Construction professionals work in silos and use traditional design and construction methods. The growing demand for rapidly built and high-quality construction is making off-site manufacturing mainstream. Studies have shown that collaboration among all stakeholders is a necessary component for success in the construction of such buildings. This multidisciplinary study of an existing concrete hotel aims to explore an alternative structural design in mass timber or volumetric modular construction. To this end, the reinforced concrete floor plan of Club Med de Charlevoix in Quebec, Canada, was used as a benchmark for two different structural systems. The first strategy investigated CLT (cross-laminated timber) and glulam columns to replicate the reinforced concrete system (column–slab), while the second involved maximum prefabrication (volumetric modular construction). Both mass timber and volumetric modular strategies can lead to a smaller carbon footprint. The main conclusion is that the plan should be designed from the outset to be either traditional or prefabricated since major changes are required if the choice is made to switch from one system to the other. Moreover, when structural systems maximize off-site construction, such as volumetric modular construction, the various professions need to be included during early planning. This is necessary to avoid task duplication and prevent the neglect of considerations such as manufacturable dimensions and partition organization.