‘Off the shelf’ immunotherapies: Generation and application of pluripotent stem cell‐derived immune cells

Wang, Chenxin; Liu, Jingjing; Li, Wei

doi:10.1111/cpr.13425

Cited by 9 publications

(4 citation statements)

References 177 publications

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“…A phase I/II clinical trial at the University of Miami is testing autologous CAR-T cells directed against BCMA in patients with generalized myasthenia gravis (NCT04146051). Additionally, a group at the University of Erlangen in Germany demonstrated the successful treatment of five patients with SLE and one patient with refractory antisynthetase syndrome using CD19 CAR-T cells [21][22][23].…”

Section: Car-t Cell Therapymentioning

confidence: 99%

Application of chimeric antigen receptor-natural killer cells for the treatment of type 1 diabetes

Steenblock,

Eitler,

Oikonomakos

et al. 2024

Explor Endocr Metab Dis

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For the past 100 years, insulin supplementation has been the mainstay of treatment for type 1 diabetes (T1D), which is characterized by progressive autoimmune-mediated loss of insulin-producing β cells in the islets of Langerhans over the last decades, technological advances in glucose monitoring and therapeutics have greatly improved the care and management of these patients. However, morbidity, mortality, and quality of life remain challenges for patients with T1D. Islet transplantation has been successfully performed, but there are several limiting factors, such as the lack of cadaveric donors and the need for lifelong immunosuppressive therapy. Therefore, there is a great medical need for alternative therapeutic approaches. In the current review, the current knowledge on novel approaches for the treatment of T1D with a focus on the potential of using chimeric antigen receptor (CAR)-T cells and natural killer (NK) cells is summarized.

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Section: Car-t Cell Therapymentioning

confidence: 99%

Application of chimeric antigen receptor-natural killer cells for the treatment of type 1 diabetes

Steenblock,

Eitler,

Oikonomakos

et al. 2024

Explor Endocr Metab Dis

View full text Add to dashboard Cite

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“…These functional properties may also be closely related to the neural repair capacity of fibroblast-derived ECMs. Stem cells have a unique capacity for self-renewal and multilineage differentiation as well as the potency to secrete various regulatory molecules, which contributes to forming a specialized niche and directing the development and regeneration of tissues [ 114 ]. ECMs derived from stem cells retain the specific functionality that can reflect in vivo microenvironment characteristics, and contain unique signaling networks to mediate cell behavior [ 115 , 116 ], which brings more opportunities to support peripheral nerve repair following injury.…”

Section: Functional Properties and Mechanisms Of Cd-ecmsmentioning

confidence: 99%

Engineering cell-derived extracellular matrix for peripheral nerve regeneration

Xu,

Liu,

Ahmad

et al. 2024

Materials Today Bio

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“… 7 Flow cytometry-based cell phenotyping is the primary method for conventional immune monitoring. 8 , 9 However, as a one-by-one measurement, the widespread application of flow cytometry, especially in health screening and under-resourced regions, is hindered by its technical-sensitive, high-cost, and time-consuming nature. 10 , 11 Moreover, the accuracy of flow cytometry in immune-cell phenotyping can be compromised owing to the antibody’s unspecific binding to the variants of immune markers.…”

Section: Introductionmentioning

confidence: 99%

DNA framework signal amplification platform-based high-throughput systemic immune monitoring

Chen,

Zhang

et al. 2024

Sig Transduct Target Ther

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Systemic immune monitoring is a crucial clinical tool for disease early diagnosis, prognosis and treatment planning by quantitative analysis of immune cells. However, conventional immune monitoring using flow cytometry faces huge challenges in large-scale sample testing, especially in mass health screenings, because of time-consuming, technical-sensitive and high-cost features. However, the lack of high-performance detection platforms hinders the development of high-throughput immune monitoring technology. To address this bottleneck, we constructed a generally applicable DNA framework signal amplification platform (DSAP) based on post-systematic evolution of ligands by exponential enrichment and DNA tetrahedral framework-structured probe design to achieve high-sensitive detection for diverse immune cells, including CD4+, CD8+ T-lymphocytes, and monocytes (down to 1/100 μl). Based on this advanced detection platform, we present a novel high-throughput immune-cell phenotyping system, DSAP, achieving 30-min one-step immune-cell phenotyping without cell washing and subset analysis and showing comparable accuracy with flow cytometry while significantly reducing detection time and cost. As a proof-of-concept, DSAP demonstrates excellent diagnostic accuracy in immunodeficiency staging for 107 HIV patients (AUC > 0.97) within 30 min, which can be applied in HIV infection monitoring and screening. Therefore, we initially introduced promising DSAP to achieve high-throughput immune monitoring and open robust routes for point-of-care device development.

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‘Off the shelf’ immunotherapies: Generation and application of pluripotent stem cell‐derived immune cells

Cited by 9 publications

References 177 publications

Application of chimeric antigen receptor-natural killer cells for the treatment of type 1 diabetes

Application of chimeric antigen receptor-natural killer cells for the treatment of type 1 diabetes

Engineering cell-derived extracellular matrix for peripheral nerve regeneration

DNA framework signal amplification platform-based high-throughput systemic immune monitoring

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