1998
DOI: 10.1176/ajp.155.7.914
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Olanzapine Compared With Chlorpromazine in Treatment-Resistant Schizophrenia

Abstract: Olanzapine and chlorpromazine showed similar efficacy, and the total amount of improvement with either drug was modest. Olanzapine-treated patients had fewer side effects than chlorpromazine-treated patients.

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Cited by 216 publications
(115 citation statements)
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“…We propose that this pattern is associated with and represents a surrogate marker of the superior action of clozapine. As clozapine is the only second-generation antipsychotic with demonstrated superior efficacy (Conley et al, 1998;Breier et al, 1999;Wirshing et al, 1999), the mechanism of its therapeutic profile is particularly important to understand. The rCBF patterns identified here could lend guidance for preclinical antipsychotic models, strengthening or weakening current hypothesis.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…We propose that this pattern is associated with and represents a surrogate marker of the superior action of clozapine. As clozapine is the only second-generation antipsychotic with demonstrated superior efficacy (Conley et al, 1998;Breier et al, 1999;Wirshing et al, 1999), the mechanism of its therapeutic profile is particularly important to understand. The rCBF patterns identified here could lend guidance for preclinical antipsychotic models, strengthening or weakening current hypothesis.…”
Section: Discussionmentioning
confidence: 99%
“…Clozapine demonstrates a superior antipsychotic action in schizophrenia compared to other first-or second-generation antipsychotics (Kane et al, 1988;Conley et al, 1998;Breier et al, 1999;Wirshing et al, 1999;Kane et al, 2001). Moreover, in addition, it is not associated with Parkinsonism, akathisia, or tardive dyskinesia, and may improve cognitive function in schizophrenia (Buchanan and McKenna, 2000).…”
Section: Introductionmentioning
confidence: 99%
“…In 15 trials (Beasley 1996a, 168 Beasley 1997, 182 Jones 1998, 180,193 Tollefson 1997, 164 Altamura 1999, 181 HGCJ (Hong Kong) 1999, HGCU (Taiwan) 1998, HGFH (Korea) 1998, Reams 1998, 149 Gomez 2001, 150 Gregor 1999, 163 Zhang 1999, 156,157 Breier 2000, 159 Wright 2000, 151 Breier 2001 160 ), haloperidol was the comparator, while chlorpromazine was used in Conley 1998a, 183 Loza 1999, 185 In three studies (Beasley 1996a), the attrition rates were > 50% and data for all outcomes other than 'leaving study early' have been excluded.…”
Section: Olanzapine Versus Typical Antipsychotic Drugsmentioning
confidence: 99%
“…One recent study found no effect of high doses of olanzapine in treatment resistant schizophrenia (Conley et al 1998a), though there is limited published evidence that risperidone is effective in this patient group (Bondolfi et al 1998). However, there is extensive clinical experience that some patients who are refractory to typical neuroleptic drugs, and even clozapine, may respond to olanzapine or risperidone (Conley et al 1998b;Ganguli and Brar 1998;Mountjoy et al 1998 …”
Section: Treatment Resistant Schizophrenia and 5-ht 2a Receptor Blockadementioning
confidence: 99%