Off-pump coronary artery bypass grafting with an aortic nonclamping technique may reduce the incidence of cerebral complications

Osawa, Hiroshi; Inaba, Hisashi; Kinoshita, Osamu; Akashi, Okihiko; Minegishi, Sachito

doi:10.1007/s11748-011-0795-z

Cited by 6 publications

(2 citation statements)

References 19 publications

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“…They concluded that the aortic nonclamping technique might reduce the incidence of stroke. Kobayashi, et al 38) also reported that there was no operative death or stroke by using an aorta no-touch technique with in-situ graft and composite and sequential grafting methods.…”

Section: Diabetes Mellitus (Dm)mentioning

confidence: 99%

Off-Pump Coronary Artery Bypass Grafting Revisited: Experience and Evidence from Japan

Doi

Okawa

2013

ATCS

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Off-pump coronary artery bypass grafting (OPCAB) is performed in about 65% of patients who require surgical coronary revascularization, and has become the standard procedure in coronary artery bypass grafting (CABG) in Japan. As a background of the high rate of OPCAB, many clinical and experimental studies have been performed and reported in Japan. In this review, several factors associated with OPCAB are discussed based on relevant and important clinical studies published in Japan in the English language.

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Section: Diabetes Mellitus (Dm)mentioning

confidence: 99%

Off-Pump Coronary Artery Bypass Grafting Revisited: Experience and Evidence from Japan

Doi

Okawa

2013

ATCS

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“…Cerebral infarction is a common neurological complication after cardiac surgery [ 9 ], The incidence of recessive cerebral infarction detected by diffusion-weighted magnetic resonance imaging is high as 50% [ 10 ]. Microemboli from cardiac surgery can block blood flow and cause ischemia and capillary loss [ 11 ], and hypoxia.…”

Section: Introductionmentioning

confidence: 99%

Mechanisms of hypoxia in the hippocampal CA3 region in postoperative cognitive dysfunction after cardiopulmonary bypass

Liu

Deng

Wang

et al. 2022

J Cardiothorac Surg

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Background Postoperative cognitive dysfunction (POCD) is a complication with high morbidity and mortality, commonly observed in the elderly who underwent anesthesia and surgery. The incidence is much higher in cardiac surgery. However, the reason and the mechanism of POCD remains unclear, but cerebral hypoxia is a common neurological complication after cardiac surgery. This study aims to investigate what role cerebral hypoxia plays in the pathogenesis of POCD. Methods The POCD model was established using cardiopulmonary bypass (CPB) surgery. Cognitive function was detected using Y maze and Morris water maze. The hypoxia in central nervous system was assessed using HE staining, western blot, and immunofluorescence. Inflammatory factors in hippocampus and plasma were detected by enzyme-linked immunosorbent assay. Evans blue was used to detect destruction of the blood brain barrier (BBB). Results Cognitive impairment markedly occurred to rats underwent 2-h CPB operation. Cerebral thrombosis and hypoxia occurred in the hippocampal CA3 region of rats after surgery. In addition, microglia in hippocampal was activated and the expression of inflammatory factors such as IL-1β, IL-6 and TNF-α was upregulated. Moreover, the permeability of BBB increased in rats after CPB. Conclusion Hypoxia in hippocampal CA3 region was involved in the occurrence and the mechanism may be associated with neuroinflammation and the damage of BBB.

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OPCAB Made in Japan: Evidence on Off-Pump Coronary Artery Bypass Grafting from Japan

Doi

2016

Off-Pump Coronary Artery Bypass

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Off-pump coronary artery bypass grafting with an aortic nonclamping technique may reduce the incidence of cerebral complications

Abstract: The aortic nonclamping technique might reduce the incidence of cerebral complications and produce ideal bypass grafts using arterial grafts and saphenous vein grafts with a proximal anastomosis device.

Cited by 6 publications

References 19 publications

Off-Pump Coronary Artery Bypass Grafting Revisited: Experience and Evidence from Japan

Off-Pump Coronary Artery Bypass Grafting Revisited: Experience and Evidence from Japan

Mechanisms of hypoxia in the hippocampal CA3 region in postoperative cognitive dysfunction after cardiopulmonary bypass

OPCAB Made in Japan: Evidence on Off-Pump Coronary Artery Bypass Grafting from Japan

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