Oleic acid inhibits cholesteryl esterase and cholesterol utilization for testosterone synthesis in mouse leydig cells

Meikle, A.W.; Sousa, Jose C. Cardoso De; Hanzalová, Jitka; Murray, Darrell K.

doi:10.1016/s0026-0495(96)90281-4

Cited by 23 publications

(14 citation statements)

References 31 publications

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“…The dominance of PUFAs in the membrane of organelles present in testis cause susceptibility to lipid peroxidative degradation (Gutteridge et al 1998). It has been suggested that excessive PUFAs may be deleterious for testosterone production (Bourre et al 1997;Meikle et al 1989Meikle et al , 1996. This might explain the decrease in testosterone level in the present study.…”

Section: Discussionmentioning

confidence: 44%

Effects of clothianidin exposure on sperm quality, testicular apoptosis and fatty acid composition in developing male rats

et al. 2012

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Clothianidin (CTD) is one of the latest members of the synthetic organic insecticides, the neonicotinoids. In the present study, it was aimed to investigate if daily oral administration of CTD at low doses for 90 days has any deleterious effects on reproductive functions of developing male rats. Animals were randomly divided into four groups of six rats each, assigned as control rats, or rats treated with 2 (CTD-2), 8 (CTD-8) or 32 (CTD-32) mg CTD/kg body weight by oral gavage. The significant decreases of the absolute weights of right cauda epididymis and seminal vesicles, and body weight were detected in the animals exposed to CTD administration at 32 mg/kgBW/day. Epididymal sperm concentration decreased significantly in CTD-32 group and the abnormal sperm rates increased in CTD-8 and CTD-32 groups when compared to control group. The testosterone level was significantly decreased in CTD-32 group when compared to control group. The administration of all CTD doses resulted in a significant decrease in the level of GSH. The number of TUNEL-positive cells significantly increased in the germinal epithelium of testis of rats exposed to CTD at 32 mg/kgBW/day. In groups CTD-8 and CTD-32, only docosapentaenoic, arachidonic, palmitic and palmitoleic acids were significantly elevated when compared to control. The ratios of 20:4/18:2 and 18:1n-9/18:0 were decreased when rats exposed to CTD. Sperm DNA fragmentation was observed in CTD-32 group, but not CTD-2 and CTD-8. It is concluded that low doses of CTD exposure during critical stages of sexual maturation had moderate detrimental effects on reproductive organ system and more severe effects are likely to be observed at higher dose levels. In addition, the reproductive system may be more sensitive to exposure of CTD even earlier in development (prenatal and early postnatal), and therefore it could be expected that more severe effects could also be observed at the NOAEL dose levels, if dosing had occurred in utero or early postnatal.

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Section: Discussionmentioning

confidence: 44%

Effects of clothianidin exposure on sperm quality, testicular apoptosis and fatty acid composition in developing male rats

et al. 2012

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“…Linoleic acid may come from cholesteryl ester hydrolysis as cholesterol is mainly esterified with linoleic acid. Oleic acid reduces LH-induced hydrolysis of cholesteryl esters (Meikle et al 1996), which might explain the small linoleic acid proportion in A-FF, as they have a greater oleic acid proportion. Linoleic acid can also serve as a precursor for prostaglandins and leucotrienes, which have potent effects as local hormones.…”

