Olfactory receptor Olfr544 responding to azelaic acid regulates glucagon secretion in α-cells of mouse pancreatic islets

Kang, NaNa; Bahk, Young Yil; Lee, Mi Kyung; Jae, Y Ro; Cho, Yoon Hee; Ku, Cheol Ryong; Byun, Youngjoo; Kim, Min Soo; Koo, Jae Hyung

doi:10.1016/j.bbrc.2015.03.078

Cited by 57 publications

(62 citation statements)

References 32 publications

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“…One study suggested the ectopic expression of Olfr544 in the αTC1-9 pancreatic α-cell line. The study showed that AzA increases the intracellular calcium level so that it has a marginal role in glucagon secretion (11). These results suggest that activation of Olfr544 by AzA may be tissue specific.…”

Section: Long-term Aza-induced Activation Of Olfr544 Reduces Adipositmentioning

confidence: 80%

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Olfactory receptor 544 reduces adiposity by steering fuel preference toward fats

Wu¹,

Hwang²,

Jia³

et al. 2017

Journal of Clinical Investigation

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Section: Long-term Aza-induced Activation Of Olfr544 Reduces Adipositmentioning

confidence: 80%

“…Azelaic acid (AzA) and suberic acid are known Olfr544 ligands (10,11). We examined the effect of Olfr544 in Hana3A cells transfected with N-terminal Lucy-FLAG-tagged Olfr544.…”

Section: Activation Of Olfr544 By Azelaic Acid Stimulates Camp Responmentioning

confidence: 99%

Olfactory receptor 544 reduces adiposity by steering fuel preference toward fats

Wu¹,

Hwang²,

Jia³

et al. 2017

Journal of Clinical Investigation

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“…Recent studies have reported that OMP and ORs are expressed in non-olfactory tissues, including the pancreas, colon, bladder, and thyroid gland 15,18,[28][29][30] . However, there have been no previous investigations on the expression and physiological functions of OMP in the pituitary gland.…”

Section: Discussionmentioning

confidence: 99%

“…However, it is not known whether OMP function is conserved across tissues. Recent studies have suggested a link between OMP and the endocrine system, especially in neuroendocrine neoplasia and hormone secretion [15][16][17][18] . However, to date, there have been no studies investigating the role of OMP in the functioning of the pituitary gland, which is considered the master regulator of the neuroendocrine system.…”

Section: Introductionmentioning

confidence: 99%

Olfactory marker protein regulates prolactin secretion and production by modulating Ca2+ and TRH signaling in lactotrophs

Ku¹,

Kang²,

Kim³

et al. 2018

EJEA

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Olfactory marker protein (OMP) is a marker of olfactory receptor-mediated chemoreception, even outside the olfactory system. Here, we report that OMP expression in the pituitary gland plays a role in basal and thyrotropin-releasing hormone (TRH)-induced prolactin (PRL) production and secretion. We found that OMP was expressed in human and rodent pituitary glands, especially in PRL-secreting lactotrophs. OMP knockdown in GH4 rat pituitary cells increased PRL production and secretion via extracellular signal-regulated kinase (ERK)1/2 signaling. Real-time PCR analysis and the Ca 2+ influx assay revealed that OMP was critical for TRH-induced PRL secretion. OMP-knockout mice showed lower fertility than control mice, which was associated with increased basal PRL production via activation of ERK1/2 signaling and reduced TRH-induced PRL secretion. However, both in vitro and in vivo results indicated that OMP was only required for hormone production and secretion because ERK1/2 activation failed to stimulate cell proliferation. Additionally, patients with prolactinoma lacked OMP expression in tumor tissues with hyperactivated ERK1/2 signaling. These findings indicate that OMP plays a role in PRL production and secretion in lactotrophs through the modulation of Ca 2+ and TRH signaling.

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“…1A) [5–7]. While this signaling pathway is obligatory for olfaction (mice null for AC3 cannot smell), the components of this pathway are also expressed outside of the nose [13; 56–58], and one of these sites is the kidney. AC3 and G olf are both expressed in the murine kidney at the transcript and protein level [59], and antibodies have localized them to the distal convoluted tubule and to an extremely specialized structure known as the macula densa (MD).…”

Section: Characterizing or Signaling In The Kidneymentioning

confidence: 99%

How does your kidney smell? Emerging roles for olfactory receptors in renal function

Shepard

Pluznick

2015

Pediatr Nephrol

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Olfactory receptors (ORs) are chemosensors that are responsible for one’s sense of smell. In addition to this specialized role in the nose, recent evidence suggests that ORs are also found in a variety of additional tissues including the kidney. As this list of renal ORs continues to expand, it is becoming clear that these ORs play important roles in renal and whole-body physiology, including a novel role in blood pressure regulation. In this review, we highlight important considerations that are crucial when studying ORs, and present the current literature on renal ORs and their emerging relevance in maintaining renal function.

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Olfactory receptor Olfr544 responding to azelaic acid regulates glucagon secretion in α-cells of mouse pancreatic islets

Cited by 57 publications

References 32 publications

Olfactory receptor 544 reduces adiposity by steering fuel preference toward fats

Olfactory receptor 544 reduces adiposity by steering fuel preference toward fats

Olfactory marker protein regulates prolactin secretion and production by modulating Ca2+ and TRH signaling in lactotrophs

How does your kidney smell? Emerging roles for olfactory receptors in renal function

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