Older Human B Cells and Antibodies

Dunn-Walters, Deborah K.; O’Hare, Joselli Silva

doi:10.1007/978-3-319-64597-1_21-1

Cited by 3 publications

(3 citation statements)

References 186 publications

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“…The increased senescence markers, such as IL-1α/β, TNF-α, IL-6, and C-X-C motif chemokine ligand (CXCL)1, and cellular senescence facilitate bacterial adhesion to cells in the lungs [192], and may compromise upper respiratory mucosal immunity [193]. In addition, CD27+IgM+ B cells, which provide protection from Streptococcus pneumoniae and show age-related changes, may account for a reduced response to bacterial antigens [194].…”

Section: Bacterial Infectionsmentioning

confidence: 99%

The Impact of Immune System Aging on Infectious Diseases

Quiros-Roldan,

Sottini,

Natali

et al. 2024

Microorganisms

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Immune system aging is becoming a field of increasing public health interest because of prolonged life expectancy, which is not paralleled by an increase in health expectancy. As age progresses, innate and adaptive immune systems undergo changes, which are defined, respectively, as inflammaging and immune senescence. A wealth of available data demonstrates that these two conditions are closely linked, leading to a greater vulnerability of elderly subjects to viral, bacterial, and opportunistic infections as well as lower post-vaccination protection. To face this novel scenario, an in-depth assessment of the immune players involved in this changing epidemiology is demanded regarding the individual and concerted involvement of immune cells and mediators within endogenous and exogenous factors and co-morbidities. This review provides an overall updated description of the changes affecting the aging immune system, which may be of help in understanding the underlying mechanisms associated with the main age-associated infectious diseases.

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Section: Bacterial Infectionsmentioning

confidence: 99%

The Impact of Immune System Aging on Infectious Diseases

Quiros-Roldan,

Sottini,

Natali

et al. 2024

Microorganisms

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“…Likewise, they can neutralize toxins. The later maturation of B-cell affinity, dependent on the presence of T cells, is slower but results in the production of highly specific antibodies [137] (Figure 2).…”

Section: B Lymphocytes In the Follicles Of The Lymph Node And Aging-related Changes In The B Lymphocyte Microenvironmentmentioning

confidence: 99%

Aging-Related Cellular, Structural and Functional Changes in the Lymph Nodes: A Significant Component of Immunosenescence? An Overview

Cąkała-Jakimowicz

Kolodziej-Wojnar

Puzianowska-Kuźnicka

2021

Cells

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Aging affects all tissues and organs. Aging of the immune system results in the severe disruption of its functions, leading to an increased susceptibility to infections, an increase in autoimmune disorders and cancer incidence, and a decreased response to vaccines. Lymph nodes are precisely organized structures of the peripheral lymphoid organs and are the key sites coordinating innate and long-term adaptive immune responses to external antigens and vaccines. They are also involved in immune tolerance. The aging of lymph nodes results in decreased cell transport to and within the nodes, a disturbance in the structure and organization of nodal zones, incorrect location of individual immune cell types and impaired intercellular interactions, as well as changes in the production of adequate amounts of chemokines and cytokines necessary for immune cell proliferation, survival and function, impaired naïve T- and B-cell homeostasis, and a diminished long-term humoral response. Understanding the causes of these stromal and lymphoid microenvironment changes in the lymph nodes that cause the aging-related dysfunction of the immune system can help to improve long-term immune responses and the effectiveness of vaccines in the elderly.

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“…Ageing broadly impacts humoral immunity, as antibody affinity and the adaptive immune processes that lead to their production suffer with age [ 5 , 13 , 14 ]. For instance, plasma cells produce less antibody [ 15 ], germinal center B cell selection results in lower affinity antibodies in mouse [ 16 ], and the CD4+ T cell receptor diversity decreases [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

Age-associated changes in the circulating human antibody repertoire are upregulated in autoimmunity

Arvey¹,

Rowe²,

Legutki³

et al. 2020

Immun Ageing

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Background The immune system undergoes a myriad of changes with age. While it is known that antibody-secreting plasma and long-lived memory B cells change with age, it remains unclear how the binding profile of the circulating antibody repertoire is impacted. Results To understand humoral immunity changes with respect to age, we characterized serum antibody binding to high density peptide microarrays in a diverse cohort of 1675 donors. We discovered thousands of peptides that bind antibodies in age-dependent fashion, many of which contain di-serine motifs. Peptide binding profiles were aggregated into an “immune age” by a machine learning regression model that was highly correlated with chronological age. Applying this regression model to previously-unobserved donors, we found that a donor’s predicted immune age is longitudinally consistent over years, suggesting it could be a robust long-term biomarker of humoral immune ageing. Finally, we assayed serum from donors with autoimmune disease and found a significant association between “accelerated immune ageing” and autoimmune disease activity. Conclusions The circulating antibody repertoire has increased binding to thousands of di-serine peptide containing peptides in older donors, which can be represented as an immune age. Increased immune age is associated with autoimmune disease, acute inflammatory disease severity, and may be a broadly relevant biomarker of immune function in health, disease, and therapeutic intervention.

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Older Human B Cells and Antibodies

Cited by 3 publications

References 186 publications

The Impact of Immune System Aging on Infectious Diseases

The Impact of Immune System Aging on Infectious Diseases

Aging-Related Cellular, Structural and Functional Changes in the Lymph Nodes: A Significant Component of Immunosenescence? An Overview

Age-associated changes in the circulating human antibody repertoire are upregulated in autoimmunity

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