Old age as a risk factor for liver diseases: Modern therapeutic approaches

Georgieva, Milena; Xenodochidis, Charilaos; Krasteva, Natalia

doi:10.1016/j.exger.2023.112334

Experimental Gerontology

2023

DOI: 10.1016/j.exger.2023.112334

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Old age as a risk factor for liver diseases: Modern therapeutic approaches

Milena Georgieva,

Charilaos Xenodochidis,

Natalia Krasteva

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Cited by 7 publications

References 205 publications

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Is MASLD lost in translation in mice?

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Advances in the management of alcohol-associated liver disease

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et al. 2023

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Alcohol-associated liver disease (ALD) is a significant global health challenge, encompassing a spectrum from steatotic liver disease to cirrhosis and alcohol-associated hepatitis, and contributed to 25% of global cirrhosis deaths in 2019. The identification of both modifiable (e.g. heavy drinking, metabolic syndromes) and non-modifiable risk factors (e.g. genetic predispositions) is crucial for effective disease management. Alcohol use assessment and treatment, by using both behavioral therapy and pharmacotherapeutic modalities, nutrition support, and optimization of liver disease modifiers, form the cornerstone of management. Advances in medical therapies, such as fecal microbiota transplantation and novel agents such as IL-22, are being explored for their therapeutic potential. A unifying theme in ALD care is the need for a personalized approach to management, accounting for the spectrum of the disease and individual patient characteristics, to tailor interventions effectively. Finally, it is essential to address the challenges to effective ALD treatment, including socioeconomic, logistical, and stigma-related barriers, to improve patient outcomes. This review discusses the current knowledge on ALD, including epidemiology, pathophysiology, risk factors, and management strategies, highlighting the critical role of integrated care models.

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Old age as a risk factor for liver diseases: Modern therapeutic approaches

Cited by 7 publications

References 205 publications

Is MASLD lost in translation in mice?

Is MASLD lost in translation in mice?

The role and function of lncRNA in ageing-associated liver diseases

Advances in the management of alcohol-associated liver disease

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