Oleosin Cor a 15 is a novel allergen for Italian hazelnut allergic children

Nebbia, Stefano; Lamberti, Cristina; Cirrincione, Simona; Acquadro, Alberto; Abbà, Simona; Ciuffo, M.; Marinoni, Daniela Torello; Manfredi, Marcello; Marengo, Emílio; Calzedda, Roberta; Monti, Giovanna; Cavallarin, Laura; Giuffrida, Maria Gabriella

doi:10.1111/pai.13579

Cited by 13 publications

(4 citation statements)

References 24 publications

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“…It may even be helpful for the diagnosis of peanut allergic individuals without IgE against Ara h 2 and sesame allergic individuals without IgE to seed storage proteins. 1597 IgE-detection assay: So far, a recombinant oleosin from peanut is now applied on the ALEX2 array 44,1598 (A naturally purified hazelnut oleosin was used in ImmunoCAP in the investigation by Datema et al 44 but is not yet commercially available).…”

Section: -Clinical Managementmentioning

confidence: 99%

EAACIMolecular Allergology User's Guide 2.0

Dramburg

Hilger

Santos

et al. 2023

Pediatric Allergy Immunology

121

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Since the discovery of immunoglobulin E (IgE) as a mediator of allergic diseases in 1967, our knowledge about the immunological mechanisms of IgE‐mediated allergies has remarkably increased. In addition to understanding the immune response and clinical symptoms, allergy diagnosis and management depend strongly on the precise identification of the elicitors of the IgE‐mediated allergic reaction. In the past four decades, innovations in bioscience and technology have facilitated the identification and production of well‐defined, highly pure molecules for component‐resolved diagnosis (CRD), allowing a personalized diagnosis and management of the allergic disease for individual patients. The first edition of the “EAACI Molecular Allergology User's Guide” (MAUG) in 2016 rapidly became a key reference for clinicians, scientists, and interested readers with a background in allergology, immunology, biology, and medicine. Nevertheless, the field of molecular allergology is moving fast, and after 6 years, a new EAACI Taskforce was established to provide an updated document. The Molecular Allergology User's Guide 2.0 summarizes state‐of‐the‐art information on allergen molecules, their clinical relevance, and their application in diagnostic algorithms for clinical practice. It is designed for both, clinicians and scientists, guiding health care professionals through the overwhelming list of different allergen molecules available for testing. Further, it provides diagnostic algorithms on the clinical relevance of allergenic molecules and gives an overview of their biology, the basic mechanisms of test formats, and the application of tests to measure allergen exposure.

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Section: -Clinical Managementmentioning

confidence: 99%

EAACIMolecular Allergology User's Guide 2.0

Dramburg

Hilger

Santos

et al. 2023

Pediatric Allergy Immunology

121

View full text Add to dashboard Cite

show abstract

“…Not all RNA transcripts are translated into functional proteins therefore, out of all the single-target omics approaches, proteomics provides the strongest predictive power (68), likely due to proteins being one of the closest measures for biological activity in the cell. Although many studies have used proteomics for the identification of novel allergenic peptides (69)(70)(71)(72)(73)(74), only a few studies have leveraged the power of proteomics for FA development.…”

Section: Proteomics In Fa Developmentmentioning

confidence: 99%

Advances and potential of omics studies for understanding the development of food allergy

et al. 2023

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The prevalence of food allergy continues to rise globally, carrying with it substantial safety, economic, and emotional burdens. Although preventative strategies do exist, the heterogeneity of allergy trajectories and clinical phenotypes has made it difficult to identify patients who would benefit from these strategies. Therefore, further studies investigating the molecular mechanisms that differentiate these trajectories are needed. Large-scale omics studies have identified key insights into the molecular mechanisms for many different diseases, however the application of these technologies to uncover the drivers of food allergy development is in its infancy. Here we review the use of omics approaches in food allergy and highlight key gaps in knowledge for applying these technologies for the characterization of food allergy development.

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“…In hazelnuts, known oleosins are Cor a 12 and Cor a 13, with an unclear clinical significance [ 62 ]. A new hazelnut oleosin named Cor a 15 has recently been identified as a possible cause of reactions to hazelnuts in a subgroup of pediatric patients [ 75 ].…”

Section: Diagnostic Considerationsmentioning

confidence: 99%

Natural History of Hazelnut Allergy and Current Approach to Its Diagnosis and Treatment

et al. 2023

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Hazelnut allergy is the most prevalent type of nut allergy in Europe, with symptoms that can range from mild, such as hives and itching, to severe, such as anaphylaxis, particularly in patients who are sensitized to highly stable allergens, such as storage proteins. Compared to other types of food allergies, allergies to tree nuts, including hazelnuts, tend to persist throughout life. Although symptoms can appear in early childhood, they often continue into adulthood, with a minority of cases improving during adolescence. Currently, there is no curative treatment available for hazelnut allergy, and patients must adhere to a restrictive diet and carry autoinjective epinephrine. However, oral allergen immunotherapy (AIT) is a promising treatment option. Patients can be categorized based on their risk for severe reactions using various clinical, in vivo, and in vitro tests, including component-resolved diagnosis and oral food challenge. This review aims to provide an overview of the current knowledge of the natural history of hazelnut allergy and new approaches for its diagnosis and management.

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Oleosin Cor a 15 is a novel allergen for Italian hazelnut allergic children

Abstract: This is an open access article under the terms of the Creat ive Commo ns Attri bution-NonCo mmercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

Cited by 13 publications

References 24 publications

EAACIMolecular Allergology User's Guide 2.0

EAACIMolecular Allergology User's Guide 2.0

Advances and potential of omics studies for understanding the development of food allergy

Natural History of Hazelnut Allergy and Current Approach to Its Diagnosis and Treatment

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