Omalizumab is Effective and Safe in the Treatment of Japanese Cedar Pollen-induced Seasonal Allergic Rhinitis

Okubo, Kimihiro; Ogino, Satoshi; Nagakura, Toshikazu; Ishikawa, Takeru

doi:10.2332/allergolint.55.379

Cited by 93 publications

(65 citation statements)

References 21 publications

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“…Therefore, we concluded that the plant sequences with homology to conifers were probably derived from chloroplasts in airborne pollen grains. Seasonal allergic rhinitis (SAR) to Japanese cedar pollen is a major public health problem in Japan (Okubo et al 2006). Pinus pollen allergy has also been reported (Marcos et al 2001).…”

Section: Discussionmentioning

confidence: 99%

Seasonal variations in airborne bacterial community structures at a suburban site of central Japan over a 1-year time period using PCR-DGGE method

et al. 2014

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Airborne bacteria could affect human health and climate. In this study, the bacterial community structures were investigated by analyzing air samples collected from a suburban location in Toyama, central Japan. Sixty samples were collected almost weekly between March 2009 and February 2010. A cultivation-independent approach, PCR plus denaturing gradient gel electrophoresis (DGGE), was used to analyze changes in the structure of the airborne bacterial communities. The DGGE profiles showed significant differences between sampling days, reflecting quite different bacterial profiles. Sequencing of DGGE bands revealed that the bacterial community was dominated by c-Proteobacteria, Firmicutes, aProteobacteria, Bacteroidetes, and Actinobacteria. The most frequently observed genus was Pseudomonas, followed by Bacillus. The airborne bacterial assemblage in winter differed from that in the other seasons. The differences could be attributed a number of factors, such as temperature, relative humidity, wind direction, and snowfall. In spring, the largest number of bands was classified as plant chloroplasts, such as Japanese cedar (Cryptomeria japonica) and Pinus spp., which are the major pollen allergen sources in Japan. The airborne bacterial abundance estimated by real-time TaqMan PCR ranged from 1.1 9 10 3 to 1.3 9 10 5 cells m -3 .

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Section: Discussionmentioning

confidence: 99%

Seasonal variations in airborne bacterial community structures at a suburban site of central Japan over a 1-year time period using PCR-DGGE method

et al. 2014

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“…Among these, omalizumab, a humanized monoclonal antibody that binds circulating IgE and prevents its attachment to high-affinity IgE receptors, is the most extensively studied agent approved for the treatment of severe uncontrolled asthma with perennial sensitizations. However, a growing number of reports indicate its effectiveness in seasonal and perennial AR in adults/adolescents [90][91][92][93][94] and children [95][96][97][98][99]. Targeting the early phase of the allergic cascade could prove a significant allergic march-preventing treatment.…”

Section: Other Interventionsmentioning

confidence: 99%

Pediatric Allergic Rhinitis and Asthma: Can the March be Halted?

et al. 2013

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The strong epidemiologic and pathophysiologic link between allergic rhinitis (AR) and asthma has led to the concept of 'united airways disease' or 'respiratory allergy', implying that allergy, in its widest sense, underlies this clinical syndrome. Progression from AR to asthma is frequent and part of the 'atopic march'. Since pediatric immune responses are more adaptable and therefore may be more amenable to treatment, interventions at early childhood are characterized by a higher chance to affect the natural history of respiratory allergy. Although current treatments are quite effective in alleviating respiratory allergy symptoms, it has proven much more difficult to confirm any influence on the progression of the disease. Much more promising is the field of specific allergen immunotherapy, where current evidence, although not yet of ideal robustness, points towards a disease-modifying effect. In addition, newer or emerging, possibly more effective or more targeted interventions are promising in the preventive sense.

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“…Okubo y cols 19,20 realizaron un estudio ramdomizado, doble ciego controlado con placebo, en 100 pacientes japoneses con historia de RAE moderada-severa a polen de cedro japonés, en dos regiones de Japón (Tokyo y Osaka), entre octubre de 2001 y abril de 2002. Se administró Omalizumab a dosis de 150, 225, 300 ó 375 mg o placebo en forma SC cada 2 o 4 semanas de acuerdo a los niveles basales de IgE total y peso corporal.…”

Section: Estudios En Rinitis Alérgica Estacional (Ras)unclassified

Anticuerpo monoclonal anti-inmunoglobulina E en el tratamiento de la rinitis alérgica

2011

Rev. Otorrinolaringol. Cir. Cabeza Cuello

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RESUMENLa rinitis alérgica (RA) es una enfermedad con alta incidencia a nivel mundial, sus síntomas están directamente relacionados con la exposición a un alérgeno ambiental que desencadena una cascada inflamatoria mediada por inmunoglobulina E. El tratamiento convencional actual de la RA consta del control ambiental, farmacoterapia e inmunoterapia; la reciente aparición de los anticuerpos monoclonales para el manejo de las enfermedades alérgicas parece ser prometedora. Estudios han demostrado que el Omalizumab, un anticuerpo monoclonal humanizado anti IgE, es capaz de modificar la respuesta inflamatoria dependiente de IgE, constituyéndose en una posible alternativa al manejo de la RA.Palabras claves: Rinitis alérgica, anticuerpo monoclonal Anti-IgE, Omalizumab. ABSTRACTAllergic rhinitis (AR) is a disease with global high prevalence, its symptoms are directly related to environmental exposure to an allergen that triggers an inflammatory cascade mediated by Immunoglobulin E. The current standard treatment of AR consists of environmental control, pharmacotherapy and immunotherapy; the recent emergence of Monoclonal Antibodies for the management of allergic diseases appears promising. Studies have shown that Omalizumab, an anti-IgE humanized monoclonal antibody, is capable of modify the inflammatory IgE-dependent response, becoming a possible alternative to the management of AR.

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Omalizumab is Effective and Safe in the Treatment of Japanese Cedar Pollen-induced Seasonal Allergic Rhinitis

Abstract: Omalizumab was effective and safe in the treatment of SAR induced by Japanese cedar pollen.

Cited by 93 publications

References 21 publications

Seasonal variations in airborne bacterial community structures at a suburban site of central Japan over a 1-year time period using PCR-DGGE method

Seasonal variations in airborne bacterial community structures at a suburban site of central Japan over a 1-year time period using PCR-DGGE method

Pediatric Allergic Rhinitis and Asthma: Can the March be Halted?

Anticuerpo monoclonal anti-inmunoglobulina E en el tratamiento de la rinitis alérgica

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