“Old Drugs, New Tricks” – Local controlled drug release systems for treatment of degenerative joint disease

Tryfonidou, Marianna A.; Vries, Geert de; Hennink, Wim E.; Creemers, Laura B.

doi:10.1016/j.addr.2020.10.012

Cited by 42 publications

(25 citation statements)

References 175 publications

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“…Corticosteroids are widely used clinically as anti-inflammatory drugs and immunosuppressants, and their local injections are commonly used to relieve inflammatory pain caused by IVDD and OA. However, local injections of corticosteroids may pose serious risks due to systemic exposure and have short maintenance of efficacy, often requiring repeated injections ( Tryfonidou et al, 2020 ). Therefore, how to effectively prolong the local action time of drugs has always been the direction of researchers, and formulating drugs into microspheres is a promising strategy.…”

Section: Application Of Microsphere-based Delivery Systems In Ivddmentioning

confidence: 99%

New Hope for Treating Intervertebral Disc Degeneration: Microsphere-Based Delivery System

Guo

Zhang

et al. 2022

Front. Bioeng. Biotechnol.

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Intervertebral disc (IVD) degeneration (IVDD) has been considered the dominant factor in low back pain (LBP), and its etiological mechanisms are complex and not yet fully elucidated. To date, the treatment of IVDD has mainly focused on relieving clinical symptoms and cannot fundamentally solve the problem. Recently, a novel microsphere-based therapeutic strategy has held promise for IVD regeneration and has yielded encouraging results with in vitro experiments and animal models. With excellent injectability, biocompatibility, and biodegradability, this microsphere carrier allows for targeted delivery and controlled release of drugs, gene regulatory sequences, and other bioactive substances and supports cell implantation and directed differentiation, aiming to improve the disease state of IVD at the source. This review discusses the possible mechanisms of IVDD and the limitations of current therapies, focusing on the application of microsphere delivery systems in IVDD, including targeted delivery of active substances and drugs, cellular therapy, and gene therapy, and attempts to provide a new understanding for the treatment of IVDD.

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Section: Application Of Microsphere-based Delivery Systems In Ivddmentioning

confidence: 99%

New Hope for Treating Intervertebral Disc Degeneration: Microsphere-Based Delivery System

Guo

Zhang

et al. 2022

Front. Bioeng. Biotechnol.

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“…This disease often causes great pain and seriously affects the quality of life of patients. However, to date, there is still no effective drug to prevent disease progression, but only for alleviating pain [ 39 ]. However, Mongolian medicine has unique advantages and rich experience in the treatment of degenerative osteoarthrosis [ 40 ].…”

Section: Effects Of Mongolian Warm Acupuncture On Age-related Diseasesmentioning

confidence: 99%

Overview of Traditional Mongolian Medical Warm Acupuncture

et al. 2022

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Mongolian medical warm acupuncture is a traditional therapy of Mongolian medicine and was developed by people living on the Mongolian Plateau. This kind of traditional oriental medicine has a long history. The main characteristics of Mongolian medical warm acupuncture are the acupoints and the needles used. Its theory is based on the human anatomical structure and the distinct local culture. Mongolian medical warm acupuncture has been practiced for centuries and proved to be very effective in the treatment of age-related diseases, including the musculoskeletal and nervous diseases. This paper aims to briefly introduce the history and scope of Mongolian medical warm acupuncture, with a particular focus on age-related diseases, where Mongolian medical warm acupuncture has shown significant beneficial effects.

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“…IVDD is a leading chronic joint disease among the elderly population, seriously affecting the life quality of people ( Goh et al, 2019 ; Tryfonidou et al, 2020 ). Despite augmented studies focused on investigating the pathogenesis of the disease, many of the underlying mechanisms involved in IVDD remain largely unknown.…”

Section: Introductionmentioning

confidence: 99%

Extracellular Vesicles Derived From Stem Cells in Intervertebral Disc Degeneration

Sun

2022

Front. Cell Dev. Biol.

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Intervertebral disc degeneration (IVDD) is the leading cause of low back pain related to degradation of cartilaginous tissues, mainly resulting from oxidative stress, cell apoptosis, and extracellular matrix degradation. Extracellular vesicles (EVs) exist in all bodily fluids and can be produced by all types of cells. Stem cell-derived EVs (SC-EVs), which are the main paracrine components of stem cells, have gained significant attention in the field of regenerative medicine. Over the past years, accumulating evidence indicates the therapeutic and diagnostic potentials of EVs in IVDD. The main mechanisms involve the induction of regenerative phenotypes, apoptosis alleviation, and immune modulation. In addition, the efficiency of SC-EVs can be enhanced by choosing appropriate donor cells and cell phenotypes, optimizing cell culture conditions, or engineering EVs to deliver drugs and targeting molecules. Given the importance and novelty of SC-EVs, we give an overview of SC-EVs and discuss the roles of SC-EVs in IVDD.

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“Old Drugs, New Tricks” – Local controlled drug release systems for treatment of degenerative joint disease

Cited by 42 publications

References 175 publications

New Hope for Treating Intervertebral Disc Degeneration: Microsphere-Based Delivery System

New Hope for Treating Intervertebral Disc Degeneration: Microsphere-Based Delivery System

Overview of Traditional Mongolian Medical Warm Acupuncture

Extracellular Vesicles Derived From Stem Cells in Intervertebral Disc Degeneration

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