Olive oil and oleic acid-based self nano-emulsifying formulation of omega-3-fatty acids with improved strength, stability, and therapeutics

Tharmatt, Abhay; Thakur, Shubham; Singh, Amrinder; Kaur, Manjot; Shahtaghi, Navid Reza; Malhotra, Divay; Jain, Subheet Kumar

doi:10.1080/02652048.2021.1914760

Cited by 6 publications

(2 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In this regard, nanoformulated vitamin D [352] has been evaluated for treatment of osteoporosis [353] and autoimmune diseases [354] like psoriasis [355], whereas nanoformulations delivering vitamin C [356] and vitamin E [357] in combination with antibodies blocking inhibitory receptors or chemotherapeutics have been tested in tumor therapeutic strategies. A few studies have also shown improved delivery of other dietary supplements like omega-3 fatty acids [358]. Only some studies have included nanoformulations of NAD + precursors to overcome their fast degradation and consequently minor bioavailability of SIRT1.…”

Section: Micronutrientsmentioning

confidence: 99%

Counteracting Immunosenescence—Which Therapeutic Strategies Are Promising?

2023

View full text Add to dashboard Cite

Aging attenuates the overall responsiveness of the immune system to eradicate pathogens. The increased production of pro-inflammatory cytokines by innate immune cells under basal conditions, termed inflammaging, contributes to impaired innate immune responsiveness towards pathogen-mediated stimulation and limits antigen-presenting activity. Adaptive immune responses are attenuated as well due to lowered numbers of naïve lymphocytes and their impaired responsiveness towards antigen-specific stimulation. Additionally, the numbers of immunoregulatory cell types, comprising regulatory T cells and myeloid-derived suppressor cells, that inhibit the activity of innate and adaptive immune cells are elevated. This review aims to summarize our knowledge on the cellular and molecular causes of immunosenescence while also taking into account senescence effects that constitute immune evasion mechanisms in the case of chronic viral infections and cancer. For tumor therapy numerous nanoformulated drugs have been developed to overcome poor solubility of compounds and to enable cell-directed delivery in order to restore immune functions, e.g., by addressing dysregulated signaling pathways. Further, nanovaccines which efficiently address antigen-presenting cells to mount sustained anti-tumor immune responses have been clinically evaluated. Further, senolytics that selectively deplete senescent cells are being tested in a number of clinical trials. Here we discuss the potential use of such drugs to improve anti-aging therapy.

show abstract

Section: Micronutrientsmentioning

confidence: 99%

Counteracting Immunosenescence—Which Therapeutic Strategies Are Promising?

2023

View full text Add to dashboard Cite

show abstract

“…Quercetin-SEFs have a bright yellow color from a combination of oil components, surfactants, and the active compound quercetin. Emulsions are formed after quercetin-SEFs encounter water spontaneously (Tharmatt et al, 2021). The resulting emulsion has a clear to a cloudy character.…”

Section: Quercetin-sefs Formulamentioning

confidence: 99%

Evaluation of Response Corellation Using Chemometrics Analysis for Pre-Optimization Quercetin – Self Emulsion Formulation

Shiyan

Pratiwi³

2022

JFSP

View full text Add to dashboard Cite

The optimization approach using the simplex lattice design (SCD) has many advantages, including a minimized number of experiments and a good description of the interactions between components. However, modeling with the SCD approach has not evaluated between responses. Therefore, this study aims to apply chemometric analysis to evaluate the response from the optimization stage using the quercetin – self emulsion formulations (quercetin-SEFs) as a model. SEFs were prepared using grapeseed oil, croduret, and PEG 400. The evaluated responses included emulsification time and transmittance. Both responses were developed in endurance test by centrifugation method and stability test using freeze-thaw. Chemometric analysis on CA produced a dendrogram, while PCA produced score plots, loading plots, scree plots, and biplots. Emulsification time has a positive correlation with transmittance value. The quercetin-SEFs formula in SCD was classified into three groups based on the similarity of characters. Chemometric analysis was successfully applied in evaluating the response to the quercetin-SEFs optimization modeling.

show abstract