Older adults with cytomegalovirus reveal increased <scp>CD8</scp><sup>+</sup>/<scp>CD4</scp><sup>+</sup><scp>EMRA T</scp> cells and elevated systemic levels of kynurenic acid

Joisten, Niklas; Chirino, Tiffany Y. Wences; Boßlau, Tim Konstantin; Wasserfurth, Paulina; Hahn, Andreas; Krüger, Karsten; Zimmer, Philipp

doi:10.1111/imm.13609

Cited by 2 publications

(2 citation statements)

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“…Thus, the CMV serostatus does not appear to influence the exercise-induced change on the proportions of peripheral CD8 + T-cell subsets. However, significant between-subjects effects were found for the proportion of CD8 + EMRA T-cells, thereby suggesting a general effect of latent CMV infection on these cells, which is consistent with a recent paper published by the author’s group [ 34 ].…”

Section: Discussionsupporting

confidence: 91%

“…The effect of the intervention on the proportions of CD8 + T-cell subsets and the KYN pathway was analysed using rmANCOVA. For this, age, BMI and CMV serostatus, as well-described confounding factors for peripheral T-cell characteristics, and plasma levels of KYN pathway metabolites [ 17 , 34 ] were included as covariates in the model. An exploratory subgroup analysis was also performed with the CMV serostatus (pos./neg.)…”

Section: Methodsmentioning

confidence: 99%

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12-week combined strength and endurance exercise attenuates CD8+ T-cell differentiation and affects the kynurenine pathway in the elderly: a randomized controlled trial

et al. 2023

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Background Age-related accumulation of highly differentiated CD8+ effector memory re-expressing CD45RA (EMRA) T-cells and disruption of the kynurenine (KYN) pathway are associated with chronic inflammation and the development of insulin resistance. In this study the aim was to investigate the effects of 12-week combined strength and endurance exercise on CD8+ T-cell differentiation and KYN pathway metabolites. Ninety-six elderly subjects (f/m, aged 50—70) were randomized to a control (CON) or exercise (EX) group. The EX group completed combined strength and endurance training twice weekly for one hour each time at an intensity of 60% of the one-repetition maximum for strength exercises and a perceived exertion of 15/20 for endurance exercises. The EX group was also randomly subdivided into two groups with or without a concomitant balanced diet intervention in order to examine additional effects besides exercise alone. Before and after the intervention phase, the proportions of CD8+ T-cell subsets and levels of KYN pathway metabolites in peripheral blood were determined. Results The CD8+ EMRA T-cell subsets increased in the CON group but remained almost unchanged in the EX group (p = .02). Plasma levels of kynurenic acid (KA) increased in the EX group and decreased in the CON group (p = .03). Concomitant nutritional intervention resulted in lower levels of quinolinic acid (QA) compared with exercise alone (p = .03). Overall, there was a slight increase in the QA/KA ratio in the CON group, whereas it decreased in the EX group (p > .05). Conclusions Combined strength and endurance training seems to be a suitable approach to attenuate CD8+ T-cell differentiation in the elderly and to redirect the KYN pathway towards KA. The clinical relevance of these effects needs further investigation.

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Section: Discussionsupporting

confidence: 91%

Section: Methodsmentioning

confidence: 99%

12-week combined strength and endurance exercise attenuates CD8+ T-cell differentiation and affects the kynurenine pathway in the elderly: a randomized controlled trial

et al. 2023

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The effects of HCMV seropositivity and BMI degree on T cell immunophenotype in adults

Del Duca Lima,

Pires Dorneles,

Severo Ribeiro

et al. 2024

Obesity Medicine

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Older adults with cytomegalovirus reveal increased CD8⁺/CD4⁺EMRA T cells and elevated systemic levels of kynurenic acid

Cited by 2 publications

References 10 publications

12-week combined strength and endurance exercise attenuates CD8+ T-cell differentiation and affects the kynurenine pathway in the elderly: a randomized controlled trial

12-week combined strength and endurance exercise attenuates CD8+ T-cell differentiation and affects the kynurenine pathway in the elderly: a randomized controlled trial

The effects of HCMV seropositivity and BMI degree on T cell immunophenotype in adults

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Older adults with cytomegalovirus reveal increased CD8+/CD4+EMRA T cells and elevated systemic levels of kynurenic acid

Cited by 2 publications

References 10 publications

12-week combined strength and endurance exercise attenuates CD8+ T-cell differentiation and affects the kynurenine pathway in the elderly: a randomized controlled trial

12-week combined strength and endurance exercise attenuates CD8+ T-cell differentiation and affects the kynurenine pathway in the elderly: a randomized controlled trial

The effects of HCMV seropositivity and BMI degree on T cell immunophenotype in adults

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Older adults with cytomegalovirus reveal increased CD8⁺/CD4⁺EMRA T cells and elevated systemic levels of kynurenic acid