Off-pump bypass graft operation significantly reduces oxidative stress and inflammation

Matata, Bashir M.; Sosnowski, Andrzej; Galiñanes, Manuel

doi:10.1016/s0003-4975(99)01420-4

Cited by 260 publications

(163 citation statements)

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“…9 It is known that pre-operative mild kidney impairment is an independent predictor of long-term postoperative risk of death. [10][11][12] It is estimated that up to 20% of patients undergoing cardiac surgery have pre-existing renal insufficiency, typically with a creatinine value of > 132 µmol/l. 13 An increasing body of evidence suggests that inflammatory factors and oxidant stress play significant roles in the pathogenesis of coronary artery disease in patients with underlying end-stage kidney disease.…”

Section: Introductionmentioning

confidence: 99%

“…It has been suggested that oxidative stress induced by cardiac surgery is involved in the pathogenesis of an underlying systemic inflammatory response (SIRS) experienced by most patient's perioperatively [9,10]. This leads to a further reduction in antioxidant capacity and an increased onset of a cascade of events such as protein modification, lipid peroxidation, and the activation of circulating blood leukocytes.…”

Section: Introductionmentioning

confidence: 99%

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The impact of continuous haemofiltration with high-volume fluid exchange during cardiopulmonary bypass surgery on the recovery of patients with impaired renal function: a pilot randomised trial

Matata

Mediratta²,

Morgan³

et al. 2013

Health Technology Assessment

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Health Technology Assessment is indexed in MEDLINE, CINAHL, EMBASE, The Cochrane Library and the ISI Science Citation Index and is assessed for inclusion in the Database of Abstracts of Reviews of Effects.This journal is a member of and subscribes to the principles of the Committee on Publication Ethics (COPE) (www.publicationethics.org/).Editorial contact: nihredit@southampton.ac.ukThe full HTA archive is freely available to view online at www.journalslibrary.nihr.ac.uk/hta. Print-on-demand copies can be purchased from the report pages of the NIHR Journals Library website: www.journalslibrary.nihr.ac.uk Criteria for inclusion in the Health Technology Assessment journalReports are published in Health Technology Assessment (HTA) if (1) they have resulted from work for the HTA programme, and (2) they are of a sufficiently high scientific quality as assessed by the reviewers and editors.Reviews in Health Technology Assessment are termed 'systematic' when the account of the search appraisal and synthesis methods (to minimise biases and random errors) would, in theory, permit the replication of the review by others. HTA programmeThe HTA programme, part of the National Institute for Health Research (NIHR), was set up in 1993. It produces high-quality research information on the effectiveness, costs and broader impact of health technologies for those who use, manage and provide care in the NHS. 'Health technologies' are broadly defined as all interventions used to promote health, prevent and treat disease, and improve rehabilitation and long-term care.The journal is indexed in NHS Evidence via its abstracts included in MEDLINE and its Technology Assessment Reports inform National Institute for Health and Care Excellence (NICE) guidance. HTA research is also an important source of evidence for National Screening Committee (NSC) policy decisions.For more information about the HTA programme please visit the website: www.hta.ac.uk/ This reportThe research reported in this issue of the journal was funded by the HTA programme as project number 08/53/33. The contractual start date was in April 2010. The draft report began editorial review in May 2012 and was accepted for publication in January 2013. The authors have been wholly responsible for all data collection, analysis and interpretation, and for writing up their work. The HTA editors and publisher have tried to ensure the accuracy of the authors' report and would like to thank the reviewers for their constructive comments on the draft document. However, they do not accept liability for damages or losses arising from material published in this report.This report presents independent research funded by the National Institute for Health Research (NIHR). The views and opinions expressed by authors in this publication are those of the authors and do not necessarily reflect those of the NHS, the NIHR, NETSCC, the HTA programme or the Department of Health. If there are verbatim quotations included in this publication the views and opinions expressed by the interviewees are thos...

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The impact of continuous haemofiltration with high-volume fluid exchange during cardiopulmonary bypass surgery on the recovery of patients with impaired renal function: a pilot randomised trial

Matata

Mediratta²,

Morgan³

et al. 2013

Health Technology Assessment

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“…Off-pump coronary artery bypass surgery (OPCAB) eliminates negative effects of CPB. This technique is considered to reduce the systemic inflammatory response and allow more appropriate physiological conditions for organ systems (5). OPCAB has recently gained popularity because it reduces morbidity and has positive effects on major organ systems (6).…”

Section: Introductionmentioning

confidence: 99%

Clinical significance of intestinal type fatty acid binding protein in patients undergoing coronary artery bypass surgery