Section: Discussionmentioning

confidence: 99%

Plasma and Follicular Fluid Fatty Acid Profiles in Dairy Cows

Renaville

Bacciu

Comin

et al. 2010

Reprod Domestic Animals

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Composition of follicular fluid to which the preovulatory follicle is exposed may be one of the major factors determining subsequent fertility, as fatty acids are a precursor of hormones involved in dominance, ovulation and atresia mechanisms. The objective of this paper is to observe fatty acid profiles in various lipid classes according to estrogenic activity of follicles. For each of the 18 cows, we analysed plasma and follicular fluid fatty acid profiles of phospholipids, non-esterified fatty acid (NEFA), cholesteryl esters and triglycerides fractions. Follicles were classified as active (ratio oestrogen to progesterone E2/P4 > 1) and inactive (E2/P4 < 1). For seven cows, we get both types of follicles, six had only one active follicle and five cows had only one inactive follicle. The NEFA profile for palmitic acid, stearic acid, oleic acid, linoleic acid, C20:3n6, arachidonic acid and docosapentaenoic acid (DPA; p < 0.001) is different between inactive and active follicles and plasma. Compared with active follicular fluid and plasma, follicular fluid of inactive follicles showed lower stearic acid, higher oleic acid, arachidonic acid and DPA (p < 0.05) in phospholipids. No significant differences were observed in the cholesteryl ester fraction, which is composted mainly of linoleic acid. Triglyceride concentrations were too low to get reliable results. This study suggests that follicles have a specific fatty acid metabolism depending on oestrogen activity.

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“…One interesting finding in the present study was that the consumption of GC at 400 mg⁄kg decreased the weight of the prostate while body weight was increased. Similarly, hyper doses of GC have a reverse effect on genital gonads as described by Meikle et al (1996). In another example, high doses of oleic acid inhibited cholesterol esterase that is essential for the synthesis of testosterone in the Leydig cells.…”

Section: Kamani M; Mhabadi J A; Atlasi M A; Seyedi F; Kamanmentioning

confidence: 94%

Protective Effect of Alcoholic Extract of Garden Cress Seeds on the Histopathological Changes of the Ventral Prostate in Streptozotocin Diabetic Rats

et al. 2017

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KAMANI, M.; MHABADI, J. A.; ATLASI, M. A.; SEYEDI, F.; KAMANI, E. & NIKZAD, H.Protective effect of alcoholic extract of garden cress seeds on the histopathological changes of the ventral prostate in streptozotocin diabetic rats. Int. J. Morphol., 35(3):1178Morphol., 35(3): -1184Morphol., 35(3): , 2017. SUMMARY:Diabetes mellitus is a common serious metabolic illness occurring worldwide that may lead to male infertility. Various plants have been used in the treatment of diabetes. In this study, the effect of garden cress (Lepidium sativum) seed extract on fasting blood sugar is assessed for its protective effect on histopathological changes in the ventral prostate gland of streptozotocine-induced diabetic rats. Fifty adult male Wistar rats were randomly selected into five groups. Group 1 was the control placebo group where rats received only 0.1 mL normal saline via gastric gavages. Rats in Group 2 received an intraperitoneal injection of STZ 60 mg/kg body weight and those with FBS >250 mg/dL were considered diabetic. In Group 3, diabetic rats received insulin (3 U/100 g body weight) while in Groups 4 and 5 diabetic rats received 0.1 ml of 200 and 400 mg/kg respectively of an ethanol extract of Lepidium sativum seeds by gavage daily. The prostate was removed and weighed before transfer to Bouin's solution for histological studies. Administration of the 200 and 400 mg/kg doses of Lepidium sativum seed extract increased epithelium height and decreased interstitial volume density and fibromuscular thickness of the prostate significantly. Also, the volume density of the epithelium, fibro muscular, lumen, and interstitial tissues were changed significantly. The results suggest that Lepidium sativum seed extract has beneficial effects as a protective agent against the detrimental effects of diabetes on the reproductive system of diabetic male rats.

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Oleic acid inhibits cholesteryl esterase and cholesterol utilization for testosterone synthesis in mouse leydig cells

Cited by 23 publications

References 31 publications

Effects of clothianidin exposure on sperm quality, testicular apoptosis and fatty acid composition in developing male rats

Effects of clothianidin exposure on sperm quality, testicular apoptosis and fatty acid composition in developing male rats

Plasma and Follicular Fluid Fatty Acid Profiles in Dairy Cows

Protective Effect of Alcoholic Extract of Garden Cress Seeds on the Histopathological Changes of the Ventral Prostate in Streptozotocin Diabetic Rats

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