Ointments with superoxide dismutase and interleukin-1β: Effect on reparative processes and impedance of burn wound

Paramonov, B. A.; Galenko-Yaroshevskii, V. P.; Turkovskii, I. I.; Zinoviev, E. V.; Churilova, I. V.; Gumenjuk, E S; Karnovich, A. G.

doi:10.1007/s10517-005-0211-8

Cited by 2 publications

(2 citation statements)

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“…An ointment formulation of SOD and interleukin‐1β was found to be effective on reparative processes of burn wounds, decreasing inflammation and accelerating wound‐healing 64 . This was supported in a study of experimentally scalded rats in which recombinant human CuZnSOD in three different formulations—native enzyme, enzyme‐loaded gel and enzyme‐loaded liposomes—reduced oedema, wound size and tissue necrosis.…”

Section: Antioxidant Enzymesmentioning

confidence: 85%

“…decreasing inflammation and accelerating wound-healing. 64 This was supported in a study of experimentally scalded rats in which recombinant human CuZnSOD in three different formulations-native enzyme, enzyme-loaded gel and enzyme-loaded liposomes-reduced oedema, wound size and tissue necrosis. The liposome formulation was also efficient in ROS scavenging, accelerating wound-healing processes.…”

Section: Superoxide Dismutasementioning

confidence: 89%

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Enzymes for dermatological use

Nascimento,

Torres‐Obreque,

Oliveira

et al. 2024

Experimental Dermatology

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Skin is the ultimate barrier between body and environment and prevents water loss and penetration of pathogens and toxins. Internal and external stressors, such as ultraviolet radiation (UVR), can damage skin integrity and lead to disorders. Therefore, skin health and skin ageing are important concerns and increased research from cosmetic and pharmaceutical sectors aims to improve skin conditions and provide new anti‐ageing treatments. Biomolecules, compared to low molecular weight drugs and cosmetic ingredients, can offer high levels of specificity. Topically applied enzymes have been investigated to treat the adverse effects of sunlight, pollution and other external agents. Enzymes, with a diverse range of targets, present potential for dermatological use such as antioxidant enzymes, proteases and repairing enzymes. In this review, we discuss enzymes for dermatological applications and the challenges associated in this growing field.

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Section: Antioxidant Enzymesmentioning

confidence: 85%

Section: Superoxide Dismutasementioning

confidence: 89%