Oligomerization state-dependent elevations of adiponectin in chronic daily headache

Peterlin, B. Lee; Alexander, Guillermo M.; Tabby, David; Reichenberger, Erin R.

doi:10.1212/01.wnl.0000312278.40250.6e

Cited by 53 publications

(92 citation statements)

References 38 publications

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“…The required number of participants was inferred by results of studies analyzing adipokines in painful conditions, such as rheumatoid arthritis (16) and headache (17). We concluded that 25 patients would be required in each group to detect a 20% difference in adipokines and cytokines levels.…”

Section: Discussionmentioning

confidence: 99%

Serum levels of leptin and adiponectin and clinical parameters in women with fibromyalgia and overweight/obesity

Paiva

Andretta

Batista

et al. 2017

Arch. Endocrinol. Metab.

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Objectives: The objectives of this study were to evaluate the serum levels of adipokines in women with fibromyalgia with and without overweight/obesity, and to correlate the adipokines levels with clinical parameters associated with fibromyalgia and adipose tissue mass (body fat). Subjects and methods: The study included 100 women divided into four groups: (a) fibromyalgia and overweight/obesity; (b) fibromyalgia and normal weight; (c) controls and overweight/obesity; and (d) controls and normal weight. Patients and controls were evaluated for clinical, anthropometric, and fibromyalgia-related parameters. Assessments included serum levels of leptin, adiponectin, monocyte chemoattractant protein-1 (MCP-1), and C-reactive protein (CRP). Levels of adipokines were further adjusted for fat mass. Results: Fibromyalgia patients with overweight/obesity or normal weight had no differences in clinical parameters. Unadjusted leptin levels were lower in fibromyalgia patients than controls, a finding that was more remarkable in fibromyalgia patients with overweight/obesity. Leptin levels had no correlation with clinical parameters of fibromyalgia or inflammation markers (MCP-1 and CRP), and adiponectin levels showed no difference between groups. Conclusions: No correlation was observed between adjusted leptin levels and clinical parameters of fibromyalgia. Patients with fibromyalgia and overweight/obesity presented lower levels of leptin than controls with overweight/ obesity. Arch Endocrinol Metab. 2017;61(3):249-56.

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Section: Discussionmentioning

confidence: 99%

Serum levels of leptin and adiponectin and clinical parameters in women with fibromyalgia and overweight/obesity

Paiva

Andretta

Batista

et al. 2017

Arch. Endocrinol. Metab.

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“…Its structure is divided into three domains: the N-terminal domain, which has large variation in amino acids between species, the collagen-like domain, and the globular domain of the C-terminal region. 10 The secretion of adiponectin is strictly controlled by the retention of protein thiols, so that two molecular endoplasmic reticulum chaperones play a critical role: 44 kDa ER proteins (endoplasmic reticulum protein 44, ERp44) and Ero1-La (endoplasmic reticulum oxidoreductin 1-like alpha), both induced during adipogenesis. ERp44 forms a disulfide bond with adiponectin, which is important for the maturation of trimeric and hexameric proteins of high-, medium-and low-molecular weight in oligomers.…”

Section: Structure and Secretion Of Adiponectinmentioning

confidence: 99%

Relationship between adiponectin, obesity and insulin resistance

Balsan¹,

Vieira²,

Oliveira³

et al. 2015

Rev. Assoc. Med. Bras.

147

100

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Conflict of interest: noneObjectives: the conditions of obesity and overweight pose a major risk for a number of comorbidities, including clinical syndromes resulting from atherosclerotic disease. Recent studies strongly indicate that adipose tissue is an active endocrine organ that secretes bioactive factors such as adipokines. Adiponectin appears to have a regulatory role in the mechanism of insulin resistance and in the development of atherosclerosis. This systematic review aims to evaluate the anti-atherogenic effects of adiponectin and its properties to improve and mimic metabolic and vascular actions of insulin and its influence on endothelial function. Methods: a qualitative, exploratory and literature review was performed in the PubMed, Portal Capes and Scielo databases using as key-words "adiponectin", "obesity", "insulin resistance", "anti-inflammatory", "therapeutic strategies" and "future prospects". Results: evidence suggests that adiponectin has anti-atherogenic properties with anti-inflammatory effects on the vascular wall. Moreover, it modifies the vascular intracellular signaling and has indirect antioxidant effects on the human myocardium. On the other hand, there are studies suggesting that increased levels of adiponectin are paradoxically associated with a worse prognosis in heart failure syndrome, although the mechanisms are not clear. Conclusion: it is not clear whether adiponectin levels have any clinical significance for risk stratification in cardiovascular disease or if they simply reflect the activation of complex underlying mechanisms. Changes in lifestyle and some drug treatments for hypertension and coronary heart disease have shown significant effect to increase adiponectin levels, and simultaneously decrease in insulin resistance and endothelial dysfunction.

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“…However, adiponectin can exert either pro-or anti-inflammatory properties depending on the form and multimer of adiponectin involved that varies in molecular weights (high (HMW), middle (MMW), or low (LMW) molecular weight) and forms. In a study episodic migraineurs showed a similar trend toward higher levels of total and high molecular weight adiponectin though neither measure reached statistical significance [61]. HMW: LMW ratio of adiponectin was suggested to be potential novel biomarkers for episodic migraine and either antagonist of high molecular weight adiponectin or agonists of low molecular weight adiponectin, or both suggested to be potential targets for headache management.…”

Section: Inflammation-mediated Link Between Obesity and Migrainementioning

confidence: 94%

“…In contrast, LMW adiponectin can inhibit endotoxin-mediated release of IL-6. Adiponectin bears a remarkable similarity to leukocyte activating agent IL-2 and regulates both innate and adaptive immune responses and generally increases levels of pro-inflammatory cytokines and activation of monocytes via the production of cytokines such as TNFα and IL-6 and can induce the expression of nitric oxide and prostaglandin in cultured macrophages [52,[59][60][61][62][63].…”

Section: Inflammation-mediated Link Between Obesity and Migrainementioning

confidence: 99%

Migraine and Obesity: Possible Link to Inflammation

Konukoğlu¹,

Kurtulus²

2016

J Headache Pain Manag

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Oligomerization state-dependent elevations of adiponectin in chronic daily headache

Abstract: Serum adiponectin levels are increased in women chronic daily headache (CDH) sufferers. In addition, visceral obesity, as measured by waist-to-hip ratio, is a risk factor for CDH in women.

Cited by 53 publications

References 38 publications

Serum levels of leptin and adiponectin and clinical parameters in women with fibromyalgia and overweight/obesity

Serum levels of leptin and adiponectin and clinical parameters in women with fibromyalgia and overweight/obesity

Relationship between adiponectin, obesity and insulin resistance

Migraine and Obesity: Possible Link to Inflammation

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