications

Analysis of recurrence and survival rates in grade 3 endometrioid endometrial carcinoma

Analysis of recurrence and survival rates in grade 3 endometrioid endometrial carcinoma

Prognostic significance and clinical importance of estrogen receptor α and β in human endometrioid adenocarcinomas

Role of estrogen receptor β in gynecological cancer

Contact Info

Product

Resources

About