Olfactory toxicity in fishes

Tierney, Keith B.; Baldwin, David H.; Hara, Toshiaki; Ross, Peter S.; Scholz, Nathaniel L.; Kennedy, Christopher J.

doi:10.1016/j.aquatox.2009.09.019

Cited by 280 publications

(189 citation statements)

References 154 publications

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“…But also, lower AChE activity level, it can interfere with olfaction, and make it more difficult for fish to detect prey and avoid predators (Tierney et al, 2010). Pesticides were widely detected in the Shima River and Danshui River.…”

Section: Discussionmentioning

confidence: 99%

Multi-biomarker responses as indication of contaminant effects in Gambusia affinis from impacted rivers by municipal effluents

Huang

Liu

Liang

et al. 2016

Science of The Total Environment

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Section: Discussionmentioning

confidence: 99%

Multi-biomarker responses as indication of contaminant effects in Gambusia affinis from impacted rivers by municipal effluents

Huang

Liu

Liang

et al. 2016

Science of The Total Environment

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“…sampled by Fisheries Queensland from the inner harbour were reported to have elevated aluminium levels in pooled gill samples (260 mg kg −1 wet weight) (Department of Employment, Economic Development and Innovation 2012). Moreover, water testing at the peak of disease event (Vision Environment 2011c) revealed dissolved zinc at levels (20 µg l −1 ) known to impact immune function (Zelikoff 1993), dissolved copper at levels (2 µg l −1 ) known to impact olfactory sensation (Mirza et al 2009, Tierney et al 2010, and dissolved aluminium at levels (30 µg l −1 and up to 334 µg l −1 ; Angel et al 2012) known to impact gill health and function in fishes (Teien et al 2006, Kroglund et al 2012, Thorstad et al 2013. A range of metals, at levels well surpassing those re ported for marine megafauna, as well as other contaminants were ob served in the blood and tissues of Gladstone green turtles Chelonia mydas during mid-2011 and could be linked to the pathology observed in stranded or dead turtles (Gaus et al 2012, Flint et al 2015.…”

Section: Discussionmentioning

confidence: 99%

Pathology of finfish and mud crabs Scylla serrata during a mortality event associated with a harbour development project in Port Curtis, Australia

Dennis¹,

Diggles²,

Faulder³

et al. 2016

Dis. Aquat. Org.

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“…Indeed, citric acid was identified as a potent gustatory feeding stimulant in zebrafish (Kasumyan and Doving, 2003). Furthermore, acute exposure to pH <4.0 can cause pathological alteration of the olfactory epithelium (Daye and Garside, 1976) and low pH interferes with chemoreceptors responsible for both olfaction (Tierney et al, 2010) and gustation (Kasumyan, 2001). Acute exposure to low pH can extinguish or change behavioral responses to odors, including attraction to previously repulsive chemicals (Royce-Malmgren and Watson, 1987).…”

mentioning

confidence: 99%

“…Injection inflicts fewer negative effects on the welfare of wild fishes whereas chemicals used in tank immersion enter waste water and, ultimately, the environment as organic contaminants (Tierney et al, 2010).…”

mentioning

confidence: 99%

Responses of larval zebrafish to low pH immersion assay. Comment on Lopez-Luna et al.

Diggles

Arlinghaus

Browman

et al. 2017

Journal of Experimental Biology

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Lopez -Luna et al. (2017) observed behavioral responses of larval zebrafish (Danio rerio) exposed for 10 min to pH 2.6-3.6 when acetic acid (0.01-0.25%) or citric acid (0.1-5%) was added to the tank water in the presence or absence of aspirin (1-2.5 mg l −1 ), morphine sulfate (1-48 mg l −1 ), lidocaine (1-5 mg l −1 ) and flunixin (8-20 mg l −1 ). Fish exposed to 0.1-0.25% acetic acid were less active than controls while those exposed to citric acid and 0.01% acetic acid were more active. Administration of high doses of aspirin, morphine and lidocaine for 30 min before exposure prevented the reduction in activity induced by 0.1-0.25% acetic acid.These behavioral responses were interpreted as evidence that acetic acid immersion provided a noxious stimulus (i.e. activated nociceptors) that was reliable for use as a model system for the study of analgesic substances. We identify methodological weaknesses and inconsistencies in the interpretation of results, and emphasize that activation of nociceptors was assumed, not demonstrated. As a result of several processes and interactions that were not accounted for or discussed, we warn their conclusions are unfounded.A critical omission was the failure to report water conductivity, hardness and alkalinity data. These determine the magnitude of acute osmoregulatory effects that occur in fish exposed to highly acidic water . Trials by other researchers using water with different conductivity, hardness or alkalinity profiles could, therefore, generate significantly different results. Immersion of fish in low pH water also introduces several unavoidable and uncontrolled interactions that prevent unequivocal interpretation of the behavioral changes observed.For example, sudden exposure of fish to water of pH <4 results in gill dysfunction, iono-regulatory failure and pathological lesions of the gill epithelium . These reduce respiratory efficiency, initiating compensatory behavioral responses such as surface respiration (Kramer, 1987), which appears synonymous with 'top-dwelling behavior' reported by Currie (2014) in adult zebrafish immersed in 0.03% acetic acid ( pH 3.9-4.0). Notably, aquatic surface respiration can occur in a variety of natural circumstances in the absence of nociception (Kramer, 1987), so this behavior is insufficient evidence that nociception is occurring.In contrast to Currie (2014) and Steenbergen and Bardine (2014), Lopez-Luna et al. (2017) considered reduced (not increased) activity as evidence of 'alleged pain behavior' in zebrafish exposed to 0.1-0.25% acetic acid. Steenbergen and Bardine (2014) interpreted increased activity and cyclooxygenase-2 gene expression as evidence of nociception in larval zebrafish immersed in 0.0025-0.025% acetic acid. However, cyclooxygenase-2 expression is a non-specific marker of several physiological processes (Wang et al., 2016), meaning its expression is also insufficient evidence of nociception. A critical observation is that larval zebrafish in the study by Lopez-Luna et al. (2017) continued to exhibit increased a...

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Olfactory toxicity in fishes

Cited by 280 publications

References 154 publications

Multi-biomarker responses as indication of contaminant effects in Gambusia affinis from impacted rivers by municipal effluents

Multi-biomarker responses as indication of contaminant effects in Gambusia affinis from impacted rivers by municipal effluents

Pathology of finfish and mud crabs Scylla serrata during a mortality event associated with a harbour development project in Port Curtis, Australia

Responses of larval zebrafish to low pH immersion assay. Comment on Lopez-Luna et al.

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