Olaratumab administered in two cases of phyllodes tumour of the breast: end of the beginning?

Kyriazoglou, Anastasios; Zagouri, Flora; Dimopoulos, Meletios A.

doi:10.1136/esmoopen-2018-000479

Cited by 9 publications

(7 citation statements)

References 25 publications

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“…We have recently published the poor outcome of Olaratumab administration to two patients with phyllodes tumor of the breast. 38 Herein, we report the potentially beneficial addition of Olaratumab to the 1st line treatment of metastatic hEHE.…”

Section: Discussionmentioning

confidence: 99%

<p>Metastatic Hepatic Epithelioid Hemangioendothelioma Treated with Olaratumab: A Falling Star Rising?</p>

Kyriazoglou

Koutsoukos

Zagouri

et al. 2020

TCRM

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Epithelioid hemangioendothelioma (EHE) is a rare vascular malignant tumor with indolent course. Liver transplantation for local disease is the treatment of choice. In the metastatic setting there is no consensus regarding the appropriate systemic treatment. We present two cases of metastatic hepatic epithelioid hemangioendothelioma (hEHE) treated with the combination of Doxorubicin and Olaratumab. Both patients showed Stable Disease (SD) as a response, after the completion of six cycles of this combination therapy.

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Section: Discussionmentioning

confidence: 99%

<p>Metastatic Hepatic Epithelioid Hemangioendothelioma Treated with Olaratumab: A Falling Star Rising?</p>

Kyriazoglou

Koutsoukos

Zagouri

et al. 2020

TCRM

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“…Radiotherapy remains a controversial topic but can be applied in local recurrences. Chemotherapy is reserved for malignant phyllodes with distant metastases that should be treated as a soft tissue sarcoma [ 3 , 30 ]. Mastectomy, performed in various fashions (simple, radical, radical extended, etc.)…”

Section: ⧉ Discussionmentioning

confidence: 99%

Diagnostic difficulties in giant benign phyllodes tumor

Matei

Mehedinţu-Ionescu²,

Paitici³

et al. 2022

Rom J Morphol Embryol

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Phyllodes tumors (PTs) are rare tumors of the breast, which encompass both stromal and epithelial components. The maximum incidence is in the fourth decade of life. Most of these tumors are benign, but about one third can be malignant acting as sarcomas. Due to their rarity and atypical clinical behavior (especially for the giant ones), the management of these tumors is usually difficult. We report a case of a 24-year-old woman who presented in the Department of Oncology for rapid increase in volume of the left breast. She had no personal pathological or family history. Initial clinical exam showed a large irregular mass in the left breast of approximately 30 cm and palpable lymph nodes in the ipsilateral axilla. A core needle biopsy for the tumor was performed with histopathological (HP) result that revealed an aspect suggesting fibroadenoma/PT. Contrast-enhanced computed tomography (CT) scan identified lymph node enlargement in the left axilla and a peripheral nodule in the lung about 5.5/3.4 mm with no specific features. The patient was then transferred to the Department of Surgery, where left mastectomy and axillary lymph node sampling were performed. HP result of the surgical specimens confirmed the presence of both fibroadenoma and PT, with clear margins above 1 cm, but recommended immunohistochemistry (IHC) to clearly specify benign versus borderline type. Five lymph nodes out of six resected presented microscopic reactive changes. We performed a search of literature using the keywords "giant", "benign" and "phyllodes". The results were used to summarize and discuss some of the main features of this type of tumors as well as diagnostic and therapeutic difficulties.

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“…Margin-negative resection combined with adjuvant radiotherapy is very effective for local control and prevention of recurrence [6]. Adjuvant chemotherapy is not the standard care since it is of controversial value for malignant phyllodes tumors, yet some institutions support doxorubicin-based adjuvant chemotherapy for rst-line treatment of breast sarcomas, especially with > 5.0 cm large high-risk tumors [22][23]. During postoperative follow-up, no local recurrence or distant metastasis were found.…”

Section: Discussionmentioning

confidence: 99%

Kiss Flaps to Repair Large Skin Defect After Excision of Giant Malignant Phyllodes Tumor of the Breast: A Case Report and Literature Review

Luo¹,

Zou²,

Hu³

et al. 2021

Preprint

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Background: Malignant phyllodes tumors of the breast are fairly rare and fast-growing tumors. They do not respond to chemotherapy or hormonal therapy except in malignant phyllodes tumors. Therefore, the primary treatment for malignant phyllodes tumors is wide surgical excision. Case presentation: Herein, we report a case study which featured a 26-year-old woman presented with a giant malignant phyllodes tumor measuring 20 × 17 × 13 cm. In order to reduce the chance of local recurrence, treatment for these types of tumors usually involves extensive excision with at least 1 cm of surgical margins. The patient underwent extended lumpectomy with 1-3 cm surgical margins, which left a large skin defect of 25 × 15 cm. Repair of such a large skin defect is a challenge to breast surgeons. This is the first reported case in which a “kiss” flap was successfully used to repair the skin defect created after resection of a giant malignant phyllodes tumor.Conclusions: The kiss flap could be considered as an effective method to repair large chest wall defects after resection of giant phyllodes tumors.

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Olaratumab administered in two cases of phyllodes tumour of the breast: end of the beginning?

Cited by 9 publications

References 25 publications

<p>Metastatic Hepatic Epithelioid Hemangioendothelioma Treated with Olaratumab: A Falling Star Rising?</p>

<p>Metastatic Hepatic Epithelioid Hemangioendothelioma Treated with Olaratumab: A Falling Star Rising?</p>

Diagnostic difficulties in giant benign phyllodes tumor

Kiss Flaps to Repair Large Skin Defect After Excision of Giant Malignant Phyllodes Tumor of the Breast: A Case Report and Literature Review

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