Oleander Poisoning as an Example of Self-Medication Attempt

Bavunoğlu, İşıl; Balta, Musa; Türkmen, Zeynep

doi:10.5152/balkanmedj.2016.150307

Cited by 14 publications

(15 citation statements)

References 9 publications

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“…Phytotherapeutic and nutritional use of plants and herbal-based products has (re)gained its popularity in the last years. Due to improper usage of plants or unawareness of plant toxicity, several intoxication cases with CG-containing plants have been reported recently [7,10,11]. Ingestion of toxic plant (parts) may also be possible through the food chain.…”

Section: Discussionmentioning

confidence: 99%

“…In a specific dose range, however, CGs such as digoxin (DIGO) and digitoxin (DIGI) (Figure 1), have a long history of use as medications in treating various heart conditions [1][2][3][4][5][6]. In the literature, numerous cases of human poisoning with plants containing CGs through self-medication, accidental ingestion, suicide attempts, or criminal administration have been documented [7][8][9][10][11]. These reports also included a remarkable case of intoxication with CGs through food [8].…”

Section: Introductionmentioning

confidence: 99%

“…A number of analytical, mostly single-analyte, methods for quantification of CGs in biological matrices have been described [11,[17][18][19][20][21][22][23][24]. As a detection technique, these methods utilized mass spectrometry (MS) coupled to liquid chromatography (LC), which, thanks to its good selectivity and sensitivity, has nowadays become the method of choice for many applications including toxin analysis.…”

Section: Introductionmentioning

confidence: 99%

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Development and Validation of a UHPLC-ESI-MS/MS Method for Quantification of Oleandrin and Other Cardiac Glycosides and Evaluation of Their Levels in Herbs and Spices from the Belgian Market

Malysheva

Mulder

Masquelier

2020

Toxins

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Cardiac glycosides (CGs) are naturally occurring plant secondary metabolites that can be toxic to humans and animals. The aim of this work was to develop a targeted analytical method utilizing liquid chromatography—tandem mass spectrometry (LC-MS/MS) for quantification of these plant toxins in a herbal-based food and human urine. The method included oleandrin, digoxin, digitoxin, convallatoxin, and ouabain. Samples of culinary herbs were extracted with acetonitrile and cleaned using Oasis® MAX solid-phase extraction (SPE), while samples of urine were diluted with acidified water and purified on Oasis® HLB SPE cartridges. Limits of quantification were in the range of 1.5–15 ng/g for herbs and 0.025–1 ng/mL for urine. The mean recovery of the method complied with the acceptable range of 70–120% for most CGs, and relative standard deviations were at maximum 14% and 19% for repeatability and reproducibility, respectively. Method linearity was good with calculated R² values above 0.997. The expanded measurement uncertainty was estimated to be in the range of 7–37%. The LC-MS/MS method was used to examine 65 samples of culinary herbs and herb and spice mixtures collected in Belgium, from supermarkets and local stores. The samples were found to be free from the analyzed CGs.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Development and Validation of a UHPLC-ESI-MS/MS Method for Quantification of Oleandrin and Other Cardiac Glycosides and Evaluation of Their Levels in Herbs and Spices from the Belgian Market

Malysheva

Mulder

Masquelier

2020

Toxins

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“…The toxicity is caused by “oleandrin” and “digitoxigenin” which are toxic cardiac glycosides 2 , 3 , 7 …”

Section: Discussionmentioning

confidence: 99%

“…In the past, it's used for producing cardiotonic medicine 2 . Both species are well known for their toxicity, however it's commonly used in the alternative medicine 3 . Nowadays studies are conducted on its use an anti-cancer medicine 4 .…”

Section: Introductionmentioning

confidence: 99%

Add oleander to your list of corrosives

Taşkın

Belli

Açıkalın

et al. 2019

Turkish Journal of Emergency Medicine

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Introduction Nerium oleander is a toxic ornamental plant which usually grows in the Mediterranean area. In the past it was used to produce cardiotonic medicine and there are studies on using this plant as an anti-cancer medicine and on its use in alternative medicine for many causes. Case Presentation Our case was of a 36 years old male who came to the emergency department with sore throat and burning feel in the throat following his curious bite of the oleander leaf. He had no trouble of breathing. The physical examination of the mouth showed burn-like lesions and edema of the uvula, oropharyngeal hyperemia, congestion and on the second day; necrosis. The edema and necrosis were later reduced with the treatment. We discharged the patient after observing for three following days without any complications or side effects. Conclusion Besides the systemic effects of the oleander plant, this case demonstrates that it could cause serious tissue necrosis when applied locally and corrosive esophagitis when taken by oral way. Patients must be examined and followed also for local toxic effects.

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Quantitative evaluation of cardiac glycosides and their seasonal variation analysis in Nerium oleander using UHPLC‐ESI‐MS/MS

Singh

Nimoriya

Rawat

et al. 2022

Phytochemical Analysis

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Introduction: Nerium oleander is an eminent source of structurally diverse cardiac glycosides (CGs), plays a prominent role in the treatment of heart failure, and inhibits the proliferation of cancer cell lines. CGs exert their cardiotonic action by binding to the extracellularly exposed recognition sites on Na + /K + -ATPase, an integral membrane protein that establishes the electrochemical gradient of Na + and K + ions across the plasma membrane.Objective: We aimed to quantitatively determine CGs and their seasonal variation in leaf and stem samples of N. oleander utilizing UHPLC-ESI-MS/MS techniques. Methods:The UHPLC-ESI-MS/MS analytical method was developed utilizing multiple reaction monitoring (MRM) mode. The Waters BEH C18 (150 mm Â 2.1 mm, 1.7 μm) column was used with a 22-min linear gradient consisting of acetonitrile and 5 mM ammonium acetate buffer.Results: In total 21 CGs were quantitatively determined in the seasonal leaf and stem samples of N. oleander along with the absolute quantitation of the three chemical markers odoroside H (244.8 μg/g), odoroside A (231.4 μg/g), and oleandrin (703.9 μg/g). The season-specific accumulation of chemical markers was observed in the order of predominance odoroside A (summer season, stem), odoroside H (winter season, stem), and oleandrin (rainy season, leaf). Besides this, the remaining 18 CGs were relatively quantified in the same samples. Conclusion:The developed method is simple and reliable and can be used for the identification and quantification of multiple CGs in N. oleander.

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Oleander Poisoning as an Example of Self-Medication Attempt

Abstract: This case represents the misunderstanding of herbal treatments by the community. Promoting awareness of the potential toxicity of this plant among the public may help to reduce the incidence of poisoning due to Nerium species.

Cited by 14 publications

References 9 publications

Development and Validation of a UHPLC-ESI-MS/MS Method for Quantification of Oleandrin and Other Cardiac Glycosides and Evaluation of Their Levels in Herbs and Spices from the Belgian Market

Development and Validation of a UHPLC-ESI-MS/MS Method for Quantification of Oleandrin and Other Cardiac Glycosides and Evaluation of Their Levels in Herbs and Spices from the Belgian Market

Add oleander to your list of corrosives

Quantitative evaluation of cardiac glycosides and their seasonal variation analysis in Nerium oleander using UHPLC‐ESI‐MS/MS

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