Olive tree wood phenolic compounds with human platelet antiaggregant properties

Zbidi, Hanene; Salido, Sofı́a; Altarejos, Joaquı́n; Pérez-Bonilla, Mercedes; Bartegi, Aghleb; Rosado, Juan A.; Salido, Ginés M.

doi:10.1016/j.bcmd.2009.01.001

Cited by 54 publications

(43 citation statements)

References 48 publications

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“…Other than being an effective radical scavenger, (+)-cycloolivil possesses antiplatelet aggregation properties and inhibits protein tyrosine phosphorylation, suggesting that it may prevent diseases associated with platelet hyper-aggregability. [42] Its presence in most toasted woods, together with verbascoside, olivil and syringaresinol, all biologically active compounds, [39] could contribute to producing healthier wines when using seasoned or toasted ash wood in the wine aging.…”

Section: Dilignols and Oligolignolsmentioning

confidence: 99%

LC‐DAD/ESI‐MS/MS study of phenolic compounds in ash (Fraxinus excelsior L. and F. americana L.) heartwood. Effect of toasting intensity at cooperage

Sanz¹,

Simón

Cadahía

et al. 2012

J. Mass. Spectrom.

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The phenolic composition of heartwood extracts from Fraxinus excelsior L. and F. americana L., both before and after toasting in cooperage, was studied using LC-DAD/ESI-MS/MS. Low-molecular weight (LMW) phenolic compounds, secoiridoids, phenylethanoid glycosides, dilignols and oligolignols compounds were detected, and 48 were identified, or tentatively characterized, on the basis of their retention time, UV/Vis and MS spectra, and MS fragmentation patterns. Some LMW phenolic compounds like protocatechuic acid and aldehyde, hydroxytyrosol and tyrosol, were unlike to those for oak wood, while ellagic and gallic acid were not found. The toasting of wood resulted in a progressive increase in lignin degradation products with regard to toasting intensity. The levels of some of these compounds in medium-toasted ash woods were much higher than those normally detected in toasted oak, highlighting vanillin levels, thus a more pronounced vanilla character can be expected when using toasted ash wood in the aging wines. Moreover, in seasoned wood, we found a great variety of phenolic compounds which had not been found in oak wood, especially oleuropein, ligstroside and olivil, along with verbascoside and isoverbascoside in F. excelsior, and oleoside in F. americana. Toasting mainly provoked their degradation, thus in medium-toasted wood, only four of them were detected. This resulted in a minor differentiation between toasted ash and oak woods. The absence of tannins in ash wood, which are very important in oak wood, is another peculiar characteristic that should be taken into account when considering its use in cooperage.

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Section: Dilignols and Oligolignolsmentioning

confidence: 99%

LC‐DAD/ESI‐MS/MS study of phenolic compounds in ash (Fraxinus excelsior L. and F. americana L.) heartwood. Effect of toasting intensity at cooperage

Sanz¹,

Simón

Cadahía

et al. 2012

J. Mass. Spectrom.

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“…70 Yine yapılan bir başka çalışmada sikloolivil ve oleuropeinin platelet agregasyonunu azalttığı bildirilmiştir. 71 …”

Section: Zeyti̇n Yaprağinin Anti̇tromboti̇k Etki̇si̇unclassified

Potential Health Benefits of Olive Leaf

Gülbaran¹,

Öğüt²

2018

Turkiye Klinikleri J Health Sci

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“…Platelet aggregation was monitored in 400 μl samples of washed platelets using a Chronolog aggregometer (Havertown, Pa, USA), as described elsewhere [12,82]. Platelets were kept during the experiments at 37°C and stirring at 1200 rpm, and they were stimulated as follows: Human platelets suspended in HBS medium were supplemented with 1 mM CaCl 2 , and after incubation for 1 min, aggregation was stimulated by adding 0.1 U/ml of Thr.…”

Section: Platelet Aggregation Assaysmentioning

confidence: 99%

“…In particular, certain platelet signaling pathways relay on the second messengers of lipid nature that are very sensitive to oxidation by ROS, like arachidonic acid (AA) [73]. Hence, during the last decade, the use of antioxidants has been widely recommended to palliate diseases associated to oxidative stress, including those associated to platelet hyperactivity [7,41,82].…”

Section: Introductionmentioning

confidence: 99%

“…Considering that ROS are in the background of many diseases, from cardiovascular to cancer, to provide new antioxidant formulations that might prevent the appearance of these diseases linked with a ROS overproduction would be a step forward in the management of these diseases. And, keeping in mind the results recently published by us about the inhibitory effect of some phenolic compounds on platelet aggregation [12,82], three ascorbyl phenolic esters related to Asc were designed and synthesized. Evaluation of the antiaggregant and antioxidant activity was also investigated.…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of the antiaggregant activity of ascorbyl phenolic esters with antioxidant properties

et al. 2015

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Beneficial effects of the antioxidant L-ascorbic acid (Asc) in human health are well known. Its particular role in hemostasis deserves further consideration, since it has been described a dose-dependent effect of Asc in platelet activity. Contrary, it has been demonstrated that phenolic compounds have inhibitory effects on platelet aggregation stimulated by the physiological agonist thrombin (Thr). Here, we have evaluated the actions of three synthetic phenolic esters of Asc: L-ascorbyl 6-protocatechuate (Prot Asc), L-ascorbyl 6-gallate (Gal Asc), and L-ascorbyl 6-caffeate (Caf Asc). All these Asc derivatives exhibited greater radical scavenging activity than Asc, and in experiments using human platelets from healthy subjects, they do not evoke changes in platelet viability upon their administration. Nevertheless, these compounds altered platelet calcium homeostasis in response to Thr, although Prot Asc induced a smaller effect than Gal Asc, Caf Asc, and Asc. As a consequence, platelet aggregation was also impaired by these compounds, reporting Prot Asc and Caf Asc a weaker antiaggregant action than Gal Asc and Asc. Treatments with Gal Asc and Caf Asc altered in larger extent the phosphorylation pattern of pp60(Src) and mammalian target of rapamycin (mTOR) evoked by stimulating human platelets with Thr. Summarizing, Prot Asc is the ascorbyl phenolic ester with the strongest antioxidant properties and weakest antiaggregant actions, and its use as antioxidant may be safer than the rest of derivatives in order to prevent thrombotic alteration in patients that need treatment with antioxidant therapies.

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Olive tree wood phenolic compounds with human platelet antiaggregant properties

Cited by 54 publications

References 48 publications

LC‐DAD/ESI‐MS/MS study of phenolic compounds in ash (Fraxinus excelsior L. and F. americana L.) heartwood. Effect of toasting intensity at cooperage

LC‐DAD/ESI‐MS/MS study of phenolic compounds in ash (Fraxinus excelsior L. and F. americana L.) heartwood. Effect of toasting intensity at cooperage

Potential Health Benefits of Olive Leaf

Evaluation of the antiaggregant activity of ascorbyl phenolic esters with antioxidant properties

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