Olive tree leaves as a great source of phenolic compounds: Comprehensive profiling of NaDES extracts

Mir-Cerdà, Aina; Granados, Mercè; Saurina, Javier; Sentellas, Sonia

doi:10.1016/j.foodchem.2024.140042

Food Chemistry

2024

DOI: 10.1016/j.foodchem.2024.140042

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Olive tree leaves as a great source of phenolic compounds: Comprehensive profiling of NaDES extracts

Aina Mir-Cerdà,

Mercè Granados,

Javier Saurina

et al.

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2024

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Cited by 3 publications

References 54 publications

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Towards a sustainable recovery of polyphenols from agrifood waste: Performance of polymeric sorbents with natural deep eutectic solvent extracts

Mir-Cerdà,

Ramos-Calero,

Beltrán

et al. 2024

LWT

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Towards a sustainable recovery of polyphenols from agrifood waste: Performance of polymeric sorbents with natural deep eutectic solvent extracts

Mir-Cerdà,

Ramos-Calero,

Beltrán

et al. 2024

LWT

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Therapeutic Potential of Olive Leaf Extracts: A Comprehensive Review

de Oliveira,

Machado,

Chéu

et al. 2024

Applied Biosciences

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The olive tree is currently cultivated worldwide, with higher incidence in Mediterranean Basin. Its climate is highly favorable to the synthesis of phenolic compounds, stored in olive leaves; their consumption has been linked to a lower incidence of cancer and cardiovascular disorders for which the research interest upon this feature has increased in last decade. This study aimed (i) to review evidence about the importance of olive leaf extract (OLE) on human health and the physiological effect of its major compounds; (ii) to update the state of the art of studies conducted on the health and technological usage of olive leaf extract; (iii) to report potential uses of OLE in pharmaceuticals, food production, and cosmetics; and (iv) to prospect the future of clinical applications of OLE from diverse cultivars, especially in metabolic inflammatory conditions such as polycystic ovary syndrome (PCOS). Overall, cultivars richer in TPC, including TFC, αT, omega-3 and omega-9, present a main research target for supplementation alone or in conjunction with vitaminic compounds, due to their nutraceutical value in metabolic disorders, chronic inflammatory diseases, and anti-aging treatments, whereas cultivars with less water content might be useful as substrates for food preservation. With regard to future prospects, it would be of great interest to clarify the specific mechanisms underlying the beneficial effects of OLE on neuro-immune and cardiovascular health to design safer and healthier nature-based medicine for a wide array of costly and highly prevalent chronic diseases, such as inflammatory and metabolic-related syndromes, namely, PCOS.

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Anti-Inflammatory and Neuroprotective Polyphenols Derived from the European Olive Tree, Olea europaea L., in Long COVID and Other Conditions Involving Cognitive Impairment

Papadopoulou,

Polissidis,

Kythreoti

et al. 2024

IJMS

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The European olive tree, Olea europaea L., and its polyphenols hold great therapeutic potential to treat neuroinflammation and cognitive impairment. This review examines the evidence for the anti-inflammatory and neuroprotective actions of olive polyphenols and their potential in the treatment of long COVID and neurodegenerative diseases such as Alzheimer’s disease (AD), Parkinson’s disease (PD), and multiple sclerosis (MS). Key findings suggest that olive polyphenols exhibit antioxidant, anti-inflammatory, neuroprotective, and antiviral properties, making them promising candidates for therapeutic intervention, especially when formulated in unique combinations. Recommendations for future research directions include elucidating molecular pathways through mechanistic studies, exploring the therapeutic implications of olive polyphenol supplementation, and conducting clinical trials to assess efficacy and safety. Investigating potential synergistic effects with other agents addressing different targets is suggested for further exploration. The evidence reviewed strengthens the translational value of olive polyphenols in conditions involving cognitive dysfunction and emphasizes the novelty of new formulations.

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Olive tree leaves as a great source of phenolic compounds: Comprehensive profiling of NaDES extracts

Cited by 3 publications

References 54 publications

Towards a sustainable recovery of polyphenols from agrifood waste: Performance of polymeric sorbents with natural deep eutectic solvent extracts

Towards a sustainable recovery of polyphenols from agrifood waste: Performance of polymeric sorbents with natural deep eutectic solvent extracts

Therapeutic Potential of Olive Leaf Extracts: A Comprehensive Review

Anti-Inflammatory and Neuroprotective Polyphenols Derived from the European Olive Tree, Olea europaea L., in Long COVID and Other Conditions Involving Cognitive Impairment

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