Olive polyphenol effects in a mouse model of chronic ethanol addiction

Carito, Valentina; Ceccanti, Mauro; Cestari, Vincenzo; Natella, Fausta; Bello, Cristiano; Coccurello, Roberto; Mancinelli, Rosanna; Fiore, M.

doi:10.1016/j.nut.2016.08.014

Cited by 45 publications

(39 citation statements)

References 22 publications

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“…No. DY248) were measured using a sandwich enzyme-linked-immunosorbent assay (ELISA) kits (R&D Systems, Minneapolis, MN, USA), according to the protocols provided by the manufacturer and also according to methods previously described [37][38][39]. Serum samples were diluted 2-and 100-fold with PBS for detection of NGF and BDNF, respectively.…”

Section: Ngf and Bdnf Serum Level Evaluationmentioning

confidence: 99%

“…Radicals Test (FORT). FORD and FORT tests were carried out using two specific kits (both purchased by Callegari, Parma, Italy) following the instruction provided by the manufacturer and according to methods previously described [37][38][39]. Blood serum was used both for the FORT and FORD determination.…”

Section: Free Oxygen Radicals Defense (Ford) and Free Oxygenmentioning

confidence: 99%

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Neuroinflammatory Markers in the Serum of Prepubertal Children with Down Syndrome

Tarani

Carito

Ferraguti

et al. 2020

Journal of Immunology Research

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Down Syndrome (DS) is the most common chromosomal disorder. Although DS individuals are mostly perceived as characterized by some distinct physical features, cognitive disabilities, and cardiac defects, they also show important dysregulations of immune functions. While critical information is available for adults with DS, little literature is available on the neuroinflammation in prepubertal DS children. We aimed to evaluate in prepubertal DS children the serum levels of nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF), oxidative stress as free oxygen radicals defense (FORD), free oxygen radicals test (FORT), and cytokines playing key roles in neuroinflammation and oxidative processes as TNF-α, TGF-β, MCP-1, IL-1α, IL-2, IL-6, IL-10, and IL-12. No differences were found in NGF between DS children and controls. However, BDNF was higher in DS subjects compared to controls. We also did not reveal changes in FORD and FORT. Quite interestingly, the serum of DS children disclosed a marked decrease in all analyzed cytokines with evident differences in serum cytokine presence between male and female DS children. In conclusion, the present study evidences in DS prepubertal children a disruption in the neurotrophins and immune system pathways.

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Section: Ngf and Bdnf Serum Level Evaluationmentioning

confidence: 99%

Section: Free Oxygen Radicals Defense (Ford) and Free Oxygenmentioning

confidence: 99%

Neuroinflammatory Markers in the Serum of Prepubertal Children with Down Syndrome

Tarani

Carito

Ferraguti

et al. 2020

Journal of Immunology Research

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“…As for the gestational alcohol consumption, the plethora of effects in children induced by ethanol are described as Fetal Alcohol Spectrum Disorders (120)(121)(122)(123). It has also been clearly demonstrated that chronic or binge alcohol consumption as well as alcohol exposure during development may impair brain neurotrophic factors production and the expression of their receptors (124)(125)(126)(127)(128)(129)(130)(131)(132). NGF is one of the most important neurotrophins involved in ethanol-induced toxicity.…”

Section: Ngf and Alcohol-induced Mental Retardationmentioning

confidence: 99%

Nerve growth factor in brain diseases

et al. 2018

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The nerve growth factor (NGF) belongs to a family of proteins termed neurotrophins, consisting of NGF, brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), NT-4/5 and NT-6. Today, NGF is well recognized to mediate a large number of trophobiological actions resulting in neurotrophic, immunotrophic and/or metabotrophic effects. The pathobiology of neurodegenerative diseases, including Alzheimer disease, psychiatric disorders (e.g. depression and schizophrenia) and brain parasitic infections have in common the effect of altering the brain levels of neurotrophins and in particular NGF. The involvement of NGF and its TrkA receptor in these pathologies and the recent promising results of NGF therapies are presented and discussed.

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“…The risk of FASD depends on the amount of ethanol consumed, the frequency of drinking, and the period of pregnancy during which alcohol is consumed as well as the extremely individual conditions of vulnerability to alcohol . Other risk factors include the age of the mother, smoking habit, and poor diet . Safe amounts of alcohol that might be consumed or a safe time to drink during gestation have not been clearly established at the present time.…”

Section: Introductionmentioning

confidence: 99%

“…Indeed, it has been shown that small amounts of alcohol do not cause gross morphological abnormalities, even though they may induce behavioral and memory impairments and reduced brain volume . Alcohol may easily cross the blood brain barrier and both directly and indirectly may disrupt a developing brain affecting brain cell growth, nervous circuitries, and brain areas physiology by potentiating also oxidative stress . FASD diagnosis is based on several signs and symptoms, and the condition is permanent.…”

Section: Introductionmentioning

confidence: 99%

Fetus morphology changes by second‐trimester ultrasound in pregnant women drinking alcohol

et al. 2019

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Fetal alcohol spectrum disorders (FASDs) are a group of negative conditions occurring in children exposed to alcohol during gestation. The early discovery of FASD is crucial for mother and infant follow-ups. In this study, we investigated in pregnant women the association between urine ethylglucuronide (EtG-a biomarker of alcohol drinking) and indicators of the physical characteristics of FASD by prenatal ultrasound in the second trimester of gestation. We also correlated these data with the AUDIT-C, T-ACE/TACER-3, TWEAK, and food habit diary, screening questionnaires used to disclose alcohol drinking during pregnancy. Forty-four pregnant women were randomly enrolled and examined for ultrasound investigation during the second trimester of gestation. Urine samples were provided by pregnant women immediately after the routine interviews. EtG determinations were performed with a cutoff established at 100 ng/mL, a value indicating occasional alcohol drinking. Fifteen of the enrolled pregnant women overcame the EtG cutoff (34.09%). Analysis of variance (ANOVA) revealed that the fetuses of the positive EtG pregnant women had significantly longer interorbital distance and also significantly increased frontothalamic distance (P's < 0.02). Quite interestingly, no direct correlation was found between EtG data and both food diary and AUDIT-C. However, a significant correlation was observed between urinary EtG and T-ACE (r = 0.375; P = 0.012) and between urinary EtG and TWEAK (r = 0.512; P < 0.001) and a concordance with all questionnaire for EtG values higher than 500 ng/mL. This study provides clinical evidence that the diagnosis of maternal alcohol consumption during pregnancy by urine EtG may disclose FASD-related damage in the fetus.

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Olive polyphenol effects in a mouse model of chronic ethanol addiction

Abstract: A better understanding of the antioxidant protection provided by polyphenols might be of primary interest for drug discovery and dietary-based prevention of the damage associated with chronic alcohol abuse.

Cited by 45 publications

References 22 publications

Neuroinflammatory Markers in the Serum of Prepubertal Children with Down Syndrome

Neuroinflammatory Markers in the Serum of Prepubertal Children with Down Syndrome

Nerve growth factor in brain diseases

Fetus morphology changes by second‐trimester ultrasound in pregnant women drinking alcohol

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