Camkiran¹,

Dönmez²,

Aldemir³

et al. 2011

Anadolu Kardiyol Derg

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ÖZETAmaç: Çalışmamızın amacı, kardiyopulmoner baypas (KPB) uygulanan ve uygulanmayan (OPCAB) hastalarda intestinal iskemi ile intestinal yağ asidi bağlayıcı protein (I-FABP) arasında ilişki olup olmadığını belirlemektir. Yöntemler: Çalışma prospektif, gözlemsel olarak planlandı. Elektif koroner arter baypas greftleme cerrahisi uygulanacak 50-70 yaşları arasında hastalar ardışık olarak çalışmaya alındı. Kardiyopulmoner baypas uygulanan 35 hasta birinci grup (CPB), uygulanmayan 16 hasta ikinci grup (OPCAB) olarak kabul edildi. Gruplar arası ve grup içi karşılaştırmalar Student's t, Mann-Whitney U, Friedman ve Wilcoxon testleri ile analiz edildi. Bulgular: Kardiyopulmoner baypas uygulanan grubun I-FABP düzeylerinde operasyon sonunda, başlangıca göre anlamlı yükselme olurken (p<0.005), postoperatif 12. ve 24. saatlerde operasyon bitişine göre anlamlı düşme görüldü (sırasıyla p<0.001, p<0.001). Kardiyopulmoner baypas uygulanmayan grupta ise operasyon sonunda operasyon başlangıcına göre yükselme görülürken (p<0.001), postoperatif 24. saatte operasyon başlangıcına göre anlamlı düşme görüldü (p<0.001). Her iki grubun I-FABP düzeyleri cerrahi bitiminde preoperatif değerlere göre anlamlı şekilde yükseldi. Sonuç: Çalışmamız sırasında hiçbir hastamızda intestinal iskemi görülmezken, I-FABP düzeylerindeki değişiklik bize açık kalp cerrahisi geçiren hastalarda intestinal iskemi monitörizasyonunda I-FABP'nin kullanılabileceğini düşündürdü. ABSTRACTObjective: The aim of this study was to determine whether serum levels of intestinal type fatty acid binding protein (I-FABP) are related to intestinal ischemia in patients undergoing coronary bypass surgery. Methods: The study was planned as prospective, observational. Elective coronary artery bypass candidate patients between ages of 50 and 70 were consecutively included in the study. Thirty-five patients scheduled for cardiopulmonary bypass (CPB) were identified as the CPB group and 16 patients not scheduled for CPB were identified as the off-pump coronary artery bypass surgery (OPCAB) group. The variables between and within the groups were analyzed with Student's t, Mann-Whitney U, Friedman and Wilcoxon tests respectively. Results: In both CPB and OPCAB groups, I-FABP level at the end of the operation was significantly higher than that noted at the beginning of the operation (p<0.005). In the CPB group, there was a significant drop in I-FABP from the end of the operation to each of the postoperative time points (12 th hour and 24 th hour) (respectively p<0.001, p<0.001). In the OPCAB group, the I-FABP levels at both postoperative time points were lower than that at the end of the operation (p<0.001), and the level at 24-hour post-surgery was significantly lower than at both the end-of-operation I-FABP value (p<0.001) and the 12-hour post-surgery I-FABP value. Conclusion: Since we have not observed any intestinal ischemia through our research, slight changes of I-FABP measurements make us believe that I-FABP would be a valuable way to monitor for intestinal ischemia in patients w...

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“…Though the mortality for many of these operations has fallen, CPB is still associated with a significant morbidity [1]. CPB is known to activate inflammatory processes that may result in respiratory failure, bleeding disorders, neurologic dysfunction, and transient renal impairment [2]. Furthermore, CPB increases the production of inflammatory cytokines [1] and that cytokines are known to depress cardiac efficiency by mechanisms that are still unclear [3].…”

Section: Overviewmentioning

confidence: 99%

Characterization of anIn VitroModel of Extracorporeal Circulation: A New Tool for Investigating the Pathophysiological and Therapeutic Strategies in Whole Blood

Matata

Elahi

2013

ISRN Biomaterials

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A clinically relevant extracorporeal circulation model would be a valuable tool for investigating the pathophysiological and therapeutic strategies in whole blood. Previous models were limited by issues such as large circuit area; the inability to achieve full bypass; and donor blood requirement for prime. Here we established a miniature circuit to overcome these limitations consisting of a peristaltic pump, a test cell, a blood reservoir, and an oxygenator connected via polyvinylchloride and porous platinum silicon tubing. A heparinised (10 U/mL) saline solution at pH 7.4 was used to prime the circuit and the test cell was incubated in a water bath to maintain the temperature at 37 ∘ C. Blood flow through the circuit was at 5 mL/minute rate. Haemodynamics, haemoglobin concentration, and blood gases were analysed and the circuit performance was optimised according to the levels of haemolysis at three circulation time intervals: before the start, 30 minutes, and 60 minutes. No statistically significant haemodynamics and blood gases differences were observed. We have established a miniature extracorporeal circuit consisting of asanguineous prime for CPB model that maintains clinically acceptable results regarding hemodynamic parameters, blood gases, and haemodilution. This surrogate model would be important for further use in clinically pertinent research.

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Off-pump bypass graft operation significantly reduces oxidative stress and inflammation

Cited by 260 publications

References 20 publications

The impact of continuous haemofiltration with high-volume fluid exchange during cardiopulmonary bypass surgery on the recovery of patients with impaired renal function: a pilot randomised trial

The impact of continuous haemofiltration with high-volume fluid exchange during cardiopulmonary bypass surgery on the recovery of patients with impaired renal function: a pilot randomised trial

Clinical significance of intestinal type fatty acid binding protein in patients undergoing coronary artery bypass surgery

Characterization of anIn VitroModel of Extracorporeal Circulation: A New Tool for Investigating the Pathophysiological and Therapeutic Strategies in Whole Blood

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