Oil Core/Polymer Shell Microcapsules by Internal Phase Separation from Emulsion Droplets. II:  Controlling the Release Profile of Active Molecules

Dowding, P.; Atkin, Rob; Vincent, Brian; Bouillot, Philippe

doi:10.1021/la0470838

Cited by 92 publications

(74 citation statements)

References 30 publications

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“…Protein nanocapsules could be prepared by various emulsification methods, such as single/double emulsions [59,60], polymerization [61], phase separation/coacervation [62], spray drying/spray congealing [63,64] and ultrasonic emulsification [65].…”

Section: Protein Nanocapsulesmentioning

confidence: 99%

Smart Nanocontainers: Preparation, Loading/Release Processes and Applications

Nguyen¹,

Assadi²

2018

IJNTR

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Section: Protein Nanocapsulesmentioning

confidence: 99%

Smart Nanocontainers: Preparation, Loading/Release Processes and Applications

Nguyen¹,

Assadi²

2018

IJNTR

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“…Aqueous core-PLGA shell microcapsules were prepared by internal phase separation method adapted from the Vincent group (9,(11)(12)(13) with modifications. This method involves preparation of two phases: internal acetone-water phase and external oil phase.…”

Section: Preparation Of Aqueous Core-plga Shell Microcapsulesmentioning

confidence: 99%

“…A specific amount of risedronate-loaded microparticles (25-30 mg) was dispersed in PBS (pH 6.8, 3 ml) and placed in a dialysis tube with a molecular weight cutoff 10-12 kDa. Dialysis bags were immersed in a glass vial containing PBS (pH 6.8, 30 ml) and placed in a shaker water bath (Heto Lab Equipment, Bromma, Denmark) at 37°C and 75 rpm (12,13,17,18). Released amounts of the drug were determined by collecting dialysate samples (2 ml) at certain time intervals and replaced immediately with the same volume of fresh PBS to maintain sink conditions.…”

Section: Determination Of Drug Loading and Encapsulation Efficiency Imentioning

confidence: 99%

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Synthesis and Characterization of PLGA Shell Microcapsules Containing Aqueous Cores Prepared by Internal Phase Separation

Abulateefeh

Alkilany

2015

AAPS PharmSciTech

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Abstract. The preparation of microcapsules consisting of poly(D,L-lactide-co-glycolide) (PLGA) polymer shell and aqueous core is a clear challenge and hence has been rarely addressed in literature. Herein, aqueous core-PLGA shell microcapsules have been prepared by internal phase separation from acetonewater in oil emulsion. The resulting microcapsules exhibited mean particle size of 1.1±0.39 μm (PDI=0.35) with spherical surface morphology and internal poly-nuclear core morphology as indicated by scanning electron microscopy (SEM). The incorporation of water molecules into PLGA microcapsules was confirmed by differential scanning calorimetry (DSC). Aqueous core-PLGA shell microcapsules and the corresponding conventional PLGA microspheres were prepared and loaded with risedronate sodium as a model drug. Interestingly, aqueous core-PLGA shell microcapsules illustrated 2.5-fold increase in drug encapsulation in comparison to the classical PLGA microspheres (i.e., 31.6 vs. 12.7%), while exhibiting sustained release behavior following diffusion-controlled Higuchi model. The reported method could be extrapolated to encapsulate other water soluble drugs and hydrophilic macromolecules into PLGA microcapsules, which should overcome various drawbacks correlated with conventional PLGA microspheres in terms of drug loading and release.

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“…Microcapsules also offer a larger loading capacity than microbubbles and present the advantage to be usable either as a slow-release drug carrier 405 or as an activated drug carrier 79 . Further attention thus was brought on loading polymer microcapsules, not only with drug molecules, but also with functional elements such as magnetic nanoparticles 406 .…”

Section: Introductionmentioning

confidence: 99%

Ultrasound contrast agents: bubbles drops and particles

Lajoinie¹

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The research described in this thesis is part of the research program NanoNextNL, a micro and nanotechnology consortium of the Government of the Netherlands and 130 partners. This thesis was carried out at the Physics of Fluids group of the Faculty of Science and Technology of the University of Twente. Cover design:As a representation of a crucial goal of this work, the cover depicts a confocal microscopy image showing cells selectively porated by loaded microbubbles upon ultrasound exposure. The porated cells take up a blue fluorescent probe. By Ine Lentacker, Ine De Cock and Guillaume Lajoinie. Guide through the thesisIn this thesis, we investigate different types of innovative agents, designed for biomedical use in a context of molecular imaging. In Chapter 1, we review the agents that arouse the interest of the scientific community, most of them at the research stage of development, together with the experimental methods that can be used to study their interaction with cells. Such in vitro investigations are necessary to test on short scales the impact of the various agents on biological structures.We separate the agents in three main categories. The first group consists of stabilized microbubbles, usually by means of phospholipids that fill up the interfacial area between the gas core and the surrounding liquid (water). Such bubbles are clinically used for 40 years as contrast agents for ultrasound owing to their unique resonance behavior. When irradiated with an ultrasound pulse, a bubble experiences volumetric oscillations, that reemit an ultrasound wave back to the transducer. This process makes them unchallenged ultrasound scatterers. The role of these stable microbubbles in new biomedical research directions is discussed in Chapters 2 to 9.Phospholipid coatings were developed in the last decade to do much more than just prevent bubble dissolution. They are now a crucial tool to enrich the microbubbles with specific markers or drug payloads. In Chapter 2, we investigate the behavior of this coating when the microbubbles are subjected to an ultrasound field. We show that the coating is shed away from the microbubble, which is of major interest for molecular imaging combined with drug delivery using microbubbles. We pursue the idea in Chapter 3 where we investigate how a bubble payload, here liposomes labeled with a fluorescent dye, is released under ultrasound exposure. In Chapter 4, we link these direct observations of shedding of the previous Chapters to the subsequent dissolution of the microbubbles, no longer protected by a phospholipid shell. This dissolution, visible in the ultrasound scatter spectrum can be used to remotely quantify the effect of the microbubbles. In support of these observations, we dedicate the next Chapter (Chapter 5) to physically understand the mechanisms underlying the behavior of the phospholipid coating. The application of these findings in practice requires the production a sufficiently high production rate and with great control of such microbubbles. In Chapter 6, we th...

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Oil Core/Polymer Shell Microcapsules by Internal Phase Separation from Emulsion Droplets. II: Controlling the Release Profile of Active Molecules

Cited by 92 publications

References 30 publications

Smart Nanocontainers: Preparation, Loading/Release Processes and Applications

Smart Nanocontainers: Preparation, Loading/Release Processes and Applications

Synthesis and Characterization of PLGA Shell Microcapsules Containing Aqueous Cores Prepared by Internal Phase Separation

Ultrasound contrast agents: bubbles drops and particles

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